Chemical constituents of Allophylus africanus

Oladosu, I. A.; Balogun, Sikiru Olaitan; Liu, Zhiqiang

doi:10.1016/s1875-5364(15)60017-6

Cited by 15 publications

(13 citation statements)

References 12 publications

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“…Except for pinitol which didn't show any antimicrobial activity, none of identified compounds in this plant were tested for this activity (Manríquez-Torres et al 2007;Oladosu et al 2015).…”

Section: Allophylus Africanus P Beauv (Sapindaceae)mentioning

confidence: 99%

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

2015

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In a world of increasing resistance to current antibiotics, search of novel therapeutic options is urgently needed. The aim of this work was to screen plant crude extracts for direct or indirect (inhibition of resistance) antimicrobial activity. Four crude extracts from 12 plants traditionally used in Africa for the treatment of infections were obtained by successive extraction with hexane, dichloromethane, ethyl acetate, and methanol. All extracts were tested against Staphylococcus aureus MRSA ATCC33591 [resistant to b-lactams by production of b-lactamases and of a modified PBP target (PBP2a)]. Direct antimicrobial activity was tested by determination of Minimal Inhibitory Concentrations (MIC), and indirect activity, by determining interactions between antibiotics and extracts using checkerboard titration and calculation of Fractional Inhibitory Concentration Index (FICI; synergy: FICI B 0.5; additivity: FICI B 1). Combined antibiotics were ampicillin (sensitive to resistance mediated by b-lactamases and PBP2a) and oxacillin (sensitive to resistance mediated by PBP2a only). The dichloromethane extract of Vitellaria paradoxa leaves, the methanol extracts of Vitellaria paradoxa, Cola gigantea leaves and twigs, and of Tapinanthus bangwensis aerial parts showed direct antimicrobial activity (MIC 250-500 mg/L). The methanol extracts of Vitellaria paradoxa and Cola gigantea leaves and twigs showed additive or synergistic effects with oxacillin and ampicillin on MRSA ATCC33591 (FICI 0.28-1), suggesting a possible inhibition of PBP2a. The methanol extract of Tapinanthus bangwensis aerial parts and Anchomanes difformis roots improved the activity of ampicillin only (FICI 0.38-1), suggesting b-lactamase inhibition. Polyphenols and particularly tannins were shown to be responsible for these last effects, at least partially for Vitellaria paradoxa. These data need further research aiming at identifying the active compounds in these extracts.

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“…Except for pinitol which didn't show any antimicrobial activity, none of identified compounds in this plant were tested for this activity (Manríquez-Torres et al 2007;Oladosu et al 2015).…”

Section: Allophylus Africanus P Beauv (Sapindaceae)mentioning

confidence: 99%

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

2015

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“…One of the strategies used to overcome resistance mechanisms in combination therapy includes combined active drug or polyherbal formulations [ 10 ]. The use of natural products in combination with antibiotics to enhance treatment efficacy is a new strategy developed to overcome the problem of antibiotics resistance [ 104 ].…”

Section: Mechanisms Of Action Of Medicinal Plantsmentioning

confidence: 99%

“…Research efforts are expediting for better functional understanding of medicinal plants, and this has provided a model for about 25–50% of the marketed drugs [ 9 ]. Antimicrobial activities of useful plants vary; the majority act in synergy [ 10 ], reducing the side effect of synthetic drugs [ 11 ], while others act as quorum quenchers [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Importance of Medicinal Plants in Nigeria

Ugboko

Nwinyi

Oranusi

et al. 2020

The Scientific World Journal

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Despite the success of antibiotic discovery, infectious diseases remain the second leading source of death worldwide, while the resistance to antibiotics is among the significant problems in the twenty-first century. Medicinal plants are very rich in phytochemicals which can be structurally optimized and processed into new drugs. Nigeria enjoys a diverse collection of medicinal plants, and joint research has ascertained the efficacy of these plants. Plants such as guava (Psidium guajava), ginger (Zingiber officinale), neem (Azadirachta indica), and moringa (Moringa oleifera) have been found to exhibit broad range of antimicrobial activities. Studies on Nigerian plants have shown that they contain alkaloids, polyphenols, terpenes, glycosides, and others with possible therapeutic potentials. The antimicrobial activities of some new compounds such as alloeudesmenol, hanocokinoside, orosunol, and 8-demethylorosunol, identified from medicinal plants in Nigeria, are not yet explored. Further investigation and optimization of these compounds will facilitate the development of new sets of pharmacologically acceptable antimicrobial agents. This review study revealed the efficacy of medicinal plants as an alternative therapy in combating and curtailing the development and survival of multidrug-resistant pathogens coupled with the toxic effects of some antibiotics. Due to enormous therapeutic possibilities buried in medicinal plants, there is a need for more research into unique fingerprints and novel compounds that can provide cure to the neglected tropical diseases (NTDs) of humans and animals facing Africa, especially Nigeria.

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“…It has been reported that 32 compounds representing 88% of the essential oil from leaves of A. africanus were characterized and 35 compounds from oil of flowers of A. africanus were identified [10]. In addition, isolation and identification of four new compounds, allotaraxerolide, alloeudesmenol, hanocokinoside and alloaminoacetaldehyde together with 2 compounds known, pinitol and stigmastane-3β, 4β-diol were reported in the whole plant of A. africanus [11]. Reported isolated compounds from whole plant of A. africanus are allotaraxerolide, hanocokinoside, alloeudesmenol, alloaminoacetaldehyde, stigmastane-3β, 4β-diol and pinitol.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Secondary Metabolite from the Stem Bark Extract of Allophylus africanus Beauv (Sapindaceae)

Kwekowe¹,

Johnbull²,

Otuokere³

2021

JCSN

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Isolation of secondary metabolites from the stem bark of Allophylus africanus Beauv (Sapindaceae) was carried out. The plant has a wide distribution in West Africa, with Nigeria (Mambila Plateau, Calabar) inclusive. It has been used in communities for both its medicinal and economic importance. The stem bark of A. africanus was extracted by percolation using chloroform as solvent and concentrated by evaporation at room temperature. Single spot with an Rf value of 0.87 was obtained at a solvent mixture of hexane: chloroform at ratio 2:8 from finger column chromatography . Characterization using spectra analysis which include FT-IR, 1H-NMR, 13C-NMR, H-H COSY, H-C COSY, 135 DEPT and mass spectroscopy. Spectroscopic studies of A. Africanus stem bark extract led to the elucidation of the structure of the compound. FT-IR spectrum indicates that the compound is an aromatic derivative. Aromatic protons where seen at the 1H-NMR chemical shift values of 7.25 ppm. Olefinic protons at 5.124, 5.146 and 6.162 ppm appeared as doublets of doublets of doublets. The compound 1-((E)- 7(((1E,5E)-6-((2,3-dimethyl-4-(((E)-3,4,5,6-tetramethyldeca-7,9-dien-2-yl)oxy)pentyl)oxy)-3,4- dimethylhexa-1,5-dien-1-yl)oxy)hept-4-en-1-yl)-4-propylbenzene was isolated.

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Chemical constituents of Allophylus africanus

Cited by 15 publications

References 12 publications

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

Antimicrobial Importance of Medicinal Plants in Nigeria

Isolation and Characterization of Secondary Metabolite from the Stem Bark Extract of Allophylus africanus Beauv (Sapindaceae)

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