Chemical Constituents of Petroleum Ether Extract from Nervilia foadii

Zhu, Hua Long; Fu, Peng; Zou, Deng Feng

doi:10.3923/pjbs.2006.1556.1558

Cited by 6 publications

(2 citation statements)

References 0 publications

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“…1 H‐NMR(400 MHz, DMSO‐ d 6 ): δ H 0.85 (t, J = 6.7 Hz, 3H), 1.23–1.28(m, 20H), 2.28(t, J = 7.4 Hz,2H), 4.02(dd, J = 11.1,4.2 Hz, 1H), 5.32(q, J = 4.8 Hz, 1H); 13 C‐NMR(100 MHz, DMSO‐ d 6 ): δ C 173.23(C‐1), 33.73(C‐2), 24.71(C‐3), 26.86(C‐4), 28.55–29.36(C‐5–8, 12–16), 129.91(C‐9), 129.88(C‐10), 31.56(C‐11), 22.38(C‐17), 14.23(C‐18), 69.52(C‐1 , ), 65.75(C‐2 , ), 62.86(C‐3 , ). Analysis of NMR was consistent with literature (Wang, Feng, He, Sun, & Chen, 2013; Zhu, Zhang, Wang, & Sun, 2014), and allowing us to determine the structure of compound 3 as glyceryl oleate.…”

Section: Spectroscopic Datasupporting

confidence: 73%

“…The 1 H‐NMR and 13 C‐NMR data of these compounds are shown in the supporting information. The compounds were identified as 9,12‐heptadecadienoic acid glyceride (compound 1 was peak 4 of Figure 1) (Liu, Mei, & Cheng, 2005), nonadecanoic acid methyl ester (compound 2 was peak 5 of Figure 1) (Zhao, Yang, Wang, Zhao, & Zhao, 2014), glyceryl oleate (compound 3 was peak 6 of Figure 1) (Wang, Feng, He, Sun, & Chen, 2013; Zhu, Zhang, Wang, & Sun, 2014), 13,16,19‐eicosatrienoic acid (compound 4 was peak 7 of Figure 1) (Zhang, 2012), 9,12,15‐octadecatrienoic acid glyceride (compound 5 was peak 9 of Figure 1) (Lu, 2012), linoleic acid (compound 6 was peak 10 of Figure 1) (Zhaori, Wu, Naren, & Wang, 2016), hexadecanoic acid (compound 7 was peak 12 of Figure 1) (Zheng et al, 2019), oleic acid (compound 8 was peak 13 of Figure 1) (Yang et al, 2018), octadecanoic acid (compound 9 was peak 14 of Figure 1) (Zhang et al, 2018). They were isolated from P. Americana for the first time except for glyceryl oleate (3).…”

Section: Resultsmentioning

confidence: 99%

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Identification of anti–hepatic fibrosis components in Periplaneta americana based on spectrum–effect relationship and chemical component separation

Zhao

Xie

et al. 2021

Biomedical Chromatography

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Periplaneta americana (PA) is used as a traditional medicine for hepatic diseases such as hepatic fibrosis in China. However, the relationship between the corresponding therapeutic effect and the chemical composition is still unclear. In this study, spectrum-effect relationship and chemical component separation were used to discover the potential of anti-hepatic fibrosis components of PA. The fingerprints of 10 batches of samples were established using HPLC, and the anti-hepatic fibrosis effect was determined using HSC-T6 cells. The spectrum-effect relationship between common peaks and efficacy values was established using partial least squares analysis. Partial peaks in the fingerprints were identified, including X 4 (9,12-heptadecanedenoic acid glyceride), X 5 (nonadecanoic acid methyl ester), X 6 (glyceryl oleate), X 7 (13,16,19-eicosatrienoic acid), X 9 (linoleic acid), X 10 (9,12,15-octadecatrienoic acid glyceride), X 12 (hexadecanoic acid), X 13 (oleic acid), and X 14 (octadecanoic acid), and their anti-hepatic fibrosis activity was tested to verify the results of spectrum-effect relationships. The results showed that X 4 , X 6 , X 7 , and X 10 were the active ingredients of PA. This work successfully identified the partial anti-hepatic fibrosis components of PA, which can be used to explain the material basis for the PA anti-hepatic fibrosis effect.

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Section: Spectroscopic Datasupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Identification of anti–hepatic fibrosis components in Periplaneta americana based on spectrum–effect relationship and chemical component separation

Zhao

Xie

et al. 2021

Biomedical Chromatography

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7-O-Methylkaempferol and -quercetin Glycosides from the Whole Plant of Nervilia fordii

et al. 2009

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Five new 7-O-methylkaempferol and -quercetin glycosides, namely, nervilifordins A-E (1-5), were isolated from the whole plant of Nervilia fordii, together with seven known flavonoids (6, 7, and 9-13) and one known coumarin (8). Their structures were elucidated on the basis of extensive spectroscopic analyses, including HSQC, HMBC, ROESY, and chemical methods. Compounds 1-3 and 6-13 were evaluated for their anti-herpes simplex virus 1 (HSV-1) activity and cytotoxicity on African green monkey kidney cells (Vero cells) in vitro. Of the tested compounds, only esculetin (8) exhibited antiviral activity against HSV-1, while the aglycones (11-13) showed stronger cytotoxicity on Vero cells than their glycosides (1-3, 6, and 7).

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Five new flavonoid glycosides fromNervilia fordii

Qiu

Jiao

Xie

et al. 2013

Journal of Asian Natural Products Research

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Five new flavonoid glycosides, namely nervilifordins F-J (1-5), were isolated from the 60% EtOH extract of the aerial parts of Nervilia fordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9-12). The structures of new compounds were elucidated on the basis of 1D and 2D NMR and MS studies. Their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages. Compounds 2 and 5 showed interesting inhibition effects with their EC50 values of 15.15 μM and 14.80 μM, respectively.

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Chemical Constituents of Petroleum Ether Extract from Nervilia foadii

Cited by 6 publications

References 0 publications

Identification of anti–hepatic fibrosis components in Periplaneta americana based on spectrum–effect relationship and chemical component separation

Identification of anti–hepatic fibrosis components in Periplaneta americana based on spectrum–effect relationship and chemical component separation

7-O-Methylkaempferol and -quercetin Glycosides from the Whole Plant of Nervilia fordii

Five new flavonoid glycosides fromNervilia fordii

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