Chemical etching strategy to prepare microtubes of a hybrid organic cuprous halide

Xu, Siyu; Yang, Jie-Ru; Wu, Ying; Lin, Hang-qing; Jiang, Lin; Du, Ke‐Zhao

doi:10.1039/d2ce01558g

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…CBP was synthesized and crystallized using an electrochemical method (Figure A). , The phase purity was confirmed by powder X-ray diffraction (PXRD) analysis (Figure S1). The crystal structure of CBP consists of mononuclear [CuBr(PPh 3 ) 3 ], wherein one copper atom coordinates with three PPh 3 ligands and one Br atom (Figure B).…”

Section: Resultsmentioning

confidence: 99%

Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex

Xu,

Hao,

et al. 2024

J. Med. Chem.

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Using copper-ionophores to translocate extracellular copper into mitochondria is a clinically validated anticancer strategy that has been identified as a new type of regulated cell death termed "cuproptosis." This study reports a mitochondria-targeting Cu(I) complex, Cu(I)Br(PPh 3 ) 3 (CBP), consisting of a cuprous ion coordinated by three triphenylphosphine moieties and a Br atom. CBP exhibited antitumor and antimetastatic efficacy in vitro and in vivo by specifically targeting mitochondria instigating mitochondrial dysfunction. The cytotoxicity of CBP could only be reversed by a copper chelator rather than inhibitors of the known cell death, indicating copper-dependent cytotoxicity. Furthermore, CBP induced the oligomerization of lipoylated proteins and the loss of Fe−S cluster proteins, consistent with characteristic features of cuproptosis. Additionally, CBP induced remarkable intracellular generation of reactive oxygen species (ROS) through a Fenton-like reaction, indicating a complex antitumor mechanism. This is a proof-ofconcept study exploiting the antitumor activity and mechanism of the Cu(I)-based mitochondria-targeting therapy.

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Section: Resultsmentioning

confidence: 99%

Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex

Xu,

Hao,

et al. 2024

J. Med. Chem.

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“…Halide perovskites have become a research hotspot in fields such as chemistry, physics, and materials due to their excellent photoelectric properties, including long carrier diffusion lengths, low trap densities, tunable band gaps, and high photoluminescence quantum yields (PLQYs). − According to their structural connectivity, perovskites can be classified into zero-dimensional (0D), one-dimensional, two-dimensional, and three-dimensional. 0D halide perovskites with isolated metal halide octahedra have received widespread attention due to their efficient broadband emission attributed to self-trapped exciton (STE) emission. , On the other hand, 0D halide perovskites can adopt various organic cation and guest metal ions, which can tune emissions as desired. − …”

Section: Introductionmentioning

confidence: 99%

Optical Property Regulation through Host–Guest Interaction in a Zero-Dimensional Zr Chloride

Lin,

Lu,

Liu

et al. 2024

Chem. Mater.

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Halide perovskites, particularly zero-dimensional (0D) A 2 BX 6 -type structures, have garnered significant attention in diverse fields due to their exceptional photoelectric properties. This study focuses on the optical property regulation of 0D A 2 ZrCl 6 through nonprotonated cation substitution (A = [(CH 3 ) 3 SO] + and [(CH 3 ) 4 N] + ) combined with different guest ions (i.e., Sb 3+ , Bi 3+ , and Mn 2+ ). The varied host−guest interaction is regarded as the reason for the different luminescent behaviors. The Sb 3+ dopant has a weaker interaction with the host [ ( C H 3 ) 3 S O ] 2 Z r C l 6 t h a n M n 2 + d o e s . A s a r e s u l t , Sb 3+ @[(CH 3 ) 3 SO] 2 ZrCl 6 shows an excitation-dependent photoluminescence ranging from blue to orange, while Mn 2+ @[(CH 3 ) 3 SO] 2 ZrCl 6 exhibits only Mn 2+ dopant emission under different excitation wavelengths. Besides the dopant effect on the host−guest interaction, the organic cation can impact the host−guest behavior as well. [(CH 3 ) 3 SO] 2 ZrCl 6 and [(CH 3 ) 4 N] 2 ZrCl 6 have different preferences for dopant ions. Sb 3+ and Mn 2+ are favorable in the host [(CH 3 ) 3 SO] 2 ZrCl 6 , while Sb 3+ and Bi 3+ are adopted in [(CH 3 ) 4 N] 2 ZrCl 6 . Due to the varied emission colors from Sb 3+ and Bi 3+ dopants, [(CH 3 ) 4 N] 2 ZrCl 6 possesses diverse photoluminescence behaviors through dopant engineering. Inside [(CH 3 ) 4 N] 2 ZrCl 6 , Sb 3+ and Bi 3+ have a weak host−guest interaction, showing a varied PL from the host and guest emission centers under different excitations.

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Organic Ligand Exchange: The Chiral Structure–Property Regulation of Cuprous Halides

Gao,

Xu,

et al. 2024

Inorg. Chem.

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The strategy of organic ligand exchange is proposed to tune the optical properties of organic−inorganic hybrid cuprous halides. In this work, the chiral ligand (S)-(−)-2,2′-bis(di-ptolylphosphino)-1,1′-binaphthyl ((S)-Tol-BINAP) and achiral triphenylphosphine (PPh 3 ) are introduced into cuprous halides CuX-PPh 3 -[(S)-Tol-BINAP] (X = Cl, Br, I) through organic ligand exchange. As a result, the mixed organic ligands can enhance second harmonic generation (SHG) and aggregation-induced emission (AIE) optical properties. Moreover, the title compounds exhibit progressively enlarged SHG effects along with heavier halogen substitution due to their stronger polarizability. In the meantime, the reduced π−π stacking interaction of the organic ligand will improve their photoluminescence quantum yield. The experimental results combined with the theoretical calculation clarify the structure−property relationship well. Furthermore, the title compounds have been developed for the application of latent fingerprint detection.

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Chemical etching strategy to prepare microtubes of a hybrid organic cuprous halide

Abstract: In this paper, we synthesized a layered crystals of bis(μ2-Chlor)-tris(triphenylphosphine)-di-copper(i) (CTC) and bis(μ2-bromo)-tris(triphenylphosphine)-di-copper(i) (BTC) by electrochemical synthesis in an ambient environment. The crystal stands on-edge to copper substrate in the...

Cited by 4 publications

References 47 publications

Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex

Antitumor Activity and Mechanistic Insights of a Mitochondria-Targeting Cu(I) Complex

Optical Property Regulation through Host–Guest Interaction in a Zero-Dimensional Zr Chloride

Organic Ligand Exchange: The Chiral Structure–Property Regulation of Cuprous Halides

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