Chemical Constituents of Thymus seravschanicus and Their Biological Activity

Mamadalieva, Nilufar Z.; Ovidi, Elisa; Vinciguerra, Vittorio; Ashour, Mohamed L.; Azimova, Sh. S.; Tiezzi, Antonio

doi:10.1007/s10600-016-1643-2

Cited by 5 publications

(6 citation statements)

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“…According to the literature data [ 12 ], the antioxidant activity of the methanolic extract from T. seravschanicus from Uzbek flora was somewhat higher (IC 50 = 15.87 0.44 μg/mL) than that presented here. In contrast to the data presented in this paper, antioxidant activity of the hydroethanolic (70% v/v ) extract from T. marschallianus collected in North Eastern Moldavia was lower (IC 50 = 81.2 ± 1.3 µg/mL) [ 26 ].…”

Section: Discussionsupporting

confidence: 40%

“…Additionally, they detected methyl-rosmarinate and rosmarinic acid as the most important compounds for this species. What is more, Mamadalieva et al [ 12 ] performed studies on the phytochemical analysis of various extracts obtained from the aerial parts of T. seravschanicus from the Uzbek flora and identified two monoterpens (thymol, carvacrol) and three flavonoids (apigenin 7- O -glucoside, eriodictyol, naringenin) in the methanolic extract of this thyme species by the use of different chromatographic methods.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, there are only a few publications concerning the chemical composition and antimicrobial (antibacterial/antifungal) activity of Thymus marschallianus Willd. [ 8 , 9 , 10 , 11 ] and Thymus seravschanicus Klokov [ 12 , 13 ]. The performed studies included the analysis of various plant extracts, as well as essential oils.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan

et al. 2021

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The chemical composition of the hydroethanolic extracts (60% v/v) from the aerial parts of Thymus marschallianus Willd (TM) and Thymus seravschanicus Klokov (TS) from Southern Kazakhstan flora was analyzed together with their hexane fractions. Determination of antibacterial, antifungal and antioxidant activities of both extracts was also performed. RP-HPLC/PDA and HPLC/ESI-QTOF-MS showed that there were some differences between the composition of both extracts. The most characteristic components of TM were rosmarinic acid, protocatechuic acid, luteolin 7-O-glucoside, and apigenin 7-O-glucuronide, while protocatechuic acid, luteolin 7-O-glucoside, luteolin 7-O-glucuronide, and eriodictyol predominated in TS. The content of polyplenols was higher in TS than in TM. The GC-MS analysis of the volatile fraction of both examined extracts revealed the presence of thymol and carvacrol. Additionally, sesquiterpenoids, fatty acids, and their ethyl esters were found in TM, and fatty acid methyl esters in TS. The antioxidant activity of both extracts was similar. The antibacterial activity of TS extract was somewhat higher than TM, while antifungal activity was the same. TS extract was the most active against Helicobacter pylori ATCC 43504 with MIC (minimal inhibitory concentration) = 0.625 mg/mL, exerting a bactericidal effect. The obtained data provide novel information about the phytochemistry of both thyme species and suggest new potential application of TS as a source of bioactive compounds, especially with anti-H. pylori activity.

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Section: Discussionsupporting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan

et al. 2021

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“…In the present study, the phenolic contents of the ethanol extracts of N. cadmea were identified using the HPLC method and these are listed in Table . Some phenolic compounds determined in the present study, such as ferrulic, gallic, caffeic, vanilic, chlorogenic, ellagic acids, and rutin, were obtained from Lamiaceae plants in previous studies (Canadanovic‐Brunet et al., ; Mamadalieva et al., ; Roby et al., ). In addition, of these phenolic contents, ellagic acid is well known as an antioxidant (Mertens‐Talcott, Talcott, & Percival, ).…”

Section: Resultsmentioning

confidence: 82%

Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated from Nepeta cadmea: An Endemic Plant for Turkey

Kaska

Deniz

Çiçek

et al. 2018

Journal of Food Science

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The plants of the Nepeta genus have been extensively used as traditional herbal medicines. Nepeta cadmea Boiss., one of the species belonging to the Nepeta genus, is a species endemic to Turkey. In our study, we demonstrated the antioxidant capacities, total phenolic, flavonoid, tannin content, anthelmintic, and cytotoxic activities of various extracts of Nepeta cadmea. The present study could well supply valuable data for future investigations and further information on the potential use of this endemic plant for humans, in both dietary and pharmacological applications.

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“…The absorbance was measured at 570 nm. Experiments were performed in triplicate [ 40 , 51 , 52 , 53 ].…”

Section: Methodsmentioning

confidence: 99%

Discrimination of the Essential Oils Obtained from Four Apiaceae Species Using Multivariate Analysis Based on the Chemical Compositions and Their Biological Activity

Jamalova

Gad

Akramov

et al. 2021

Plants

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The chemical composition of the essential oils obtained from the aerial parts of four Apiaceae species, namely Elaeosticta allioides (EA), E. polycarpa (EP), Ferula clematidifolia (FC), and Hyalolaena intermedia (HI), were determined using gas chromatography. Altogether, 100 volatile metabolites representing 78.97, 81.03, 85.78, and 84.49% of the total components present in EA, EP, FC, and HI oils, respectively, were reported. allo-Ocimene (14.55%) was the major component in FC, followed by D-limonene (9.42%). However, in EA, germacrene D (16.09%) was present in a high amount, while heptanal (36.89%) was the predominant compound in HI. The gas chromatographic data were subjected to principal component analysis (PCA) to explore the correlations between these species. Fortunately, the PCA score plot could differentiate between the species and correlate Ferula to Elaeosticta species. Additionally, the antioxidant activity was evaluated in vitro using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and the ferric reducing power (FRAP) assays. In addition, the antimicrobial activity using the agar diffusion method was assessed, and the minimum inhibitory concentrations (MICs) were determined. Furthermore, the cell viability MTT assay was performed to evaluate the cytotoxicity of the essential oils against hepatic (HepG-2) and cervical (HeLa) cancer cell lines. In the DPPH assay, FC exhibited the maximum activity against all the antioxidant assays with IC50 values of 19.8 and 23.0 μg/mL for the DPPH and ABTS assays, respectively. Ferula showed superior antimicrobial and cytotoxic activities as well. Finally, a partial least square regression model was constructed to predict the antioxidant capacity by utilizing the metabolite profiling data. The model showed excellent predictive ability by applying the ABTS assay.

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Chemical Constituents of Thymus seravschanicus and Their Biological Activity

Cited by 5 publications

References 9 publications

Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan

Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov Growing Widely in Southern Kazakhstan

Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated from Nepeta cadmea: An Endemic Plant for Turkey

Discrimination of the Essential Oils Obtained from Four Apiaceae Species Using Multivariate Analysis Based on the Chemical Compositions and Their Biological Activity

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