Chemical Constituents of Essential Oil from &lt;i&gt;Anethum sowa&lt;/i&gt; L. Herb (Leaf and Stem) Growing in Bangladesh

Saleh-e-In, Moshfekus; Sultana, Abida; Husain, M. M.; Roy, Sudhangshu Kumar

doi:10.3329/bjsir.v45i2.5721

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…It was reported that apiol (20%) was found as the main compound in the root essential oil of Anethum graveolens L. [ 7 ]. In the earlier studies, phenylpropanoid compounds were the rich level in leaf and stem part of A. sowa L. [ 51 , 52 ]. On the other hand, apiol was also found in some umbelliferae plants like parsley ( Petroselinum sativum and Petroselinum crispum ) which have accounted for 18.23 and 17.54% respectively [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and pharmacological significance of Anethum Sowa L. Root

Saleh-e-In

Sultana

Rahim

et al. 2017

BMC Complement Altern Med

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BackgroundMedicinal herbs are used for the treatment of different ailments since antiquity. Different parts of Anethum sowa L. is used in folk medicine as a carminative for the treatment of flatulence, colic and hiccups of infants and children, antioxidant, antimicrobial and antispasmodic agent. The aim of our present study is to evaluate the chemical composition of the essential oil, proximate and elemental composition, amino acid, fatty acid profile and thermal behaviour of its root part as well as different pharmacological activities like antioxidant, antimicrobial and cytotoxicity of the root essential oil.MethodsThe air-dried roots of Anethum sowa L. were subjected to hydro-distillation to yield the essential oil. The antioxidant activity of the essential oil was studied by DPPH radical scavenging activity. The antimicrobial activity was tested against four Gram-positive, six Gram-negative bacteria and four fungi species. The minimum inhibitory concentration (MIC) and Minimum bacterial concentration (MBC) for each examined microorganism were determined using the micro-dilution method. The LC50 value of the oil was also evaluated by brine shrimp lethality assay. The subsequent proximate analysis was also done by AOAC methods. The elemental analysis of the root powder was analysed by ICP-MS, AAS and FP system. The fatty acid was extracted by hot and cold extraction method and the analyses were carried out by GC. The amino acid profile was done by the amino acid analyzer. The DTA, DTG and TG of the root powder were taken by the thermogravimetric analyzer.ResultsA total of 24 constituents was identified and quantified in the essential oil and its water extract portion by GC and GC-MS. Apiol (81.99 and 74.779%) was found the highest phenylpropanoid constituent followed by m-diaminobenzene (10.446 and 8.778%) in the essential oil and aqueous extract portion. On the other hand, β-butyrolactone (5.13%) and isobutyl acetone (3.73%) were found in the major constituents in the water extract part. The IC50 value of the essential oil was found to be 3.07 mg/mL by DPPH radical assay methods. The LC50 value of the brine shrimp cytotoxicity assay of the essential oil was observed at 0.81 μg/mL. The essential oil showed better activity on Gram-negative bacteria than Gram-positive bacteria and fungi. The proximate composition showed that root contained 5.29% ash, 2.01% protein, 54.09% crude fibre, 0.15% essential oil and 1.14% fatty oil for hot extract and 0.23% for cold extract on the dried basis. The palmitic (33.81 & 31.58%) and linoleic acid (30.03 & 23.79%) were the major saturated and unsaturated fatty acids in the cold and hot extracted root powder respectively. Ca (23,600 mg/kg), Mg (7620.33 mg/kg) and K (1286.15 mg/kg) were the most predominant elements followed by Ni (1187.30 mg/kg), Se (913.79 mg/kg), Li (317.84 mg/kg), Na (288.72 mg/kg) and Fe (206.88 mg/kg). The toxic elements were found to be within the permissible limit. Glutamic acid (19.37%), glycine (14.53%) and lysine (17.08%) were found as the major amino ...

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Section: Discussionmentioning

confidence: 99%

Chemical composition and pharmacological significance of Anethum Sowa L. Root

Saleh-e-In

Sultana

Rahim

et al. 2017

BMC Complement Altern Med

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“…The docking analysis of the lead compounds against the target protein shows that the phytochemicals such as Beta-Pinene, Beta-caryophyllene, Carvacrol, Cuminaldehyde, Isoginkgetin and Bilobetin possess 5 to 9 interactions with the core amino acid residues and present on the target ACE (Wong, 2016). The other selected compounds such as Linalool, Alpha-Thujone, Glycyrrhizic acid and Coumaric Acid classified as second with 2-4 interactions with the active site of ACE when compared to the standard drug Captopril which reveals 8 interactions over the target enzyme (Table 3) (Saleh, 2010).…”

Section: Resultsmentioning

confidence: 99%

Prediction of Anti-Hypertensive Potential of Siddha Formulation – Sagalanoi Chooranam against Angiotensin-Converting Enzyme (ACE): A Computational Approach

Srinivasan,

Subathra,

Kayalvizhi

et al. 2023

Intern. J. Zool. Invest.

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Hypertension, one of the top non-communicable diseases in the world, is a significant risk factor for the nephritic syndrome, coronary disease, heart failure, stroke and a host of other cardiovascular conditions which can be well-treated or controlled by Angiotensin Converting Enzyme (ACE) inhibitors. About 20-97% of hypertensive patients taking anti-hypertensive drugs experience side effects. Siddha's literature has numerous drugs capable of lowering hypertension which could be used as an alternative or supportive to anti-hypertensive drugs. Since hypertensive patients need medication throughout their lifetime to maintain their blood pressure, showing concern in choosing their regular medicines and their safety is mandatory. The present study investigatedq the anti-hypertensive activity of Sagalanoi Chooranam using computational analysis. The structure of the target protein (Angiotensin Converting Enzyme -PDB id 1O86) and selected ligands from the ingredients of Sagalanoi Chooranam were collected from databases. Docking studies were performed using Auto Dock Software Version 4. The performed docking studies showed satisfying results with the binding affinity energy of -7.80, -6.25, -6.19 and -6.00 kcal/mol for Glycyrehhtic Acid, biotin, Isoginkgetin and β-Caryophyllene, respectively against a target protein, Angiotensin Converting Enzyme. These bioactive compounds show better results than the standard drug, Captopril. On this basis, it was revealed that the phytochemicals of the ingredients of Siddha formulation Sagalanoi Chooranam were expected to show anti-hypertensive activity by inhibiting Angiotensin Converting Enzyme.

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“…Duggirala Red ( C. longa L.): 3-isopropyl-4-methyl-1-pentyn-3-ol (alcohol constituent) containing leaf and stem of Anethum sowa Roxb. ex , Fleming, used for flavoring of food, beverages and also for many medical preparations ( Saleh-e-in et al, 2010 ); 5,9-tetradecadiyne (unsaturated hydrocarbon) was found to be a major component of Ferula vesceritensis Coss. & Durieu ex Trab.…”

Section: Discussionmentioning

confidence: 99%

Variable Secondary Metabolite Profiles Across Cultivars of Curcuma longa L. and C. aromatica Salisb.

et al. 2021

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Background:Curcuma spp. (Zingiberaceae) are used as a spice and coloring agent. Their rhizomes and essential oils are known for medicinal properties, besides their use in the flavoring and cosmetic industry. Most of these biological activities were attributed to volatile and nonvolatile secondary metabolites present in the rhizomes of Curcuma spp. The metabolite variations among the species and even cultivars need to be established for optimized use of Curcuma spp.Objectives: We compared the phytochemical profiles of rhizomes and their essential oils to establish the variability among seven cultivars: five of Curcuma longa L. (Alleppey Supreme, Duggirala Red, Prathibha, Salem, Suguna) and two of C. aromatica Salisb. (Kasturi Araku, Kasturi Avidi). The GC-MS and LC-MS-based analyses were employed to profile secondary metabolites of these selected cultivars.Methods: Rhizomes of Curcuma spp. were subjected to hydro-distillation to collect essential oil and analyzed by GC-MS. The methanol extracts of fresh rhizomes were subjected to LC-MS analyses. The compounds were identified by using the relevant MS library databases as many compounds as possible.Results: The essential oil content of the cultivars was in the range of 0.74–1.62%. Several compounds were detected from the essential oils and rhizome extracts by GC-MS and LC-MS, respectively. Of these, 28 compounds (13 from GCMS and 15 from LCMS) were common in all seven cultivars, e.g., α-thujene, and diarylheptanoids like curcumin. Furthermore, a total of 39 new compounds were identified from C. longa L. and/or C. aromatica Salisb., most of them being cultivar-specific. Of these compounds, 35 were detected by GC-MS analyses of essential oils, 1,2-cyclohexanediol, 1-methyl-4-(1-methylethyl)-, and santolina alcohol, to name a few. The other four compounds were detected by LC-MS of the methanolic extracts of the rhizomes, e.g., kaempferol-3,7-O-dimethyl ether and 5,7,8-trihydroxy-2′,5′-dimethoxy-3′,4′-methylene dioxyisoflavanone.Conclusions: We identified and recorded the variability in the metabolite profiles of essential oils and whole rhizome extracts from the seven cultivars of Curcuma longa L. and C. aromatica Salisb. As many as 39 new metabolites were detected in these seven Indian cultivars of Curcuma spp. Many of these compounds have health benefits.

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Chemical Constituents of Essential Oil from <i>Anethum sowa</i> L. Herb (Leaf and Stem) Growing in Bangladesh

Cited by 9 publications

References 12 publications

Chemical composition and pharmacological significance of Anethum Sowa L. Root

Chemical composition and pharmacological significance of Anethum Sowa L. Root

Prediction of Anti-Hypertensive Potential of Siddha Formulation – Sagalanoi Chooranam against Angiotensin-Converting Enzyme (ACE): A Computational Approach

Variable Secondary Metabolite Profiles Across Cultivars of Curcuma longa L. and C. aromatica Salisb.

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