Chemical constituents of <i>Chaenomeles sinensis</i> twigs and their biological activity

Min, Joon Hong; Kim, Dong Hyun; Subedi, Lalita; Khan, Zahra; Choi, Sang Un; Kim, Sun Yeou; Kim, Chung Sub

doi:10.3762/bjoc.16.257

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Sugar analysis using LC–MS. In a manner similar to [ 21 ]. The monosaccharide ( 5 , 0.3 mg), obtained by hydrolysis, was dissolved in pyridine (0.5 mL), then ʟ-cysteine methyl ester hydrochloride (2 mg) was added.…”

Section: Methodsmentioning

confidence: 99%

Terpenoids from Glechoma hederacea var. longituba and their biological activities

Kim¹,

Ham²,

Khan³

et al. 2022

Beilstein J. Org. Chem.

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Glechoma hederacea var. longituba (common name: ground ivy) has been used for the treatment of asthma, bronchitis, cholelithiasis, colds, and inflammation. In the present study, three new sesquiterpene glycosides (1–3), two new diterpene glycosides (4 and 5), and four known compounds (6–9) were isolated from its MeOH extract. A structure elucidation was performed for the five new compounds (1–5) using 1D and 2D NMR, HRESIMS, DP4+ and ECD calculations, and chemical methods. All the isolates (1–9) were assessed for their antineuroinflammatory activities on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, nerve growth factor (NGF) secretion stimulation activities in C6 glioma cells, and cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 2 and 5–7 exhibited inhibitory effects on the NO production with IC50 values of 52.21, 47.90, 61.61, and 25.35 μM, respectively. Compound 5 also exhibited a significant stimulating effect on NGF secretion (122.77 ± 8.10%). Compound 9 showed potent cytotoxic activity against SK-OV-3 (IC50 = 3.76 μM) and SK-MEL-2 (IC50 = 1.48 μM) cell lines, while 7 displayed a strong cytotoxic activity against the SK-MEL-2 (IC50 = 9.81 μM) cell line.

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Section: Methodsmentioning

confidence: 99%

Terpenoids from Glechoma hederacea var. longituba and their biological activities

Kim¹,

Ham²,

Khan³

et al. 2022

Beilstein J. Org. Chem.

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“…In TCM, C. speciosa fruit is used to treat gastric disorders, dyspepsia, dysentery, enteritis, influenza, and rheumatic inflammation [103,104]. P. sinensis fruit has been used alone or in combination with other herbs to treat diarrhea, vomiting, muscle aches, and colds [105], as well as an antitussive, antiflatulent, and diuretic. It is also known for its expectorant activity [106] and its extract is traditionally used to treat viral infections [107].…”

Section: Biological Activity Of Quince Fruitsmentioning

confidence: 99%

Quinces (Cydonia oblonga, Chaenomeles sp., and Pseudocydonia sinensis) as Medicinal Fruits of the Rosaceae Family: Current State of Knowledge on Properties and Use

Kostecka-Gugała

2024

Antioxidants

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In recent years, the evaluation of many plant-derived compounds as potential new drugs or functional foods has become an active research topic. The morphological characteristics of quinces of the genera Cydonia sp., Chaenomeles sp., and Pseuocydonia sp. are largely similar, which is why these fruits are often confused. Although they have been appreciated in Asia for centuries as a valuable component of local ethnomedicine, they are less known in Western countries, and scientific knowledge about their health benefits remains fragmentary. This literature review summarizes studies on the content of chemical compounds responsible for the health-promoting and functional properties of the quince fruit. It focuses on the content of carotenoids, vitamins, minerals, and carboxylic acids, although the main emphasis is on the content and diversity of bioactive polyphenols, which are extremely abundant in these fruits. The quince fruits are rich in antioxidants and compounds with proven anti-inflammatory, anticancer, antiallergic, and immunomodulatory effects. Their phytochemicals effectively regulate glycemia and improve the blood lipid profile, suggesting potential antidiabetic and cardioprotective benefits. Analysis of chemical characteristics showed that the Chaenomeles fruits. are underestimated as functional food ingredients. Studies on the molecular effects of their bioactive compounds and species-specific genomic analyses are sorely lacking in the scientific literature.

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“…In TCM, C. speciosa fruit is used to treat gastric disorders, dyspepsia, dysentery, enteritis, influenza, and rheumatic inflammation [108,109]. P. sinensis fruit has been used alone or in combination with other herbs to treat diarrhea, vomiting, muscle aches, and colds [110], as well as an antitussive, antiflatulent, and diuretic. It is also known for its expectorant activity [111] and its extract is traditionally used to treat viral infections [112].…”

Section: Biological Activity Of Quince Fruitsmentioning

confidence: 99%

Quinces (Cydonia, Chaenomeles and Pseudocidonia) as Less Distinguishable Medicinal Fruits of the Rosaceae Family. Current State of Knowledge on Properties and Use

Kostecka-Gugała

2023

Preprint

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In recent years, the evaluation of many plant-derived compounds as potential new drugs or functional foods has become an active research topic. The characteristics of quinces of the genera Cydonia, Chaenomeles and Pseuocydonia are largely similar, which is why these fruits are often confused. Although they have been appreciated in Asia for centuries as a valuable component of local ethnomedicine, they are less known in Western countries and scientific knowledge about their health benefits remains fragmentary. This literature review presents the bioactive compounds of these fruits with special emphasis on antioxidants. Most space has been devoted to the presentation of the biological activities and potential medical applications of the fruits due to their antioxidant, anti-inflammatory, anticancer, cardioprotective and antidiabetic effects.

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Chemical constituents of Chaenomeles sinensis twigs and their biological activity

Cited by 6 publications

References 39 publications

Terpenoids from Glechoma hederacea var. longituba and their biological activities

Terpenoids from Glechoma hederacea var. longituba and their biological activities

Quinces (Cydonia oblonga, Chaenomeles sp., and Pseudocydonia sinensis) as Medicinal Fruits of the Rosaceae Family: Current State of Knowledge on Properties and Use

Quinces (Cydonia, Chaenomeles and Pseudocidonia) as Less Distinguishable Medicinal Fruits of the Rosaceae Family. Current State of Knowledge on Properties and Use

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