Chemical constituents, usage and pharmacological activity of Cassia alata

Fatmawati, Sri; Yuliana, Yuliana; Purnomo, Adi Setyo; Bakar, Mohd Fadzelly Abu

doi:10.1016/j.heliyon.2020.e04396

Cited by 65 publications

(51 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results of the study, it was found that the use of C. alata leaf extract could increase egg hatchability and survival of P. hypophthalmus (Table 1), where the higher the dose of extract used in the treatment will also increase the hatchability of fish eggs. Fatmawati et al [6] stated that C. alata leaf extract contains chemical compounds that can be used as antimicrobials. Furthermore, Makinde et al [12] said that the antibacterial and antifungal activity of the aqueous and methanolic extracts of C. alata leaves found that they had more antifungal properties than antibacterial.…”

Section: Resultsmentioning

confidence: 99%

“…One of the natural ingredients that has the potential to inhibit the growth of pathogens in fish is the use of Cassia alata leaves. This plant is known by different names in different countries, namely as Gelenggang (Malaysia), Ketepeng Badak or Ketepeng Cina (Indonesia) and bush ringworm (Australia) and has been used as as traditional medicine to treat various diseases [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect ofCassia alataL. leaf extract on egg hatching and survival ofPangasianodon hypophthalmuslarvae

2022

View full text Add to dashboard Cite

This study aims to determine the effect of using Cassia alata L. leaf extract on the prevention of fungus on fish eggs Pangasianodon hypophthalmus This research was conducted at the Blangpidie Fish Seed Center. Aceh Barat Daya from July to August 2020. Statistical analysis used a completely randomized design (CRD) method with 7 treatment levels and 3 replications. The treatments were conducted by soaking the fish eggs in the leaf extract for 20 minutes. Those treatments were A (control), B (2.5 ppm), C (5 ppm), D (7.5 ppm) E (10 ppm), F (12.5 ppm), and G (15 ppm). ANOVA test results showed that the addition of leaf extract C. alata had a significant (P <0.05) effect on hatchability and survival of P. hypophthalmus larvae. A concentration of 15 ppm is the best with a hatchability value of 85.33% and a concentration of 10 ppm is the most optimum for the survival value of P. hypophthalmus larvae, namely 92.99%.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect ofCassia alataL. leaf extract on egg hatching and survival ofPangasianodon hypophthalmuslarvae

2022

View full text Add to dashboard Cite

show abstract

“…Phytochemical screening for secondary metabolites in the hydro-ethanolic extract of SP leaves was performed using standard phytochemical methods reported in the literature. 10 11 Results suggested that alkaloid, saponin, tannin, cardiac glycoside, flavonoid, anthraquinone, and phenol were present in the SP extract, while steroids were absent. Tannins, flavonoids, and phenols are potent antioxidants, and antioxidants have been implicated in wound healings by improving vascularization and reducing lipid peroxidation which in turn prevents necrosis of cells and promotes cell proliferation.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of alkaloids, saponins, tannins, steroids, cardiac-active glycoside, flavonoids, anthraquinones, and phenols in the extract was assessed respectively as the following according to the reported studies 10,11 :…”

Section: Phytochemical Screening Of Plant Extractmentioning

confidence: 99%

Senna podocarpa Emulgel: A Herbal Alternative for Chemical Burn Wound Treatment

Isaac

Daburi

Ifeanyi

et al. 2022

Pharmaceutical Fronts

View full text Add to dashboard Cite

Senna podocarpa (SP) leaves are used in folk medicines for treatment of burns and wounds as poultices on wound surface. However, to the best of our knowledge, the wound healing ability of this plant has not been scientifically evaluated. This work aimed to determine the wound healing potential of the crude extract of SP leaves, and to evaluate the benefit of its preparation as an emulgel. In this study, the formulations of 2.5% of SP emulgel (F1) and 7.5% of SP emulgel (F2) were prepared by mixing the emulsion phase with the gel phase in a ratio of 1:1, and then physical appearance, globule size, pH, viscosity, swelling, water activity, extrudability, occlusion, spreadability, stability, and wound healing ability were determined. Phytochemical screening showed the presence of alkaloids, saponins, tannins, cardiac glycosides, flavonoids, anthraquinones, and phenols within the hydro-ethanolic extract of SP leaves, and high flavonoid content is believed to be responsible for its healing attributes. Our formulations showed acceptable physical properties. Hematoxylin-eosin and Verhoeff–Van Gieson stain showed that F2 could induce the accumulation of fibroblasts, fibrocytes, inflammatory cells, gland cells, epidermal cells, adipocytes, and collagen in the process of wound healing in mice injured with hydrochloric acid. Encouragingly, the percent of wound contractions in mice treated with F1, F2, and SP leaf poultice were 64, 87, and 50, respectively, suggesting the superior healing properties exhibited by SP emulgel over SP leaf poultice, and this may due to the occlusive property of emulgels. In conclusion, F2 of crude extract of SP leaves has better pharmacological effects on burn and wound healing, and may represent a preferred choice to treat burn wounds in the future.

show abstract

“…The antifungal activity of P. thonningii against C. albicans was studied previously with the ethanolic extract showing significant activity in inhibiting the growth of cells and an MIC of 0.312 μ g/mL. Other studies [ 38 , 39 ] have found that the ethanol leaf extract of Cassia alata caused a dose-dependent effect on Candida albicans , Microsporum canis, and Trichophyton mentagrophyte . The phytochemical and antifungal analysis of the ethanolic extract of P. thonningii showed the presence of flavonoids which were effective in inhibiting the growth of C. albicans , Colletotrichum musae, and Sclerotium rolfsii [ 40 – 42 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Antimicrobial Effect of the Extracts of the Pods of Piliostigma thonningii (Schumach.) Milne-Redh. (Fabaceae)

Makosa

Sithole

Mukanganyama

2021

Advances in Pharmacological and Pharmaceutical Sciences

View full text Add to dashboard Cite

Plants have been used traditionally by people in treating and the management of diseases since time immemorial. Traditional medicines including the herbal medicines are used for primary healthcare in some domains in almost every country. Approximately 80% of the population in developing coutries depend on plants as their source of medicine for combating diseases. New and effective antimicrobial agents that have novel mechanism of actions are required. Piliostigma thonningii (Schumach.) Milne-Redh. is a species of flowering plants in the legume family, Fabaceae. Different parts of the P. thonningii plants such as the roots, leaves, seeds, and fruits have been used in treating wounds, heart pain, and gingivitis and as cough remedy. This study focused on determining the antimicrobial properties found in the pods of P. thonningii. The sample was prepared by grinding the dried pods into a fine powder. Successive extraction and extraction with 1 : 1 DCM: methanol was used. The antimicrobial assay was carried out using the broth microdilution and MTT assay. The microorganism used for the tests was Pseudomonas aeruginosa, Candida krusei and Mycobacterium smegmatis. The most potent extract was then used to determine its effect on microbial cell membrane integrity. The results showed that methanol extract had the highest percentage yield of 5%. The extract with the highest antimicrobial effects was ethanol extract with the 100 μg/mL concentration inhibiting the growth of cells to 26%, 87%, and 90% for P. aeruginosa, M. smegmatis, and C. krusei, respectively. The ethanol extracts caused significant leakage of proteins in these microorganisms. In conclusion, the pods of P. thonningii contain phytochemicals with antimicrobial properties. The pods of the plant can be a source of phytochemicals that can serve as sources of lead compounds with antimicrobial effects. One of the mechanisms of action of these phytochemicals is via membrane-damaging effects on microbes.

show abstract

Chemical constituents, usage and pharmacological activity of Cassia alata

Cited by 65 publications

References 57 publications

The effect ofCassia alataL. leaf extract on egg hatching and survival ofPangasianodon hypophthalmuslarvae

The effect ofCassia alataL. leaf extract on egg hatching and survival ofPangasianodon hypophthalmuslarvae

Senna podocarpa Emulgel: A Herbal Alternative for Chemical Burn Wound Treatment

Evaluation of the Antimicrobial Effect of the Extracts of the Pods of Piliostigma thonningii (Schumach.) Milne-Redh. (Fabaceae)

Contact Info

Product

Resources

About