Chemical Constituents of Stems and Leaves of Tagetespatula L. and Its Fingerprint

Abstract

Tagetespatula L. is a widely cultivated herbal medicinal plant in China and other countries. In this study, two new 2, 3-dihydrobenzofuran glucosides (1, 2) and fourteen known metabolites (3–16) were isolated from the stems and leaves of T. patula (SLT). The chemical structures of the isolated compounds were characterized comprehensively based on one- and two-dimensional NMR spectroscopy and high resolution mass spectrometry. Absolute configurations of compounds 1 and 2 were determined by ECD calculations. Compounds 1 and 2 exhibited moderate in vitro inhibitory activities against human gastric cancer cell lines (AGS) with IC50 values of 41.20 μmol/L and 30.43 μmol/L, respectively. The fingerprint profiles of stems and leaves of T. patula with three color types of flowers (Janie Yellow Bright, Jinmen Orange, Shouyao Red and Yellow color) were established by high-performance liquid chromatography (HPLC). Ten different batches of stems and leaves were examined as follow: Shouyao Red and Yellow color (1, 2, 3), Janie Yellow Bright (4, 5, 6, 7) and Jinmen Orange (8, 9, 10). Twenty-two common peaks were identified with similarity values ranging from 0.910 to 0.977. Meanwhile, the average peak area of SLT in the three types of flowers was different and it was the highest in Janie Yellow Bright.

In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk

“…Natural products can be considered as the main source of antimicrobial and anticancer compounds [5]. e activity of natural products either originated from plants [5][6][7], marines [8,9] or fungi [10][11][12][13][14] is owned to a diversity of secondary metabolites that belong to various chemical classes such as flavonoids [15][16][17], saponins [6,18], pyrones [19], isochromenes [20], and alkaloids [21].…”

Traditional ancient Egyptian medicine: A review

“…Humans relied on nature as the main source of treatments since the dawn of history. In order to fulfill this need, he used different sources such as plants ( Han et al, 2019 , Metwaly et al, 2019 , Wang et al, 2019 ), marines ( El-Demerdash et al, 2021 , Sperstad et al, 2011 ), and microbes( Metwaly, 2019 , Metwaly et al, 2014a , Metwaly et al, 2017 ). Similarly, the ancient Egyptian pharmacopeia comprised a wide diversity of treatments, these treatments include minerals, metals, animals, and plant sources.…”

In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (Mpro)

“…Natural secondary metabolites are a major source of anti-infective drugs. These metabolites could be originated from plants [ 16 , 17 ], marine [ 18 , 19 ], or microbial sources [ 20 , 21 , 22 ], and found to belong to various types such as saponins [ 23 , 24 ], alkaloids [ 25 ], pyrones [ 26 ], isochromenes [ 27 ], diterpenes[ 28 ], flavonoids [ 29 , 30 ], and isoflavonoids [ 31 ].…”