Chemical Constituents of Plants from the Genus <i>Phlegmariurus</i>

Yang, Yiyu; Wang, Zhichong; Wu, Ji‐Chun; Chen, Ye‐Gao

doi:10.1002/cbdv.201500043

Cited by 18 publications

(7 citation statements)

References 18 publications

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“…These conditions impose great monetary and emotional costs on patients and their caregivers. HupA is approved as the drug of choice for Alzheimer's disease (AD) treatment in China and as a dietary supplement in the United States [29,30], as intake can improve AD pathogenesis [31]. Due to its potent AChEI activity, HupA is used as a treatment for AD.…”

Section: Introductionmentioning

confidence: 99%

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Friedli

Inestrosa

2021

Molecules

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Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for centuries in Chinese folk medicine to treat dementia. The effects of this alkaloid have been attributed to its ability to inhibit the cholinergic enzyme acetylcholinesterase (AChE), acting as an acetylcholinesterase inhibitor (AChEI). The biological functions of HupA have been studied both in vitro and in vivo, and its role in neuroprotection appears to be a good therapeutic candidate for Alzheimer´s disease (AD). Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenues, such as the Wnt signaling, the pre- and post-synaptic region mechanisms (synaptotagmin, neuroligins), the amyloid precursor protein (APP) processing, the amyloid-β peptide (Aβ) accumulation, and mitochondrial protection. Our goal is to provide an integrated overview of the molecular mechanisms through which HupA affects AD.

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Section: Introductionmentioning

confidence: 99%

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Friedli

Inestrosa

2021

Molecules

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“…The dichloromethane-methanol (1 : 1) extract of plant materials was analysed using chromatographic techniques including preparative HPLC to afforded 15 compounds, one of which is new. From the isolated compounds, two of them (1-2) are sesquiterpene acids and thirteen of them (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) are sesquiterpene lactones. Compounds 6 and 7 were found in large quantity and hence considered as marker compounds for the identification of I. confertiflora form other species of the genus.…”

Section: Discussionmentioning

confidence: 99%

“…[7] A review of literature has shown that different secondary metabolites including monoterpenes, sesquiterpenes, diterpenes, flavonoids, and glycolipids have been reported from this genus. [8] Cyclic sesquiterpenes were found to be the predominant constituents within the genus. Though several species in the genus Inula have been scientifically studied for their phytochemical constituents and pharmacological activities, reports on the phytochemical constituents of I. confertiflora are limited.…”

Section: Introductionmentioning

confidence: 99%

Sesquiterpene Acids and Lactones from Inula Confertiflora with their Antibacterial Activities

Ahmed,

Desta,

Wami

et al. 2024

Chemistry & Biodiversity

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The phytochemical investigation of the leaves of Inula confertiflora, a medicinal plant endemic to Ethiopia, led to the isolation of 15 terpenoids; 1β‐hydroxy‐α‐costic acid (1), 3α‐hydroxycostic acid (2), isotelekin (3), asperilin (4), carabrone (5), carpesioline (6), graveolide (7), inuviscolide (8), 8‐epi‐inuviscolide (9), 1β,4β‐dihydroxy‐5α(H)‐guaia‐10(14),11(13)‐dien‐8α,12‐olide (10), isoinuviscolide (11), 4β,10β‐dihydroxy‐5α(H)‐1,11(13)‐guaidien‐8α,12‐olide (12), 4β,10β‐dihydroxy‐1β(H)‐5α(H)‐guai‐11(13)‐en‐8α,12‐olide (13), 4β,10α‐dihydroxy‐1β(H)‐5α(H)‐guai‐11(13)‐en‐8α,12‐olide (14), 4β,10α‐dihydroxy‐1α(H)‐5α(H)‐guai‐11(13)‐en‐8α,12‐olide (15). Herein, structural elucidation and full NMR data for compound 1 are presented for the first time. The structures were elucidated using NMR, HRESIMS, and by comparison with literature data. The relative configurations were defined by NOESY correlations and single‐crystal X‐ray crystallography. Herein, crystallography data of 6 and 7 were reported for the first time. The antibacterial efficacy of some of the isolated compounds was evaluated against two commonly dispersed environmental strains of Escherichia coli and Staphylococcus aureus. Compounds 1, 3, 6, 7, and 8 exhibited moderate antibacterial activities against the tested organisms. The chemotaxonomic significance of compounds is discussed.

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“…Extracts from Huperzia serrata (Lycopodiaceae) inhibited AChE activity and ameliorated the cognitive impairment of AD mice [ 165 ]. A number of lycopodium alkaloids have been isolated and synthesized as potent AChE inhibitors [ 166 ]. Extracts from Crocus sativus (Iridaceae) exhibited moderate inhibitory activity against AChE.…”

Section: Neuroprotective Mechanisms Of Natural Products For Admentioning

confidence: 99%

Neuroprotective Natural Products for Alzheimer’s Disease

Chen

Drew

Berney

et al. 2021

Cells

137

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Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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Chemical Constituents of Plants from the Genus Phlegmariurus

Cited by 18 publications

References 18 publications

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Sesquiterpene Acids and Lactones from Inula Confertiflora with their Antibacterial Activities

Neuroprotective Natural Products for Alzheimer’s Disease

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