Chemical ecology in the Southern Ocean

Angulo‐Preckler, Carlos; Castro-Fernández, Paula De; Martín–Martín, Rafael P.; Figuerola, Blanca; Ávila, Conxita

doi:10.1017/9781108683319.015

Cited by 3 publications

(25 citation statements)

References 1,386 publications

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“…The spectroscopic data of the re compound did not match with any of the known terpenes and was characterized aplysulphurane derivative especially abundant in the specimens from Deception which therefore we named deceptionin (Rt = 20.3) (7, Figure 2 and Supple Materials Figures S7-S15). (7) Deceptionin (7) gave a molecular ion adduct [M + Na] + in HRESIMS at m/z 415.24591 which was consistent with the molecular formula C 23 H 36 O 5 (theor. 415.24550) requiring six degrees of unsaturation (Figure S8).…”

Section: Major Diterpenes In D Antarctica Populations From Two Differ...mentioning

confidence: 71%

“…Benthic invertebrates in general, and sponges in particular, are a rich source of bioactive molecules that could serve as base for developing new drugs or have an industrial application. The samples of D. antarctica contained seven major diterpenes, one of which was characterized as a new aplysulphurane derivative, deceptionin (7). Further antimicrobial assays using different pathogenic strains, as well as cytotoxicity and other bioactivity tests should be performed to search for the potential bioactivity of the compound.…”

Section: Discussionmentioning

confidence: 99%

“…In these communities, sponges provide habitat and food for many other species, being a fundamental element of these benthic ecosystems [ 2 , 3 , 4 , 5 ]. Many of the species living in these communities use chemical communication and therefore are rich in natural products [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. As with other organisms, sponges produce biologically active natural compounds to avoid predation, competition, pathogenic infections, or fouling, among other things [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Drugs 2023, 21, 499 2 of 20 benthic ecosystems [2][3][4][5]. Many of the species living in these communities use chemical communication and therefore are rich in natural products [6][7][8][9][10][11][12]. As with other organisms, sponges produce biologically active natural compounds to avoid predation, competition, pathogenic infections, or fouling, among other things [13,14].…”

Section: Introductionmentioning

confidence: 99%

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A Chemo-Ecological Investigation of Dendrilla antarctica Topsent, 1905: Identification of Deceptionin and the Effects of Heat Stress and Predation Pressure on Its Terpene Profiles

De Castro-Fernández,

Angulo-Preckler,

García-Aljaro

et al. 2023

Marine Drugs

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Marine sponges usually host a wide array of secondary metabolites that play crucial roles in their biological interactions. The factors that influence the intraspecific variability in the metabolic profile of organisms, their production or ecological function remain generally unknown. Understanding this may help predict changes in biological relationships due to environmental variations as a consequence of climate change. The sponge Dendrilla antarctica is common in shallow rocky bottoms of the Antarctic Peninsula and is known to produce diterpenes that are supposed to have defensive roles. Here we used GC-MS to determine the major diterpenes in two populations of D. antarctica from two islands, Livingston and Deception Island (South Shetland Islands). To assess the potential effect of heat stress, we exposed the sponge in aquaria to a control temperature (similar to local), heat stress (five degrees higher) and extreme heat stress (ten degrees higher). To test for defence induction by predation pressure, we exposed the sponges to the sea star Odontaster validus and the amphipod Cheirimedon femoratus. Seven major diterpenes were isolated and identified from the samples. While six of them were already reported in the literature, we identified one new aplysulphurane derivative that was more abundant in the samples from Deception Island, so we named it deceptionin (7). The samples were separated in the PCA space according to the island of collection, with 9,11-dihydrogracilin A (1) being more abundant in the samples from Livingston, and deceptionin (7) in the samples from Deception. We found a slight effect of heat stress on the diterpene profiles of D. antarctica, with tetrahydroaplysulphurin-1 (6) and the gracilane norditerpene 2 being more abundant in the group exposed to heat stress. Predation pressure did not seem to influence the metabolite production. Further research on the bioactivity of D. antarctica secondary metabolites, and their responses to environmental changes will help better understand the functioning and fate of the Antarctic benthos.

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Section: Major Diterpenes In D Antarctica Populations From Two Differ...mentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Chemo-Ecological Investigation of Dendrilla antarctica Topsent, 1905: Identification of Deceptionin and the Effects of Heat Stress and Predation Pressure on Its Terpene Profiles

De Castro-Fernández,

Angulo-Preckler,

García-Aljaro

et al. 2023

Marine Drugs

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“…Marine natural products (MNPs) are a still understudied source of potentially bioactive compounds [ 25 , 26 ]. Among them, Antarctic MNPs are even more unknown regarding their biological function and their putative pharmacological role as drugs, mainly due to the difficulties in their collection, identification, and further laboratory synthesis [ 27 , 28 , 29 , 30 , 31 ]. Meridianins are a family of indole alkaloids consisting of an indole framework linked to an aminopyrimidine ring, described from marine benthic organisms from Antarctica, particularly from Aplidium ascidians [ 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Meridianins Inhibit GSK3β In Vivo and Improve Behavioral Alterations Induced by Chronic Stress

et al. 2022

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Major depression disorder (MDD) is a severe mental alteration with a multifactorial origin, and chronic stress is one of the most relevant environmental risk factors associated with MDD. Although there exist some therapeutical options, 30% of patients are still resistant to any type of treatment. GSK3β inhibitors are considered very promising therapeutic tools to counteract stress-related affectations. However, they are often associated with excessive off-target effects and undesired secondary alterations. Meridianins are alkaloids with an indole framework linked to an aminopyrimidine ring from Antarctic marine ascidians. Meridianins could overcome several of the aforementioned limitations since we previously demonstrated that they can inhibit GSK3β activity without the associated neurotoxic or off-target effects in rodents. Here, we show that meridianins delivered into the lateral ventricle inhibited GSK3β in several brain regions involved with stress-related symptoms. We also observed changes in major signaling pathways in the prefrontal cortex (Akt and PKA) and hippocampus (PKC and GluR1). Moreover, meridianins increased synaptic activity, specifically in the CA1 but not in the CA3 or other hippocampal subfields. Finally, we chronically treated the mice subjected to an unpredictable mild chronic stress (CUMS) paradigm with meridianins. Our results showed improvements produced by meridianins in behavioral alterations provoked by CUMS. In conclusion, meridianins could be of therapeutic interest to patients with stress-related disorders such as MDD.

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Would Antarctic Marine Benthos Survive Alien Species Invasions? What Chemical Ecology May Tell Us

et al. 2022

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Many Antarctic marine benthic macroinvertebrates are chemically protected against predation by marine natural products of different types. Antarctic potential predators mostly include sea stars (macropredators) and amphipod crustaceans (micropredators) living in the same areas (sympatric). Recently, alien species (allopatric) have been reported to reach the Antarctic coasts, while deep-water crabs are suggested to be more often present in shallower waters. We decided to investigate the effect of the chemical defenses of 29 representative Antarctic marine benthic macroinvertebrates from seven different phyla against predation by using non-native allopatric generalist predators as a proxy for potential alien species. The Antarctic species tested included 14 Porifera, two Cnidaria, two Annelida, one Nemertea, two Bryozooa, three Echinodermata, and five Chordata (Tunicata). Most of these Antarctic marine benthic macroinvertebrates were chemically protected against an allopatric generalist amphipod but not against an allopatric generalist crab from temperate waters. Therefore, both a possible recolonization of large crabs from deep waters or an invasion of non-native generalist crab species could potentially alter the fundamental nature of these communities forever since chemical defenses would not be effective against them. This, together with the increasing temperatures that elevate the probability of alien species surviving, is a huge threat to Antarctic marine benthos.

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Chemical ecology in the Southern Ocean

Cited by 3 publications

References 1,386 publications

A Chemo-Ecological Investigation of Dendrilla antarctica Topsent, 1905: Identification of Deceptionin and the Effects of Heat Stress and Predation Pressure on Its Terpene Profiles

A Chemo-Ecological Investigation of Dendrilla antarctica Topsent, 1905: Identification of Deceptionin and the Effects of Heat Stress and Predation Pressure on Its Terpene Profiles

Meridianins Inhibit GSK3β In Vivo and Improve Behavioral Alterations Induced by Chronic Stress

Would Antarctic Marine Benthos Survive Alien Species Invasions? What Chemical Ecology May Tell Us

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