2008
DOI: 10.1016/j.jmr.2008.05.026
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Chemical exchange saturation transfer by intermolecular double-quantum coherence

Abstract: A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is based on the dependence on the m-th power of the initial magnetization (where m is the coherence order used). In this article we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relev… Show more

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Cited by 26 publications
(19 citation statements)
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“…Figure 22 (71). At physiological temperature this dual probe acts as CEST agent, whereas at temperatures higher than the gel-to-liquid transition phase of the liposome membrane components (38 8C), the vesicles release their content, the CEST contrast vanishes and the 19 F-MR signal appears as the result of the removal of the paramagnetically induced broadening of the 19 F peak of the PF 6 label (Fig. 23).…”
Section: Temperature Reportersmentioning
confidence: 98%
See 1 more Smart Citation
“…Figure 22 (71). At physiological temperature this dual probe acts as CEST agent, whereas at temperatures higher than the gel-to-liquid transition phase of the liposome membrane components (38 8C), the vesicles release their content, the CEST contrast vanishes and the 19 F-MR signal appears as the result of the removal of the paramagnetically induced broadening of the 19 F peak of the PF 6 label (Fig. 23).…”
Section: Temperature Reportersmentioning
confidence: 98%
“…Finally, enhancement of the CEST contrast has been also obtained by exploiting acquisition methods based on intermolecular double quantum coherence (19,20). (5)- (8) and (10)- (11).…”
Section: Practical Caveatsmentioning
confidence: 99%
“…The gag molecule also contains an amide proton at 3.2 ppm downfield of water, but its CEST effect is much smaller, because of the difference in exchange rate and availability of one amide proton vs. the three hydroxyl protons. Experiments at 3 and 7 T have shown a correlation of gagCEST with sodium ( 23 Na) MRI, 178,179 but not necessarily with 1 H MRI T 2 maps. 180 The effect is not easy to detect because of the close proximity to the water resonance, possibly leading to erroneous direct saturation contributions if the water offset is not precise in each voxel.…”
Section: Glycosaminoglycan Cest (Gagcest)mentioning
confidence: 99%
“…Intermolecular multiple quantum coherences (iMQCs [1][2][3][4]) can provide a valuable contrast in both NMR spectroscopy and imaging (MRI) [5][6][7][8][9][10][11][12][13][14][15][16][17]. This is the result of iMQCs' peculiar dependence on inter-spin distances, typically in the order of 0.05-1 mm, of their dependence on the medium's mesoscopic morphological and susceptibility properties, and of their nonlinear variation with the size of the magnetization.…”
Section: Introductionmentioning
confidence: 99%
“…This is the result of iMQCs' peculiar dependence on inter-spin distances, typically in the order of 0.05-1 mm, of their dependence on the medium's mesoscopic morphological and susceptibility properties, and of their nonlinear variation with the size of the magnetization. These features have led to a number of alternative approaches for exciting iMQC states, and to numerous ways of monitoring their consequences on different NMR and MRI experiments [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. The basic iMQC pulse sequence relies on the CRAZED scheme initially proposed by Warren and coworkers [1], whereby non-linear elements in the density matrix are excited and allowed to generate observable single-quantum signals with the aid of suitably set magnetization gratings:…”
Section: Introductionmentioning
confidence: 99%