Chemical examination of Tylophora asthmatica—V

Govindachari, T. R.; Pai, B. R.; Ragade, I. S.; Rajappa, S.; Viswanathan, N.

doi:10.1016/s0040-4020(01)92178-7

Cited by 23 publications

(12 citation statements)

References 8 publications

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“…In the event, by use of a chiral column we found tylophorine was not enantiomerically pure but a mixture of the laevo and dextrorotatory forms in the proportion 60 : 40. Apart from tylophorine, we also solved the structures of tylophorinine 11 and tylophorinidine 12 . The structure and absolute configuration of tylophorinidine has also been solved by X-ray studies 13 .…”

Section: Tylophora Alkaloidsmentioning

confidence: 99%

Five decades in the study of natural products

Govindachari¹

2002

J Chem Sci

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This paper describes the five-decade long fascinating journey taken by Prof. T R Govindachari towards the study of the natural products of India. A variety of Indian plants were investigated by him for the study of their constituent alkaloids and terpenoids. The concluding part of the paper summarizes the isolation and identification of the constituents of the Neem kernel, which eventually led to the first X-ray structure determination of azadirachtin A.

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Section: Tylophora Alkaloidsmentioning

confidence: 99%

Five decades in the study of natural products

Govindachari¹

2002

J Chem Sci

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“…The total alkaloid fraction of T. indica from above was resolved by chromatography. The alkaloids were characterized as tylophorine (4) (12), tylophorinine (6) (13,14), demethyltylophorine (7) (15), 4methoxy-14-hydroxytylophorine (8) (16), acctyl-O-methyltylophorinidine/acetyltylophorinine (9) (14, 17), and d-septicine (10) (16,17) according to the references given in brackets. The method for the separation and characterization of tylohirsutinine (11), 13a-methyltylohirsutine (12), 13a-methyltylohirsutinidine (13), tylohirsutinidine (14), 13a-hydroxytylophorine (15), 13a-hydroxysepticine (16), isotylocrebrime (17) (17), and 14-deoxy-13a-methyltylohirsutinidine (18) from T. hirsuta has been described by us else where (18)(19)(20).…”

Section: Separation and Characterization Of Phenanthroindolizidine Almentioning

confidence: 99%

Plant Based Antiamoebic Drugs; Part I. Antiamoebic Activity of Phenanthroindolizidine Alkaloids; Common Structural Determinants of Activity with Emetine

Bhutani¹,

Sharma²,

Ali³

1987

Planta Med

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Fourteen phenanthroindolizidine alkaloids which differ in number, nature, and distribution of oxygen-bearing substitucnts, in the presence of unsaturation in ring E or in the presence of an angular (methyl or hydroxyl) function or in the cleaved phenanthrene portion were isolated from two species of Tylophora plant. These along with the synthesized unsubstituted molecule and its intermediates were examined for their amoebicidal activity in vitro and all had been found active with varying MIC's. Structure-activity relationships were deduced and common sti-octural-determinants of this activity with emctine were found. The acute toxicity of tylophorine hydrochloride was determined and the same was found to be equally effective in intestinal as well as hepatic amoebiasis in test animals.

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“…The roots along with leaves of the plant are further employed to alleviate jaundice and liver disorders (Devprakash et al 2012). Tylophorinine, a minor alkaloid, was isolated and characterized from T. asthmatica by Govindachari et al (1961). Dhiman et al (2013) isolated and characterized a novel phenanthroindolizidine alkaloid, 3-O-demethyl tylophorinidine (VI), from the leaves and stems of T. indica by utilizing various chromatographic and spectroscopic techniques.…”

Section: Introductionmentioning

confidence: 99%