Chemical constituents of the medicinal plant Indigofera spicata Forsk (Fabaceae) and their chemophenetic significance

The phytochemical investigation of a previously unstudied species of the genus Indigofera, I. atriceps Hook.f. was undertaken and two new phenolic compounds, atricephenols A (1) and B(2) were isolated, along with nine known secondary metabolites viz., (-)-melilotocarpan D (3), genistein (4), melilotocarpan A (5), maackiain (6), p-hydroxybenzaldehyde (7), bornesitol (8), βsitosterol (9), sitosterol-3-O--D-glucopyranoside (10) and stigmasterol-3-O--Dglucopyranoside (11). Their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS, and by comparing their data with those reported in the literature.Compounds 1, 4, 7-11 were tested for their antibacterial efficacies and for their potential to inhibit the enzyme urease. Compounds 7 and 9 showed significant antibacterial activity against Salmonella typhi (ZOIs of 13 and 15 mm, respectively), while the best urease inhibition was measured for compound 9 with an IC 50 value of 18.6 µM, which is higher than that of the potent inhibitor, thiourea (IC 50 = 21.5 µM).

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Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae)

Mouafon

Mountessou

Lateef

et al. 2022

Natural Product Research

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Enzyme Urease Activity and Phytochemical Investigation of the Leaves of Baissea Mortehanii (Apocynaceae)

Lidwine,

Fanny-Aimee,

Caroline

et al. 2024

SJC

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The phytochemical investigation of a previously unstudied species of the genus Apocynaceae, Baissea mortehanii de Wild was undertaken and eight known secondary metabolites were isolated from leaves of this plant including one alkaloid, N-Feruloyltryptamine (1); one aromatic ester, Dibutyl phthalate (2); two flavonoids, Genistein (3) and Gerontoisoflavone A (4), four sterols, β-Sitosterol (5), Sitosterol-3-O-β-D-glucopyranoside (6), Stigmasterol (7) and Stigmasterol-3-O-β-D glucopyranoside (8). The structures of compounds were determined by means of spectroscopic methods :NMR analysis (1H and13C NMR, 1H-1H-COSY, HSQC, HMBC), spectrometric methods such as UV, IR, ESI-MS, EI, and by comparing their data with those reported in the literature. All the isolated compounds were tested for their potential to inhibit the enzyme urease. Urease activity was determined by measuring ammonia production using the indophenol method and thiourea was used as standard inhibitor of urease. Compounds 5 and 7 showed the best urease inhibition with an IC50 value 17. 2 and 18.5 µM respectively, which is higher than that of the potent inhibitor, thiourea (IC50 = 21.5 µM); Compounds 3, 4, 6 and 8 showed a good urease inhibition with an IC50 value 26.9, 29.7, 32.8 and 34.3 µM respectively; Compounds 1 and 2 showed a moderate urease inhibition with an IC50 value 49.1 and 46.8 µM respectively.

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Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents

Zhou

et al. 2022

CTMC

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: Gram-positive and Gram-negative pathogens are able to evade the host immune system, persist within the human host, and lead to severe disease and even death. At present, bacterial infections are one of the leading causes of morbidity and mortality across the world. Development of novel antibacterial agents still represents a challenging endeavor, which is mainly attributed to the continuous emergence of more virulent and drug-resistant pathogens. Benzofuran constitutes the core of diverse pharmacologically active compounds, and there are a variety of approved benzofuran-based drugs in the market or currently going through different clinical phases or registration statuses. Benzofurans could exert antibacterial activity through various mechanisms and possess pronounced activity, so benzofuran is a useful skeleton for the discovery of novel antibacterial agents. This review focuses on the recent advancement of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents, covering articles published between January 2015 and July 2021. The chemical structures and structure-activity relationships are also discussed.

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Chemical constituents of the medicinal plant Indigofera spicata Forsk (Fabaceae) and their chemophenetic significance

Cited by 4 publications

References 28 publications

Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae)

Atricephenols A and B, two phenolic compounds from Indigofera atriceps Hook.f. (Fabaceae)

Enzyme Urease Activity and Phytochemical Investigation of the Leaves of Baissea Mortehanii (Apocynaceae)

Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents

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