Chemical Constituents of<i>Luffa acutangula (L.)</i>Roxb Fruit

Suryanti, Venty; Marliyana, Soerya Dewi; Astuti, Ika Yuni

doi:10.1088/1757-899x/193/1/012050

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…There are 6 ligands anchored to each target protein, which are described in the table 2. The GC-MS of the analysis L. acutangula fraction resulted in the identification of 6 compounds (Suryanti et al, 2017). The preparation is done through AutoDock Tools by separating the native ligand and water molecules, as well as adding hydrogen atoms.…”

Section: Research Methods Preparation Of Macromolecules and Ligandsmentioning

confidence: 99%

Molecular Docking and Pharmacokinetic Prediction of Potential Compounds from Luffa acutangula as Antidiabetic Candidates

Hasan,

Herowati,

Widodo

2023

Pharm. : j. farm. Indones.

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Luffa acutangula is commonly used, but its considerable potential as an alternative treatment for diabetics with a molecular target action is not yet known. Preliminary study of bioinformatics to decipher the compounds of L. acutangulaable to interact with the protein targets of antidiabetic therapy. This study aims to identify the potential compounds of L. acutangula that are thought to interact with the insulin receptor, aldose reductase, and PTP-1B, as well as provide predictions of pharmacokinetics and toxicity. Molecular docking was conducted in AutoDock 4.2.6 with the stages initiated by the preparation of macromolecules (PDB ID: 1IR3; 2PEV; 4Y14) and ligands, molecular docking, and visualization. The pharmacokinetic profiles are predictable by using the Swiss ADME and toxicity estimates by Toxtree. The results showed that cucurbitacin B, cucurbitacin E, oleanolic acid, catechin, ferulic acid and apigenin are the most potential compounds to interact with the macromolecular with a binding energy response similar to the native ligand. Pharmacokinetic predictions show that cucurbitacin B and cucurbitacin E deviate from one Lipinski rule (BM> 500), do not diffuse into the blood brain barrier, are not CYP450 inhibitors, as well as classified as Pgp substrates. The prediction of toxicity indicates that all potential compounds are classified as high toxicity compounds with a risk of narcosis, except oleanolic acid and ferulic acid. These compounds are not genotoxic or non-genotoxic carcinogens.

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Section: Research Methods Preparation Of Macromolecules and Ligandsmentioning

confidence: 99%

Molecular Docking and Pharmacokinetic Prediction of Potential Compounds from Luffa acutangula as Antidiabetic Candidates

Hasan,

Herowati,

Widodo

2023

Pharm. : j. farm. Indones.

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“…Six compounds were isolated and analyzed from ethanolic fruit extract using GC-MS named as: 2,3-dihydro,3,5-dihydroxy-6-methyl-(4H)-pyran-4-one (44) ; 3,7,11,15-tetramethyl-2-hexadecen-1-ol (45) ; (3β, 20R)-cholest-5-en-3-ol (46) ; n -hexadecanoic acid (08) ; 9,12,15-octadecatrienoic acid methyl ester (47) and citronellyl tiglate (48) (Figure 6) (Suryanti et al, 2017). …”

Section: Phytochemistrymentioning

confidence: 99%

Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Shendge

Belemkar

2018

Front. Pharmacol.

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Luffa acutangula (Cucurbitaceae), a perennial plant grows mainly in India, Southeast Asia, China, Japan, Egypt, and other parts of Africa, it is widely used in the traditional Indian medicinal system to treat various health conditions. The plant has been used in jaundice, diabetes, hemorrhoids, dysentery, headache, ringworm infection, and leprosy. More than 50 chemical compounds have been isolated from a plant which mainly comprises flavonoids, anthraquinones, proteins, fatty acids, saponin triterpene, volatile components, and other phytoconstituents. Crude extract of plant and its isolated compounds possess broad pharmacological activities such as antidiabetic, hepatoprotective, antiulcer, anticancer, immunomodulatory, antihyperlipidemic, antioxidant, antimicrobial, CNS depressant, analgesic, and anti-inflammatory. The toxicological evaluation in preclinical studies reported safety of the plant for human consumption, but comprehensive evaluation in clinical studies is required. However, further investigation is necessary for transformation of experience based treatment of plant into evidence based information. Evaluation of pharmacological activity with indicative biomarkers will help to reveal the mechanism of action of chemical constituents of plant extract. The data from preclinical studies recommends clinical evaluation of safety and efficacy of the plant. The current paper summarizes up-to-date information about a review of the traditional uses, phytochemistry, pharmacological activities, and toxicology to highlight the future prospects of the plant.

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“…The clarity range from clear to a whitish translucent. The polymers are used between 0.5-15% and in most of the cases they are usually at the concentration between 0.5-2% [14][15][16] . Luffa acutangula (Family: Cucurbitaceae) is commonly known as Ridge gourd.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of anti-acne gel containing Luffa acutangula Seeds extract

Thote,

Dhoble,

Baheti

2023

Int. J. Herb. Med.

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Acne is an inflammatory skin disease that occurs due to blockages in polysebase and inflammation that are caused by bacteria. Propionibacterium acnes are common pus-forming microbes responsible for the development of acne. Medicinal plants play an important role in the development of potent therapeutic agents. Plant based drugs provide outstanding contribution to modern therapeutics as a source of many valuable secondary metabolites which serves as plant defense mechanisms against predator such as microorganism, insects and herbivores which have been proved to be potentially active compounds. There is a tremendous increase in search of antimicrobial plant extracts due to the fact that the resistance offered against antibiotic by the microorganism, in short the effective life span of any antibiotic is limited. The herbal gel preparation was formulated based upon traditional knowledge and emphasis was to formulate a stable and functionally effective. The advantage of this gel is reduced adverse effects unlike synthetic drugs. The preliminary phytochemical screening of hydroalcoholic extract of Luffa acutangula seeds showed the presence of Carbohydrates, Amino acids, Proteins and tannins. The formulations were tested for the anti-acne activity by well diffusion method against Propionibacterium acnes. Results showed that the gels were non-irritant, stable and possess anti-acne activity. The efficacy when tested with a standard was almost same to that of marketed gel. This suggests that seeds of Luffa acutangula, have potential against acne causing bacteria and hence they can be used in topical anti-acne preparations and may address the antibiotic resistance of the bacteria.

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Chemical Constituents ofLuffa acutangula (L.)Roxb Fruit

Cited by 6 publications

References 7 publications

Molecular Docking and Pharmacokinetic Prediction of Potential Compounds from Luffa acutangula as Antidiabetic Candidates

Molecular Docking and Pharmacokinetic Prediction of Potential Compounds from Luffa acutangula as Antidiabetic Candidates

Therapeutic Potential of Luffa acutangula: A Review on Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects

Development and evaluation of anti-acne gel containing Luffa acutangula Seeds extract

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