CHEMICAL EVIDENCE FOR THE MULTIPLICITY OF THE ANTIBIOTICS PRODUCED BY <i>BACILLUS POLYMYXA</i>

Jones, Tudor S. G.

doi:10.1111/j.1749-6632.1949.tb27317.x

Cited by 47 publications

(8 citation statements)

References 11 publications

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“…The high diversity in chemical structure and LPs-producing microorganisms suggests that the LPs compounds may serve different and possibly multiple purposes. Polymyxin A is the example of lipopeptide with an antimicrobial activity which isolated from the soil bacterium Bacillus polymyxa [2]. Recently, several lipopeptides with diverse activities have been characterized, namely, as cytotoxic [3], antibacterial [4, 5], antifungal [6, 7], antiviral [8, 9], plant pathogenicity [10, 11], and anticancer [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Synergistic Antimicrobial Evaluation of Lipopeptides from Bacillus amyloliquefaciens Isolated from Oil-Contaminated Soil

Sudarmono

Wibisana²,

Listriyani³

et al. 2019

International Journal of Microbiology

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Lipopeptides show great potential for biomedical application. Several lipopeptides exhibit narrow and broad-spectrum inhibition activities. The aim of the study is to characterize the lipopeptides produced by B. amyloliquefaciens strain MD4-12 and evaluate the synergistic antimicrobial activity in combination with a conventional antibiotic against Gram-negative bacteria. B. amyloliquefaciens strain MD4-12 was isolated from oil-contaminated soil. The isolate was cultivated in McKeen medium, and the lipopeptides were isolated by precipitation and extraction with methanol. Characterization of the lipopeptides by ESI-MS gave nine mass ion peaks with m/z 994–1072, resulted from protonating of the main ions in [M + H]+ and [M + Na]+ ion form. These mass ion peaks attributed to surfactin homologs. By tandem mass spectrometry, five variants of surfactin with the same amino acid sequence in peptide moiety could be revealed. The peptide moiety contains seven amino acids identified as Glu-Leu/Ile-Leu-Val-Asp-Leu-Leu/Ile while the fatty acid moiety comprises a different length of chain from C12 to C16. Surfactin showed antibacterial activity against various Gram-positive and Gram-negative bacteria. Combination surfactin with ampicillin showed a synergistic effect against P. aeruginosa ATCC 27853.

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Section: Introductionmentioning

confidence: 99%

Characterization and Synergistic Antimicrobial Evaluation of Lipopeptides from Bacillus amyloliquefaciens Isolated from Oil-Contaminated Soil

Sudarmono

Wibisana²,

Listriyani³

et al. 2019

International Journal of Microbiology

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“…Polymyxins are a family of closely related cyclic lipopeptide antibiotics originally isolated in the late 1940s from the soil bacterium Bacillus polymyxa [58]. They are membrane active molecules with high affinity for the lipid A component of the LPS, and are characterized by poor tissue penetration, a molecular weight of approximately 1100, and activity directed predominantly against Gramnegative aerobes.…”

Section: Polymyxins and Derivativesmentioning

confidence: 99%

Lipopeptides as anti-infectives: a practical perspective

et al. 2009

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Abstract:Lipopeptide antibiotics represent an old class of antibiotics that were discovered over 50 years ago, which includes the old polymyxins but also new entries, such as the recently approved daptomycin. They generally consist of a hydrophilic cyclic peptide portion attached to a fatty acid chain which facilitates insertion into the lipid bilayer of bacterial membranes. This review presents an overview of this class of antibiotics, focusing on their therapeutic applications and putting particular emphasis on chemical modifications introduced to improve their activity.

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“…Jones (1949) bacillosporin C D Stansly, Shepherd 8r. With the polymyxins, however, the Gramnegative organisms are most susceptible.…”

Section: (D) Polyrnyxinmentioning

confidence: 99%

“…The polymyxin antibiotics deserve special mention in this connexion. Jones (1949) bacillosporin C D Stansly, Shepherd 8r. White (1947) polymyxin E Jones (1948) polymyxin It has been suggested that the structure of Gram-negative organisms closely resembles that of the human tissues and that an antibiotic affecting the Gramnegative organisms may be toxic.…”

Section: (D) Polyrnyxinmentioning

confidence: 99%

Some Polypeptide Antibiotics

Hirsch

1954

Journal of Applied Bacteriology

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CHEMICAL EVIDENCE FOR THE MULTIPLICITY OF THE ANTIBIOTICS PRODUCED BY BACILLUS POLYMYXA

Cited by 47 publications

References 11 publications

Characterization and Synergistic Antimicrobial Evaluation of Lipopeptides from Bacillus amyloliquefaciens Isolated from Oil-Contaminated Soil

Characterization and Synergistic Antimicrobial Evaluation of Lipopeptides from Bacillus amyloliquefaciens Isolated from Oil-Contaminated Soil

Lipopeptides as anti-infectives: a practical perspective

Some Polypeptide Antibiotics

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