Chemical constituents of Euonymus alatus

Yan, Zhaohui; Han, Zhu‐Zhen; Hu, Xian-Qing; Liu, Qingxin; Zhang, Guoqing; Liu, Runhui; Li, Hui‐Liang

doi:10.1007/s10600-013-0598-9

Cited by 15 publications

(7 citation statements)

References 23 publications

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“…Euonymus alatus is a well-known plant utilized for medicinal purposes in some Asian countries for the treatment of illnesses such as cancer, stomach ache, wounds, asthma, hyperglycemia, and diabetic complications [20,21]. A preliminary study conducted by the authors showed that the extract of the Euonymus alatus leaf produced a moderate radical scavenging capacity as well as antioxidant enzyme-inducing activity (Figures 1 and 8).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice

Woo

Lim

et al. 2020

Antioxidants

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Euonymus alatus is considered to elicit various beneficial effects against cancer, hyperglycemia, menstrual discomfort, diabetic complications, and detoxification. The young leaves of this plant are exploited as food and also utilized for traditional medicine in East Asian countries, including Korea and China. Our preliminary study demonstrated that ethanolic extract from the Euonymus alatus leaf (EAE) exhibited the strongest antioxidant enzyme-inducing activity among more than 100 kinds of edible tree leaf extracts. This study investigated whether EAE could attenuate the cognitive deficits caused by oxidative stress in mice. Oral intubation of EAE at 100 mg/kg bw or higher resulted in significant improvements to the memory and behavioral impairment induced via i.p. injection of scopolamine. Furthermore, EAE enhanced the expression levels of hippocampal neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor in mice, activated the Nrf2, and the downstream heme oxygenase-1 (HO-1) a quintessential antioxidant enzyme. As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice

Woo

Lim

et al. 2020

Antioxidants

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Section: Resultsmentioning

confidence: 99%

“…In turn, 1 H NMR spectroscopy was particularly helpful for guiding the isolation of the known (7) and the new (8) DKPs, which existed in the inactive fraction C1 and showed diagnostic resonances in the 1 H NMR spectrum of the crude and the CHCl 3 subextract (Figures S2 and S3) [22]. Finally, two monoterpenes loliolide (5) and 5-epi-loliolide (6) [23,24] which did not appear in the MN because of their low MS 2 fragmentation intensity were also isolated from the active fraction C6 (Figure 3). The 1 H and 13 C NMR spectra (CD 3 OD) showed the presence of two carbonyl groups at δ C 167.7 (C-1) and 172.7 (C-7), plus two α-methine protons at δ H 4.48 (H-6) and 4.13 (H-9) that resonated at δ C 58.3 and 61.2, respectively, suggesting 8 to be a dipeptide [22].…”

Section: Purification and Structure Elucidationmentioning

confidence: 99%

Integrating Molecular Networking and 1H NMR Spectroscopy for Isolation of Bioactive Metabolites from the Persian Gulf Sponge Axinella sinoxea

Kouchaksaraee

Farimani

et al. 2020

Marine Drugs

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The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the metabolome and bioactivity profiles of the marine sponge Axinella sinoxea collected from the northeast coast of the Persian Gulf in Iran. The crude extract and its Kupchan subextracts were tested in multiple in-house bioassays, and the crude extract and its CHCl3-soluble portion showed in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium (Efm). A molecular networking (MN)-based dereplication strategy by UPLC-MS/MS revealed the presence of phospholipids and steroids, while 1H NMR spectroscopy indicated the presence of additional metabolites, such as diketopiperazines (DKPs). Integrated MN and 1H NMR analyses on both the crude and CHCl3 extracts combined with an antibacterial activity-guided isolation approach afforded eight metabolites: a new diketopiperazine, (-)-cyclo(L-trans-Hyp-L-Ile) (8); a known diketopiperazine, cyclo(L-trans-Hyp-L-Phe) (7); two known phospholipids, 1-O-hexadecyl-sn-glycero-3-phosphocholine (1) and 1-O-octadecanoyl-sn-glycero-3-phosphocholine (2); two known steroids, 3β-hydroxycholest-5-ene-7,24-dione (3) and (22E)-3β-hydroxycholesta-5,22-diene-7,24-dione (4); two known monoterpenes, loliolide (5) and 5-epi-loliolide (6). The chemical structures of the isolates were elucidated by a combination of NMR spectroscopy, HRMS and [α]D analyses. All compounds were tested against MRSA and Efm, and compound 3 showed moderate antibacterial activity against MRSA (IC50 value 70 μg/mL). This is the first study that has dealt with chemical and bioactivity profiling of A. sinoxea leading to isolation and characterization of pure sponge metabolites.

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“…It has plants all over China and is rich in resources. Many studies have shown that rutin, kaempferol and quercetin extracted from Euonymus have anti-oxidation effects and have good curative effect on diabetes [2][3][4]. Euonymus alatus also has antibacterial, anti-inflammatory, treatment of tumors, regulation of blood circulation, prevention of hyperlipidemia and other effects [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The extract of Euonymus alatus shoot

Guan

Sun

Wang³

et al. 2020

THERM SCI

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Euonymus alatus, is a common plant throughout China. Studies have shown that Euonymus alatus. can be used not only as an ornamental plant but also in medicine. In this paper, the active constituents of the Euonymus alatus. shoots collected in the field were studied to explore their development process and utilization value. By FT-IR, GC-MS, and TGA-DTG analysis of Euonymus alatus. shoot extract, it was found that Euonymus alatus. contains a large number of chemicals useful in the medical, spice, and chemical industries. It was also observed that Euonymus alatus. can be used as a bioenergy source with high utilization value.

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Chemical constituents of Euonymus alatus

Cited by 15 publications

References 23 publications

Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice

Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice

Integrating Molecular Networking and 1H NMR Spectroscopy for Isolation of Bioactive Metabolites from the Persian Gulf Sponge Axinella sinoxea

The extract of Euonymus alatus shoot

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