Chemical Constituents of the Plants from the Genus <i>Phyllanthus</i>

Qi, Weiyan; Liu, Hua; Gao, Kun

doi:10.1002/cbdv.201200244

Cited by 27 publications

(15 citation statements)

References 134 publications

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“…Representative of the family Phyllanthaceae, Phyllanthus is a large genus containing over 700 species distributed throughout parts of South America, Asia, and Africa, with some members used in systems of Asian traditional medicine (Mabberley, 2008; Qi et al, 2014). For example, the fruits of Phyllanthus emblica and the whole plant of P. urinaria are utilized as traditional Chinese medicines to treat cancer and infectious diseases (Chang et al, 2003; Huang et al, 2006; Luo et al, 2011; Qi et al, 2014; Xu et al, 1996; Zhang et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…For example, the fruits of Phyllanthus emblica and the whole plant of P. urinaria are utilized as traditional Chinese medicines to treat cancer and infectious diseases (Chang et al, 2003; Huang et al, 2006; Luo et al, 2011; Qi et al, 2014; Xu et al, 1996; Zhang et al, 2001). Both P. emblica and P. reticulatus have use in Ayurvedic traditional medicine in the Indian sub-continent for the treatment of cancer, diabetes, inflammation, and other diseases (Sharma and Kumar, 2013; Singh et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Phyllanthus species produce a diverse array of bioactive compounds, with lignans as one of the major groups of secondary metabolites elaborated (Qi et al, 2014). Several diphyllin-type arylnaphthalene lignans have been characterized from this genus and found to exhibit potent cytotoxicity toward a number of human cancer cell lines (Ren et al, 2014; Tuchinda et al, 2006, 2008; Wu and Wu, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis

et al. 2015

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A dichapetalin-type triterpenoid and a dibenzylbutyrolactone-type lignan, together with five known lignans, a known aromatic diterpenoid, and a known acylated phytosterol, were isolated from the aerial parts of Phyllanthus songboiensis, collected in Vietnam. Their structures were determined by interpretation of the spectroscopic data, and the inhibitory activity toward the HT-29 human colon cancer cells of all isolates was evaluated by a cytotoxicity assay. The known arylnaphthalene lignan, (+)-acutissimalignan A, was highly cytotoxic toward HT-29 cells, with an IC50 value of 19 nM, but this compound was inactive as a DNA topoisomerase IIα (topo IIα) poison. The known phytosterol, (−)-β-sitosterol-3-O-β-D-(6-O-palmitoyl)glucopyranoside, was found to stimulate natural killer (NK) cells at a concentration of 10 μM in the presence of interleukin 12 (IL-12).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis

et al. 2015

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“…A comparison of the physicochemical and spectral data with those of standards and the literature identified the known compounds gallic acid (3), glucogallin (4), 1,6-di-Ogalloyl-E-D-glucose (5), 3,4,6-tri-O-galloyl-E-D-glucose (6), mucic acid 2-O-gallate (7), mucic acid 2-O-gallate 1,4-lactone (8), mucic acid 5-O-gallate 1,4-lactone (9), chebulic acid (10), chebulanin (11), chebulagic acid (12), chebulinic acid (13), corilagin (14), ellagic acid (15), and isoquercitrin (16). Compounds 3-5 and 7-16 were detected earlier in P. emblica [3] whereas 6 was isolated for the first time from this species.…”

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confidence: 99%

“…Ellagotannins, gallotannins, mucic acid derivatives, nor-sesquiterpenoids, flavonoids, and essential oil occur in fruit of P. emblica according to reports of its chemical composition [3]. Gallates of galactaric (mucic) acid and its 1,4-lactone were isolated from P. emblica [4] and represent a unique group of highly hydrophilic phenolic compounds with antioxidant and antiproliferative activity [5].…”

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confidence: 99%

New Mucic Acid Gallates from Phyllanthus emblica

Оленников

Кащенко

Schwabl³

et al. 2015

Chem Nat Compd

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glucose, were identified by a phytochemical investigation of Phyllanthus emblica (Phyllanthaceae) fruit. Compounds 1 and 2 exhibited pronounced antioxidant activity. Keywords: Phyllanthus emblica, mucic acid 2,5-di-O-gallate, mucic acid 2,5-di-O-gallate 1,4-lactone, antioxidant activity. Phyllanthus emblica L. (Emblica officinalis Gaertn.; Indian gooseberry, amla) is a medicinal plant of the family Phyllanthaceae. Its fruit is widely used in traditional Asian medicine (China, India, Japan) as an anti-inflammatory and antipyretic agent [1]. A mixture of fruits from P. emblica, Terminalia chebula Retz., and T. bellirica (Gaertn.) Roxb. (Tibetan bras gsum; Indian, triphala) used individually or in combination with other plants is one of the most frequently used preparations in Tibetan and Ayurvedic medical practice [2]. Ellagotannins, gallotannins, mucic acid derivatives, nor-sesquiterpenoids, flavonoids, and essential oil occur in fruit of P. emblica according to reports of its chemical composition [3]. Gallates of galactaric (mucic) acid and its 1,4-lactone were isolated from P. emblica [4] and represent a unique group of highly hydrophilic phenolic compounds with antioxidant and antiproliferative activity [5]. We isolated 14 known compounds (3-16) and 2 new mucic acid derivatives (1 and 2) during a study of phenolic constituents from P. emblica fruit and studied the antioxidant activity of the new compounds.

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Biological Activities of Phenolics from the Fruits of Phyllanthus emblica L. (Euphorbiaceae)

Zhang

Miao

Zhu

et al. 2017

Chemistry & Biodiversity

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Seven phenolic compounds, 1 - 7, including a new organic acid gallate, mucic acid 1-ethyl 6-methyl ester 2-O-gallate (7), were isolated from the MeOH extract of the fruits of Phyllanthus emblica L. (Euphorbiaceae). The structures were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data. Upon evaluated for their antioxidant abilities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. The inhibitory activities against melanogenesis in B16 melanoma cells induced by α-MSH, as well as cytotoxic activities against four human cancer cell lines were also evaluated. All phenolic compounds, 1 - 7, exhibited potent antioxidant abilities (DPPH: IC 5.6 - 12.9 μm; ABTS: 0.87 - 8.43 μm Trolox/μm; FRAP: 1.01 - 5.79 μm Fe /μm, respectively). Besides, 5 - 7, also exhibited moderate inhibitory activities against melanogenesis (80.7 - 86.8% melanin content), even with no or low toxicity to the cells (93.5 - 101.6% cell viability) at a high concentration of 100 μm. Compounds 1 - 3 exhibited cytotoxic activity against one or more cell lines (IC 13.9 - 68.4%), and compound 1 with high tumor selectivity for A549 (SI 3.2).

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Chemical Constituents of the Plants from the Genus Phyllanthus

Cited by 27 publications

References 134 publications

Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis

Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis

New Mucic Acid Gallates from Phyllanthus emblica

Biological Activities of Phenolics from the Fruits of Phyllanthus emblica L. (Euphorbiaceae)

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