Chemical Constituents of Parasenecio quinquelobus

Muhammad, Ishaq; Wang, Rui-bin; Xiao, Yongzhen; Xie, Yunying; Hassan, Syed Shams ul; Wu, Gaolin; Qian, Xiaohong; Jin, Hui‐Zi

doi:10.1007/s10600-021-03316-y

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Medicinal plants is a rich source of bioactive compounds with diverse pharmacological potentials ( Mir et al, 2019 ; Muhammad et al, 2021a ; Muhammad et al, 2021b ; Muhammad et al, 2021c ). Polyphenols represent greatly varying group of compounds extensively distributed in plants ( Ovais et al, 2018b ; Zohra et al, 2019 ).…”

Section: Plant Polyphenols: Sources and Chemistrymentioning

confidence: 99%

Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

Kabra

Garg²,

Brimson³

et al. 2022

Front. Pharmacol.

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Depression is a condition characterized by low mood and an aversion to activity, that causes behavioral problems, poor quality of life and limits daily life activities. It is considered as the fourth leading cause of disability worldwide. Selective Serotonin Reuptake Inhibitors (SSRIs) Monoamine Oxidase (MAO) inhibitors, Tricyclic Antidepressants (TCAs), and atypical antidepressants are some of the conventional medications used to treat depression. However, only about half of patients with major depressive disorder (MDD) respond effectively to first-line antidepressant therapy. Additionally, there are a number of drawbacks to standard antidepressants, such as anti-cholinergic side effects, drug-drug interactions, and food-drug interactions, which prompts researchers to look at alternative approaches to the treatment of depression. Medicinal plants and their metabolites are extensively tested for their efficacy against depression. Electronic databases such as Google scholar, Science Direct, SciFinder and PubMed were used to search relevant literature on the role of polyphenols in depression. Plants-derived Polyphenols represent a major class of compounds extensively distributed in plants. Number of polyphenols have demonstrated antidepressant activity, among which berberine, piperine, curcumin, naringenin, ascorbic acid and ginsenosides are extensively evaluated. The medicinal plants and their derived compounds mediated synthesized green nanoparticles have also exhibited considerable efficacy in the management of depression. The therapeutic effects of these phytochemicals is mediated via differentiation and inhibition of neuronal cell apoptosis, promotion of neuronal cell survival and modulation of key neurotransmitters. The aim of this study is to review compressively the chemical, pharmacological and neurological evidence showing the potential of polyphenols in depression.

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Section: Plant Polyphenols: Sources and Chemistrymentioning

confidence: 99%

Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

Kabra

Garg²,

Brimson³

et al. 2022

Front. Pharmacol.

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“…23 Dihydroxylation of the exomethylene group of 26 generated ent-3β-acetoxykaur-16β,17-diol (27) as a single diastereomer. 24 Hydrolysis of the C16 ester group of 9 followed by a TBS deprotection and an acetylation produced fritillebic acid (28) with a 13:1 dr at C16. 25 Esterification of 28 with 27 afforded fritillebin B (29).…”

Section: S3mentioning

confidence: 99%

Reductive Radical Annulation Strategy toward Bicyclo[3.2.1]octanes: Synthesis of ent-Kaurane and Beyerane Diterpenoids

Zhuo

Zhu

et al. 2021

J. Am. Chem. Soc.

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Here we report a general [3 + 2] radical annulation that allows the facile construction of bicyclo[3.2.1]octane motifs in ent-kaurane-and beyerane-type diterpenoids. This radical annulation is difficult to control but was realized by harnessing an unprecedented and counterintuitive effect of TEMPO. Eleven natural products with a wide array of oxidation states are easily prepared, demonstrating the powerful utility of this straightforward synthetic strategy.

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“…Parasenecio species have long been used as traditional Chinese medicines due to their significant bioactivities, such as their anti-inflammatory, antitussive, and antimicrobial properties [13,14]. Former studies of Parasenecio species mainly comprised medicinal and pharmacological studies [13,14]. However, few studies have reported the plastid genomes and phylogenetic analysis of species of Parasenecio.…”

Section: Introductionmentioning

confidence: 99%

Phylogenomic Analysis of Two Species of Parasenecio and Comparative Analysis within Tribe Senecioneae (Asteraceae)

et al. 2023

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The genus of Parasenecio (Senecioneae) comprises about 70 species of high medicinal value. In this study, the plastomes of Parasenecio palmatisectus and P. latipes were newly sequenced using high-throughput sequencing technology and compared with those of eight other species in Senecioneae. The complete chloroplast (cp) genomes were 151,185 bp in P. latipes with 37.5% GC and 151,263 bp in P. palmatisectus with 37.5% GC. We predicted 133 genes, including 37 tRNA genes, 86 protein-coding genes, 8 rRNA genes, and 2 pseudogenes (ycf1 and rps19). A comparative genomic analysis showed that the complete cp genome sequences of Parasenecio species and their related species were relatively conserved. A total of 49 to 61 simple sequence repeats (SSRs) and 34 to 46 interspersed repeat sequences were identified in the 10 Senecioneae species of plastomes. Within the tribe Senecioneae, single-copy regions were more variable than inverted repeats regions, and the intergenic regions were more variable than the coding regions. Two genic regions (ycf1 and ccsA) and four intergenic regions (trnC-GCA-petN, ycf1-trnN-GUU, psaI-ycf4, and rpl32-trnL-UAG) were identified as highly valuable plastid markers. A phylogenetic analysis under maximum likelihood revealed that the two Parasenecio species are sister to the genera of Ligularia and Sinosenecio in the tribe Senecioneae. This study also contributes to the super-barcode, phylogenetic, and evolutionary studies of Parasenecio plants.

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Chemical Constituents of Parasenecio quinquelobus

Cited by 6 publications

References 11 publications

Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

Reductive Radical Annulation Strategy toward Bicyclo[3.2.1]octanes: Synthesis of ent-Kaurane and Beyerane Diterpenoids

Phylogenomic Analysis of Two Species of Parasenecio and Comparative Analysis within Tribe Senecioneae (Asteraceae)

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