Chemical elements and preeclampsia - An overview of current problems, challenges and significance of recent research

Gajewska, Katarzyna; Błażewicz, Anna; Laskowska, Marzena; Niziński, Przemysław; Dymara-Konopka, Weronika; Komsta, Łukasz

doi:10.1016/j.jtemb.2020.126468

Cited by 14 publications

(20 citation statements)

References 82 publications

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“…PE is called the disease of theories, as its cause still uncertain. The cardinal manifestation of PE is hypertension, and in complicated cases, there are manifestation of multiple organ dysfunction [5] .…”

Section: Introductionmentioning

confidence: 99%

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Selected Trace Elements in Egyptian Females with Preeclampsia

Emam¹,

Attia

2020

International Journal of Medical Arts

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Background: Evidence exist indicating that, trace elements could play a role in preeclampsia [PE]. However, controversy exist regarding the role of the value of trace elements supplementation on the pregnancy outcome. Aim of the work:To estimate serum levels of some trace elements [selenium, calcium, magnesium, iron and zinc] in females developed preeclampsia and compare them to healthy pregnant females and correlate it with pregnancy outcome.Patients and Methods: 140 females were included in each group [preeclampsia and controls]. All had been assessed clinically, and by laboratory and ultrasound investigations. In addition, serum levels of selenium, calcium, magnesium, iron and zinc, had been determined and correlated with pregnancy outcome.Results: There was statistically significant increase of all trace elements in preeclamptic when compared to control groups. There was significant increase of females with deficient zinc, iron, calcium, magnesium and selenium in PE when compared to control group [83.6%, 19.3%, 30.7%, 27.9% and 40.0% vs 22.9%, 5.7%, 4.3%, 2.9% and 5.0% respectively]. The odds ratio where higher for zinc, followed by selenium, magnesium, calcium and finally iron deficiency. In addition, zinc, iron, calcium, magnesium and selenium were inversely and significantly correlated with systolic blood pressure. Preeclampsia was associated with worse maternal-fetal outcome when compared to controls. Conclusion:Lower levels of studied trace elements are associated with development of preeclampsia and we assume that, supplementation by such elements could reduce the risk of preeclampsia. However, this assumption needs to confirmed in future trials.

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Section: Introductionmentioning

confidence: 99%

“…Many authors explained the role of trace elements by as an essential elements in the normal functions of the cell, as structural component, enzyme cofactors and redox sensors [5] . However, controversy exist regarding role of trace elements in PE.…”

Section: Introductionmentioning

confidence: 99%

Selected Trace Elements in Egyptian Females with Preeclampsia

Emam¹,

Attia

2020

International Journal of Medical Arts

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“…In order to gain insights into the role of inorganics in healthy and preeclamptic placentae, bulk multi-element analysis was performed on placental tissue. Elemental concentrations in blood and urine may fluctuate during pregnancy due to physiological and metabolic changes ( 36 ). Thus, for a more robust survey, major elements ( Figure 1 ) and trace elements ( Figure 2 ) were analyzed directly in the placental tissue after postpartum by elemental analysis using ICP-MS ( Supplementary Tables 1 , 2 ).…”

Section: Resultsmentioning

confidence: 99%

The Role of Inorganics in Preeclampsia Assessed by Multiscale Multimodal Characterization of Placentae

et al. 2022

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Preeclampsia is one of the most dangerous diseases in pregnancy. Because of the hypertensive nature of preeclampsia, placental calcifications are believed to be a predictor for its occurrence, analogous to their role in cardiovascular diseases. However, the prevalence and the relevance of calcifications for the clinical outcome with respect to preeclampsia remains controversial. In addition, the role of other inorganic components present in the placental tissue in the development of preeclampsia has rarely been investigated. In this work, we therefore characterized inorganic constituents in placental tissue in groups of both normotensive and preeclamptic patients (N = 20 each) using a multi-scale and multi-modal approach. Examinations included elemental analysis (metallomics), sonography, computed tomography (CT), histology, scanning electron microscopy, X-ray fluorescence and energy dispersive X-ray spectroscopy. Our data show that tissue contents of several heavy metals (Al, Cd, Ni, Co, Mn, Pb, and As) were elevated whereas the Rb content was decreased in preeclamptic compared to normotensive placentae. However, the median mineral content (Ca, P, Mg, Na, K) was remarkably comparable between the two groups and CT showed lower calcified volumes and fewer crystalline deposits in preeclamptic placentae. Electron microscopy investigations revealed four distinct types of calcifications, all predominantly composed of calcium, phosphorus and oxygen with variable contents of magnesium in tissues of both maternal and fetal origin in both preeclamptic and normotensive placentae. In conclusion our study suggests that heavy metals, combined with other factors, can be associated with the development of preeclampsia, however, with no obvious correlation between calcifications and preeclampsia.

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“…Lead concentration in whole blood is the best biomarker of lead exposure, with the best ability to discriminate between individuals with different mean concentrations [36]. Among all the works included in an extensive review of chemical elements in PE [37], only 4% of papers considered environmental exposure. Obviously, preventing additional lead exposure can help prevent adverse health outcomes in children [38].…”

Section: Discussionmentioning

confidence: 99%

Lead Levels in Non-Occupationally Exposed Women with Preeclampsia

et al. 2021

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There are many controversies regarding the relationship between lead exposure andcomplications in pregnancy. Preeclampsia (PE) is a maternal hypertensive disorder which is one of the main causes of maternal and foetal mortality. The aim of our study was to assess blood lead level (BLL) in Polish women with PE (PE group, n = 66) compared with healthy, non-pregnant women (CNP group, n = 40) and healthy pregnant women (CP group, n = 40). BLL was determined by inductively coupled plasma mass spectrometry (ICP-MS). The systolic blood pressure (SBP), diastolic blood pressure (DBP) and BLL in the CP group were significantly lower than in the PE group (p < 0.001). Logistic regression analyses of BLL showed a significant positive relationship with the presence of PE. Furthermore, both the SBP and DBP values were positively associated with BLL. This study indicates that preeclamptic women tend to present with significantly higher BLL compared to healthy pregnant women. There were no differences in the BLL between the CP and CNP groups.

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Chemical elements and preeclampsia - An overview of current problems, challenges and significance of recent research

Cited by 14 publications

References 82 publications

Selected Trace Elements in Egyptian Females with Preeclampsia

Selected Trace Elements in Egyptian Females with Preeclampsia

The Role of Inorganics in Preeclampsia Assessed by Multiscale Multimodal Characterization of Placentae

Lead Levels in Non-Occupationally Exposed Women with Preeclampsia

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