Chemical durability of Y2O3‐Al2O3‐SiO2 glasses for the in vivo delivery of beta radiation

Erbe, Erik M.; Day, Delbert E.

doi:10.1002/jbm.820271010

Cited by 98 publications

(51 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several compositions of YAS glass were tested experimentally, and that with the highest durability, commonly used in in situ radiotherapy, had 17.1 mol% Y 2 O 3 , 18.9 mol% Al 2 O 3 , and 64.0 mol% SiO 2 (this composition is hereafter termed YAS17). [4] In order to optimize this kind of cancer treatment, it is critical to understand how yttrium is bound into the glass network and the factors which control its dissolution from the bulk glass into a surrounding fluid; however, the atomistic properties of YAS glass, particularly those relating to the local yttrium structure, are not well understood. There is only a We present Car-Parrinello molecular dynamics (CPMD) simulations of yttrium alumino-silicate (YAS) glass.…”

mentioning

confidence: 99%

Short‐Range Structure of Yttrium Alumino‐Silicate Glass for Cancer Radiotherapy: Car–Parrinello Molecular Dynamics Simulations

Christie

Tilocca

2010

Adv Eng Mater

View full text Add to dashboard Cite

Yttrium alumino-silicate (YAS) glass has an application in in situ cancer radiotherapy. [1] Conventional radiotherapy irradiates a tumor from a radiation source external to the body, which can cause substantial damage to the surrounding healthy tissue. On the other hand, internal, or in situ, radiotherapy implants a radiation source into the tumor or surrounding blood vessels, from where it can irradiate the tumor directly. This approach reduces the unnecessary damage to healthy tissues and the corresponding side effects of conventional radiotherapy. One method currently used for in situ radiotherapy is to inject a solution of YAS glass microspheres, in which the 90 Y isotope has been excited to a radioactive state, into the blood vessels supplying the tumor.The microspheres then reach and settle in the target tumor, which is hit by the localized radiation released from the yttrium source bound within the glass. The in situ method has been successful in treating deeply seated tumors associated with liver and kidney cancer, which are difficult to treat with conventional radiotherapy. [2,3] The key property of the glass for the success of this application is its chemical durability, defined as the inverse of the release rate of yttrium in the physiological environment. The glass should release as little radioactive 90 Y into the bloodstream as possible, because any yttrium so released would be transported to other healthy organs, which would be exposed to harmful doses of radiation. The half-life of 90 Y is 2.7 days, so the microspheres need only to be durable over a timescale of a few weeks. Several compositions of YAS glass were tested experimentally, and that with the highest durability, commonly used in in situ radiotherapy, had 17.1 mol% Y 2 O 3 , 18.9 mol% Al 2 O 3 , and 64.0 mol% SiO 2 (this composition is hereafter termed YAS17). [4] In order to optimize this kind of cancer treatment, it is critical to understand how yttrium is bound into the glass network and the factors which control its dissolution from the bulk glass into a surrounding fluid; however, the atomistic properties of YAS glass, particularly those relating to the local yttrium structure, are not well understood. There is only a We present Car-Parrinello molecular dynamics (CPMD) simulations of yttrium alumino-silicate (YAS) glass. Alumino-silicate glass microspheres are used as vectors of yttrium radioisotopes in cancer radiotherapy; understanding in detail how yttrium is bound within the glass network is important to control the unwanted release of radioactive yttrium in the bloodstream. Our simulations, focused on a specific composition relevant to practical applications, show that silicon and aluminum form a disordered glass network, where Si is mainly four-coordinated, whereas, Al is mainly four-and five-coordinated. Yttrium cations have a network-modifying role, disrupting the alumino-silicate network by breaking Si(Al)ÀO bonds and coordinating the resulting non-bridging oxygens (NBO). The local environment of yttrium in the glass turns ...

show abstract

mentioning

confidence: 99%

Short‐Range Structure of Yttrium Alumino‐Silicate Glass for Cancer Radiotherapy: Car–Parrinello Molecular Dynamics Simulations

Christie

Tilocca

2010

Adv Eng Mater

View full text Add to dashboard Cite

show abstract

“…Besides the bone-bonding properties, in many biomedical applications one is also interested in the rate of leaching of specific cations from the glass. For instance, active ions such as cerium, gallium, zinc, strontium and cobalt are incorporated in bioactive glasses with the purpose of delivering and gradually releasing them to a target tissue [42,[71][72][73][74][75][76][77][78]; also, yttrium and other ions are employed as radiation sources in in-situ radiotherapy, and silicate glasses are amongst the most common carriers for these radioisotopes [79,80]. In the latter applications, it is of vital importance that the radioactive species are confined within the glass carrier during the treatment, because their release in the bloodstream would have adverse effects [81].…”

Section: Structural Propertiesmentioning

confidence: 99%

Rationalizing the Biodegradation of Glasses for Biomedical Applications Through Classical and Ab-initio Simulations

Tilocca

2015

Molecular Dynamics Simulations of Disordered Materials

View full text Add to dashboard Cite

The gradual dissolution of a glass in a living host determines the rate at which processes leading to tissue regeneration can occur, which is of crucial importance for the success of biomedical implants and scaffolds for tissue engineering based on the glass. In-situ radiotherapy applications are also affected-in an opposite way-by the rate at which the glass vector used to deliver radioisotopes will degrade in the bloodstream. This chapter illustrates how a combination of classical and ab-initio simulations techniques, mainly centred on Molecular Dynamics, can shed new light into structural and dynamical features that control the biodegradation of these materials. IntroductionA biomaterial is a material able to elicit a favourable reaction from the human body, leading for instance to the repair of damaged or diseased tissues, including but not limited to bones and soft tissues [1,2]. The high costs and risks associated to autoand allografts for bone replacement have led to large advances in the development and clinical application of synthetic substitutes. For instance, first-generation bioinert materials are metals, alloys and ceramics such as zirconia and alumina, whose application as bone replacement relies on a tight mechanical fit in the implant site. A superior performance can be achieved by second-generation bioactive materials, able to form chemical bonds with the existing issues, which results in better biocompatibility, integration and stability of the implant [1]. The first biomaterials with these desirable bone-bonding properties were the soda-lime phosphosilicate compositions (such as the 45S5 Bioglass ) introduced by Hench in the 70s [3]. Even though several other bioactive materials (such as crystalline calcium phosphates and silicates [4]) able to bond to tissues have been identified thereafter, their performances have A.Tilocca (B)

show abstract

“…In 1987 Hyatt and Day [4] and Erbe and Day [5] proved for the first time that it was possible to use 17Y 2 O 3 -19Al 2 O 3 -64 SiO 2 (mol%) 20 -30 mcm diameter glass microspheres for in situ irradiation of cancer. In this glass Yttrium-89 ( 89 Y) is nonradioactive isotope, which is found in nature at 100%, but neutron irradiation results in activation of 89 Y, which results in creation of β-irradiating 90 Y, half-life of which equals to 64.1 hr.…”

Section: Ceramic Microspheres For Cancer Radiotherapy Y 2 O 3 -Al 2 Omentioning

confidence: 99%

Controlled Local Hyperthermia and Magnetic Hyperthermia of Surface (Skin) Cancer Diseases

Kovziridze

Khorava²,

Mitskevich³

2013

JCT

View full text Add to dashboard Cite

Average size of hematite and magnetite micro and nanopowders and polydispersity index, zeta potential and distribution of particles were studied. Analysis showed that average size of the obtained particles for magnetite is 740.9 nm, for hematite particles 30 -35 nm. Alternate current feed source was created for hyperthermia. Proceeding from the requirements of the objectives, the U type MnZn material magneto conductors were selected, in which 10.0 and 8.0 mm width gaps were cut and glass test tubes with magnetite or hematite suspensions were placed in them. Series of experiments at various field intensity and frequencies showed that for efficient magnetic hyperthermia therapy more powerful device was needed with frequency of up to 10 Mega Hertz to achieve the temperature 43˚C -45˚C necessary for full activation of Neel and Brown mechanisms in particles. At the next stage, on the basis of experimental material the anticancer mono-therapeutic effect of hyperthermia and its adjuvant action in poly chemotherapeutic treatment was presented by the use of a device created by us "Lezi". As a result of the experiment it was shown that in all animals (outbred albino mice, 3 months old) inhibition of cancer growth was fixed and intratumoral necrosis was developed, while after 7 and 10 sessions tumors were ulcerated, which refers to positive effect of the experiment (Conclusion of Pathologicanatomical Laboratory "PATGEO", Tbilisi, Georgia ).

show abstract

Chemical durability of Y₂O₃‐Al₂O₃‐SiO₂ glasses for the in vivo delivery of beta radiation

Cited by 98 publications

References 14 publications

Short‐Range Structure of Yttrium Alumino‐Silicate Glass for Cancer Radiotherapy: Car–Parrinello Molecular Dynamics Simulations

Short‐Range Structure of Yttrium Alumino‐Silicate Glass for Cancer Radiotherapy: Car–Parrinello Molecular Dynamics Simulations

Rationalizing the Biodegradation of Glasses for Biomedical Applications Through Classical and Ab-initio Simulations

Controlled Local Hyperthermia and Magnetic Hyperthermia of Surface (Skin) Cancer Diseases

Contact Info

Product

Resources

About