Chemical disinfection in healthcare settings: critical aspects for the development of global strategies

Exner, Martin; Bhattacharya, Sanjay; Gebel, Jürgen; Goroncy‐Bermes, Peter; Hartemann, Philippe; Heeg, Peter; Ilschner, Carola; Krämer, Axel; Ling, Moi Lin; Merkens, Wolfgang; Oltmanns, Peter; Pitten, Frank; Rotter, M.; Schmithausen, Ricarda Maria; Sonntag, Hans‐Günther; Steinhauer, Kathrin; Trautmann, Matthias

doi:10.3205/dgkh000371

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…These results also show that contact time, followed by removal of blood stains of spray and foam in the instruments, resulted in time measurements of 2 minutes and fi ve that were similar. This is consistent with studies of the reprocessing procedure for medical devices must be available as a standard operating procedure and describe the following steps: pre-cleaning (if applicable), cleaning (possibly two times), disinfection, drying, functional testing, packaging, sterilization (if applicable), labeling, release, transport, storage of sterile supplies [4,5].…”

Section: Discussionsupporting

confidence: 72%

Comparative Double-Blind Study of Efficacy of Pre-Cleaners for Surgical Instruments and Medical Devices in the Central Sterile Services Department

Jindarat¹,

Chanchai²

2022

J Biomed Res Environ Sci

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The Central Sterile Supply Department (CSSD) is one of the hospital's critical support services. It is a place to receive medical equipment blood-stained from the other departments to be cleaned. It is responsible for cleaning, receiving, storing, sterilizing, and returning medical equipment to everyone and delivered to different departments within the hospital. Nowadays, various cleaning and dissolving blood stains are used to clean and remove blood stains. This research aimed to compare the efficacy of pre-cleaning spray and pre-cleaning spray foam cleaners for blood-contaminated surgical instruments and medical devices in the Central Sterile Services Department. The pre-cleaning spray was significantly higher than the pre-cleaning spray foam (p ≤ .005). A significant difference in the 2-minute pre-cleaning spray was observed by using cleaning indicators. The pre-cleaning spray foam started dissolving blood after 5 minutes. Therefore, from the study, using the pre-cleaning spray for dissolving blood stains and pre-cleaning has a more practical effect than pre-cleaning foam.

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Section: Discussionsupporting

confidence: 72%

Comparative Double-Blind Study of Efficacy of Pre-Cleaners for Surgical Instruments and Medical Devices in the Central Sterile Services Department

Jindarat¹,

Chanchai²

2022

J Biomed Res Environ Sci

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“…This could be interesting for objects with frequent, brief, or indirect contacts with biological tissues. The silver-loaded sol–gel could be a supplementary tool in the complex strategies for disinfection in healthcare …”

Section: Discussionmentioning

confidence: 99%

“…The silver-loaded sol–gel could be a supplementary tool in the complex strategies for disinfection in healthcare. 28 …”

Section: Discussionmentioning

confidence: 99%

A Kinetic Approach to Synergize Bactericidal Efficacy and Biocompatibility in Silver-Based Sol–Gel Coatings

Zwingelstein,

Figarol,

Luzet

et al. 2024

ACS Omega

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Silver ions are antimicrobial agents with powerful action against bacteria. Applications in surface treatments, as Ag+-functionalized sol–gel coatings, are expected in the biomedical field to prevent contaminations and infections. The potential cytotoxicity of Ag+ cations toward human cells is well known though. However, few studies consider both the bactericidal activity and the biocompatibility of the Ag+-functionalized sol–gels. Here, we demonstrate that the cytotoxicity of Ag+ cations is circumvented, thanks to the ability of Ag+ cations to kill Escherichia coli (E. coli) much faster than normal human dermal fibroblasts (NHDFs). This phenomenon was investigated in the case of two silver nitrate-loaded sol–gel coatings: one with 0.5 w/w% Ag+ cations and the second with 2.5 w/w%. The maximal amount of released Ag+ ions over time (0.25 mg/L) was ten times lower than the minimal inhibition (MIC) and minimal bactericidal (MBC) concentrations (respectively, 2.5 and 16 mg/L) for E. coli and twice lower to the minimal cytotoxic concentration (0.5 mg/L) observed in NHDFs. E. coli were killed 8–18 times, respectively, faster than NHDFs by silver-loaded sol–gel coatings. This original approach, based on the kinetic control of the biological activity of Ag+ cations instead of a concentration effect, ensures the bactericidal protection while maintaining the biocompatibility of the Ag+ cation-functionalized sol–gels. This opens promising applications of silver-loaded sol–gel coatings for biomedical tools in short-term or indirect contacts with the skin.

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“…54 Biocides like chlorine, iodine, alcohols, etc., commonly found in disinfectants, are used to control infections in critical healthcare settings and are now being marketed for home use. 55 Scientific studies have shown that the use and improper use of products containing biocides can potentially lead to antibiotic resistance in bacteria. Additionally, bacteria that are tolerant to biocides have been found to also possess resistance to antibiotics.…”

Section: Dovepressmentioning

confidence: 99%

Potential Causes of Spread of Antimicrobial Resistance and Preventive Measures in One Health Perspective-A Review

Endale,

Mathewos,

Abdeta

2023

IDR

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Antimicrobial resistance, referring to microorganisms’ capability to subsist and proliferate even when there are antimicrobials is a foremost threat to public health globally. The appearance of antimicrobial resistance can be ascribed to anthropological, animal, and environmental factors. Human-related causes include antimicrobial overuse and misuse in medicine, antibiotic-containing cosmetics and biocides utilization, and inadequate sanitation and hygiene in public settings. Prophylactic and therapeutic antimicrobial misuse and overuse, using antimicrobials as feed additives, microbes resistant to antibiotics and resistance genes in animal excreta, and antimicrobial residue found in animal-origin food and excreta are animals related contributive factors for the antibiotic resistance emergence and spread. Environmental factors including naturally existing resistance genes, improper disposal of unused antimicrobials, contamination from waste in public settings, animal farms, and pharmaceutical industries, and the use of agricultural and sanitation chemicals facilitatet its emergence and spread. Wildlife has a plausible role in the antimicrobial resistance spread. Adopting a one-health approach involving using antimicrobials properly in animals and humans, improving sanitation in public spaces and farms, and implementing coordinated governmental regulations is crucial for combating antimicrobial resistance. Collaborative and cooperative involvement of stakeholders in public, veterinary and ecological health sectors is foremost to circumvent the problem effectively.

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Chemical disinfection in healthcare settings: critical aspects for the development of global strategies

Cited by 5 publications

References 32 publications

Comparative Double-Blind Study of Efficacy of Pre-Cleaners for Surgical Instruments and Medical Devices in the Central Sterile Services Department

Comparative Double-Blind Study of Efficacy of Pre-Cleaners for Surgical Instruments and Medical Devices in the Central Sterile Services Department

A Kinetic Approach to Synergize Bactericidal Efficacy and Biocompatibility in Silver-Based Sol–Gel Coatings

Potential Causes of Spread of Antimicrobial Resistance and Preventive Measures in One Health Perspective-A Review

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