Chemical Constituents of Dichrocephala integrifolia

Abstract

Dichrocephala integrifolia (Asteraceae) is a small herb widely distributed in many countries in Asia, Africa, and the Middle East. Many species of the genus Dichrocephala are used as folk medicines for ulcer, fever, hypertension, and pneumonia. In addition, the leaves of D. integrifolia are used for treating malaria and hepatitis. The composition of the essential oil from the leaves and flowers of D. integrifolia has been reported [1,2]. There are also some studies on the aerial parts of D. integrifolia, and some of its compounds show inhibitory effects on NO production and induced NO synthase inhibitory activities [3].In our continuing studies on bioactive compounds from plants [5-9], we investigated the aerial parts of Dichrocephala integrifolia. A review of the literature shows that several chemical compounds have been isolated from this plant, including diterpene lactones, sesquiterpene lactones, sterols, dicaffeoylquinic acid, and flavonoids [3,4]. In continuation of our investigation on this plant, eight compounds were isolated and elucidated here.The dried and chopped aerial parts of Dichrocephala integrifolia (6 kg) were extracted three times with EtOH (24 L) and successively fractionated into petroleum ether, CH 2 Cl 2 , EtOAc, and n-BuOH fractions. The four fractions were subjected to all kinds of column chromatography and Prep-TLC to obtain eight compounds characterized as 3-O-methyleupatorin (1), quercetin-3-O-glucoside (2), N-benzoylphenylalaninyl-N-benzoylphenylalaninate (3), aurantiamide acetate (4), 2-hydroxyolean-12-ene-23,28-dioic acid-3-O--D-glucopyranoside (5), 3,4-dicaffeoylquinic acid (6), dichrocephol B (7), and dichrocephol C (8) by analyzing their spectral data and by comparing with published data in the literature.Compound 1, yellow needle crystals (acetone), characterized as 3-O-methyleupatorin [10].

Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

“…Dichrocephala integrifolia is a plant belonging to the family Asteraceae, and that is widely distributed in Africa, Asia, Turkey-Europe, and the Middle East [ 26 ]. The various uses of this plant in traditional medicine have been commonly reported in many countries.…”

“…In Cameroon, this plant locally known as “mbag,” “api,” “ngninada elokn,” “kévé,” and “ganki” is used as a therapy for fever, diarrhea, hypertension, malaria, asthma, inflammatory diseases, stomach ulcers, memory impairment and liver dysfunctions [ 32 – 36 ]. The chemical constituents of D. integrifolia includes: diterpene lactones, sesquiterpenes lactones, sterols, dichrocephol, dicaffeoylquinic, saponins, alkaloids anthraquinones, and flavonoids [ 26 , 37 ]. A study conducted by Ngueguim and collaborators in 2016, showed that D. integrifolia leaves' aqueous extract prevents liver damage induced by chronic ethanol administration in rats [ 33 ].…”

“…e chemical constituents of D. integrifolia includes: diterpene lactones, sesquiterpenes lactones, sterols, dichrocephol, dicaffeoylquinic, saponins, alkaloids anthraquinones, and flavonoids [26,37]. A study conducted by Ngueguim and collaborators in 2016, showed that D. integrifolia leaves' aqueous extract prevents liver damage induced by chronic ethanol administration in rats [33].…”