Chemical Constituents of Zarrouk Medium Affect Growth, Pigments and Metabolites Productions of  Spirulina platensis

El-Monem, Ahmed M. Abd; Doman, Khalil M

doi:10.21608/ejbo.2019.6052.1245

Cited by 3 publications

(2 citation statements)

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“…Optimization of media and culture condition to obtain maximum yield in the tested species is a great demand of this investigation. The growth of cyanobacteria, in general, depends upon the availability of nitrogen and/or phosphate unless a large number of macro-nutrients and micronutrients are available for cyanobacterial growth (Larned 1998;Sun et al, 2018;Abd El-Monem et aL., 2021). The cited results clarify that L. sp.…”

Section: Discussionmentioning

confidence: 95%

In vitro Anticancer Potentialities of Three Egyptian Cyanobacterial Isolates against Breast Adenocarcinoma and Hepatocellular Carcinoma Cell Lines

Mofeed

Deyab

El-Bilawy³

2022

Egypt. J. Bot.

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C YANOBACTERIA represent a promising but not totally explored source of a wide array of secondary metabolites. They also represent a source for the discovery of compounds and drugs. In the present study, three cyanobacterial species, namely, Arthrospira platensis MH285264, Leptolyngbya boryana MH155317, and Leptolyngbya sp. MH285263 were tested for their anticancer capabilities against hepatocellular carcinoma (Hep-G2) and breast adenocarcinoma (MCF-7) cell lines. In order to obtain the highest biomasses of the tested organisms, they were optimized using 8 media recipes. The optimized organisms were tested for their biochemical constituents. The GC-MS of the tested cyanobacterial extracts revealed the presence of a number of bioactive metabolites which were previously known for their anticancer activity. The extracts of A. platensis and L. sp. showed a cytotoxic effect against the Hep-G2 cell line with IC 50 values of 14 and 15μg.mL −1 , respectively. The extracts of A. platensis and L. sp. showed more cytotoxic effects against the MCF-7 cell line with IC 50 values of 12.1 and 13.2µg.mL −1 , respectively. On the basis of the undiluted concentration used in this study (100μg.mL −1 ), the maximum inhibitory percentages compared with the control against the Hep-G2 and MCF-7 cell lines were 73.2% and 91.2%, respectively, by extracts of L. sp. and A. platensis. L. boryana exhibited a low and neglectable anticancer activity against both cell lines. The obtained promising results herald the existence of natural and safe alternatives with a high efficiency extracted from A. platensis and L. sp. for inclusion in the strategies of cancer treatment.

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Section: Discussionmentioning

confidence: 95%

In vitro Anticancer Potentialities of Three Egyptian Cyanobacterial Isolates against Breast Adenocarcinoma and Hepatocellular Carcinoma Cell Lines

Mofeed

Deyab

El-Bilawy³

2022

Egypt. J. Bot.

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“…Abou-Gabal et al (2018) studied the optimization of S. platensis using Kuhl's medium, but their study showed that Kuhl's medium was not the optimized growth medium for S. platensis cultivation. However, during previous studies, Zarrouk's medium was the most popular medium used for Spirulina cultivation (Abd El-Monem et al, 2019); it gave a lower growth rate than that was achieved from Kuhl's medium. Joshi et al (2018) reported that BG-11 growth medium was the best for Spirulina platensis, when they tested three different media i.e: BG-11, CHU, and Walne.…”

Section: Discussionmentioning

confidence: 99%

Growth Enhancement of Spirulina platensis through Optimization of Media and Nitrogen Sources

2020

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PIRULINA has drawn attention throughout the last decades. It is an essential source of valuable products, such as proteins, phycobilins, carotenoids, phenolics, and unsaturated fatty acids. These products had been used in medicine, pharmaceutical, and agriculture. In this study, the effect of different growth media on Spirulina platensis was studied after the cultivation at optimum growth conditions; continuous light intensity (60μmol photons m -2 s -1 ), temperature (25±3ºC), and pH (9.0 ± 0.2). The growth was estimated through 42 days by optical density (OD), cell counting (CC), and chlorophyll contents. The results showed that Kuhl's medium was the optimum for S. platensis with the highest results, i.e.: (OD), (CC) and Chlorophyll content increased 11.57 times, 19.55 times, and 22.66 times of the initial record, respectively. KNO 3 showed the best nitrogen source for S. platensis, where the different parameters of growth elevated to 3.56 times OD, 7.33 times CC, and 1.91 total chlorophyll more than their corresponding control.

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Synthesis of silver and copper nanoparticle using Spirulina platensis and evaluation of their anticancer activity

Doman

El-Monem

Morsi

2023

International Journal of Environmental Health Research

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Chemical Constituents of Zarrouk Medium Affect Growth, Pigments and Metabolites Productions of Spirulina platensis

Cited by 3 publications

References 0 publications

In vitro Anticancer Potentialities of Three Egyptian Cyanobacterial Isolates against Breast Adenocarcinoma and Hepatocellular Carcinoma Cell Lines

In vitro Anticancer Potentialities of Three Egyptian Cyanobacterial Isolates against Breast Adenocarcinoma and Hepatocellular Carcinoma Cell Lines

Growth Enhancement of Spirulina platensis through Optimization of Media and Nitrogen Sources

Synthesis of silver and copper nanoparticle using Spirulina platensis and evaluation of their anticancer activity

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