Chemical constituents of Eremomastax speciosa (Hochst.) Cufod leaves and its cytotoxic potential on NIH-3T3 cells

Eve, M. O.; Alfred, Travis; Akripo, I. I.; Ubana, E. E.

doi:10.4314/bcse.v34i3.18

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Many fatty acids were identified in the topical cream. GC-MS is suitable for the identification of volatile and fatty components of natural extracts and plant samples including fatty acids (Eve et al, 2020;Carol et al, 2017;Koudoro et al, 2022). It could be suggested that most of the fatty acids are coming from the beeswax and shea butter which were used as important matrix components for the production of the cream.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Evaluation of Anti-tyrosinase and Anti-Oxidative Effects of Topical Cream Formulation from Acacia sieberiana, Vitellaria paradoxa and Beeswax

et al. 2023

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Skin diseases can get natural therapies from medicinal plant-based products. In this study, a topical cream was formulated from ethanol extract of Acacia sieberiana, beeswax and Vitellaria paradoxa (shea) butter. GC-MS characterization with co-injection of the topical cream revealed Stearic acid (31.43%), Palmitic acid (23.15%), Oleic acid (21.44%) and Linoleic acid (16.20%) as the major components. Seven phenolic conpounds were identified and quantified by HPLC- DAD and Ferulic acid (12.81±0.26 mg/g) was the most abundant. The cream showed good antioxidant properties evaluated through ?-Carotene-linoleic acid assay, DPPH• radical scavenging, ABTS•+ assay, CUPRAC assay, and metal chelating assay. The cream had higher activity in the DPPH• assay (IC50 = 32.10±0.84 µg/mL), ABTS•+ assay (IC50 = 22.49±0.62 µg/mL) and CUPRAC assay (IC50 = 49.27±0.79 µg/mL) than ?-Tocopherol. The antioxidant effects are an indication that the cream can reduce oxidative stress on the skin including aging, carcinogenesis and inflammation. At 100 µg/mL, the topical cream showed tyrosinase inhibition of 48.23±0.87% regarded as relatively good compared to the standard tyrosinase inhibitor kojic acid, which showed 79.50±0.32% inhibition at the same concentration. The cosmetic cream was able to inhibit the melanin production rate-limiting enzyme, tyrosinase, indicating that it can control hyperpigmentation and skin spots.

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Section: Discussionmentioning

confidence: 99%

Chemical Composition and Evaluation of Anti-tyrosinase and Anti-Oxidative Effects of Topical Cream Formulation from Acacia sieberiana, Vitellaria paradoxa and Beeswax

et al. 2023

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Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin

Alain¹,

Tamfu²,

Küçükaydın³

et al. 2022

LWT

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A new abietane-type diterpenoid from roots of Burkea africana Hook (Fabaceae) with α-amylase inhibitory potential

Feunaing

Tamfu

Ntchapda

et al. 2021

Natural Product Research

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A new abietane-type diterpenoid, rubesanolidic acid (1), alongside six known compounds including β-sitosterol (2), lupeol (3), betulenic acid (4) ursolic acid (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and stigmasterol 3-O-β-D-glucopyranoside (7) were isolated from the roots of Burkea africana through column chromatography. Their structures were elucidated from spectroscopic analyses (UV, IR, MS, 1D and 2D NMR) data and by comparison with data from previous studies. The extract and compounds were tested for their α-amylase inhibition. The extract was more active than the isolated compounds with a percentage inhibition of 51.0±2.5 % at 400 µg/mL and was the only sample showing above 50% inhibition at this dose. Amongst the isolated compounds and at the dose of 400 µg/mL, the new diterpenoid Rubesanolidic acid exibited the highest percentage inhibition of α-amylase of 38.2±2.0% while β-sitosterol showed the lowest inhibition of 9.6±0.5%. The results indicate that B. africana is a potential source of antidiabetic compounds.

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Chemical constituents of Eremomastax speciosa (Hochst.) Cufod leaves and its cytotoxic potential on NIH-3T3 cells

Cited by 4 publications

References 16 publications

Chemical Composition and Evaluation of Anti-tyrosinase and Anti-Oxidative Effects of Topical Cream Formulation from Acacia sieberiana, Vitellaria paradoxa and Beeswax

Chemical Composition and Evaluation of Anti-tyrosinase and Anti-Oxidative Effects of Topical Cream Formulation from Acacia sieberiana, Vitellaria paradoxa and Beeswax

Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin

A new abietane-type diterpenoid from roots of Burkea africana Hook (Fabaceae) with α-amylase inhibitory potential

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