Chemical food contaminants in the initiation of cancer

Tricker, Anthony R.; Preußmann, R.

doi:10.1079/pns19900019

Cited by 20 publications

(6 citation statements)

References 33 publications

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“…About 30% of human cancers are caused by low exposure to initiating carcinogenic contaminants in the diet (Tricker & Preussmann, 1990). Such contaminants include microminerals (when higher than normal) and heavy metals.…”

Section: Introductionmentioning

confidence: 99%

Concentrations of Mn, Fe, Cu, Zn, Cr, Cd, Pb, Ni in selected Nigerian tubers, legumes and cereals and estimates of the adult daily intakes

Akinyele

Shokunbi

2015

Food Chemistry

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Section: Introductionmentioning

confidence: 99%

Concentrations of Mn, Fe, Cu, Zn, Cr, Cd, Pb, Ni in selected Nigerian tubers, legumes and cereals and estimates of the adult daily intakes

Akinyele

Shokunbi

2015

Food Chemistry

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“…It has been proposed that about 30% of human cancers are caused by low exposure to initiating carcinogenic contaminants in the diet. 210 Moreover, food consumption has been identified as the major pathway for human exposure to environmental contaminants, accounting for more than 90% of intake compared to inhalation or dermal routes of exposure. 211 Monitoring of some PCBs congeners in different components of the aquatic ecosystem representing River Nile branches and estuaries, lakes, and some locations on the Mediterranean and the Red Seas has been carried out by several investigators.…”

Section: Food Contamination With Nonpesticidal Popsmentioning

confidence: 99%

Persistent organic pollutants (POPs) in Africa: Egyptian scenario

Mansour

2009

Hum Exp Toxicol

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Persistent organic pollutants (POPs) are organic (carbon-based) compounds that include synthesized substances (pesticides and polychlorinated biphenyls [PCBs]) and other by-product substances generated as a result of human and natural activity (dioxins and furans). Extensive scientific studies have shown that POPs are some of the most dangerous pollutants released into the environment by humans. Great efforts have been made since the early 1960s to enhance chemical management and safety issues. Various conventions have been adopted for this purpose: the Stockholm Convention (SC) is one of the well-known meetings in this context. The SC on POPs (May 2001) focuses on reducing and eliminating releases of 12 POPs coined the ‘Dirty Dozen’ by the United Nations Environment Program (UNEP). Persistence of such chemicals in soils, air, and water, together with natural processes such as evaporation to the atmosphere and washout by rain and flood, give rise to their ubiquitous distribution in the environment and eventual penetration into food chains and bio-accumulation in humans. Public concern about contamination by POPs increased recently because several of these compounds are identified as hormone disruptors, which can alter normal function of endocrine and reproductive systems in humans and wildlife. African countries are using pesticides, such as dichlorodiphenyltrichloroethane (DDT), lindane, toxaphene, endrin, dieldrin, heptachlor, since more than 50 years for combating agricultural pests and controlling disease vectors, especially malaria. The way in which pesticides are used in Africa caused serious environmental and health problems much more than elsewhere. These problems are represented by accumulation of organochlorine pesticide (OCP) residues in different environmental samples and hosting of at least 50,000 tons of obsolete pesticides, as well as tens of thousands of tons of contaminated soil. Within the framework of the Africa Stockpiles Program (ASP), huge quantities of pesticidal POPs have been completely or partially destroyed in a number of African countries (e.g. Egypt, Namibia, Niger, Senegal, Seychelles, South Africa, Sudan, Tanzania, Uganda, Zambia). At regional level (i.e. African Countries), a strategic plan for monitoring and getting rid of POPs in the continent should be set up and implemented through coordination between all governments. Among issues of top priorities are to find alternative non-combustion technologies for disposing obsolete pesticides, and to use alternative control measures for mosquitoes’ management and other vector-borne diseases.

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“…Fresh fruits and vegetables are considered a major source of nutrients in the human daily diet but can also be a source of contaminants, such as toxic metals or other toxic components present in pesticides (Tricker and Preussmann 1990, D´Mello 2003, Mahmood and Malik 2014. Consumption of contaminated food has been identified as a major pathway of human exposure to contaminants, and over 90% of all existing ingestible contaminants are present in food (Fries 1995, Järup 2003, Järup and Åkesson 2009, Cherfi et al 2014, Duan et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Dietary intake and trophic transfer of cadmium and lead from three daily consumption vegetables in Quito, Ecuador

Vela,

Simbaña-Farinango,

Navarrete

et al. 2023

Rev. Int. Contam. Ambie.

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The presence of toxic metals in vegetables of daily consumption is a concern for human health. Little is known about the concentration of toxic metals in vegetables sold in markets in Quito, Ecuador, and the corresponding risk to the population. This study aimed to measure the concentration of cadmium (Cd), and lead (Pb) in tomatoes, carrots, and lettuce, to estimate the risk for human health, and to determine the trophic transfer factor using Drosophila melanogaster flies. Vegetable samples were obtained from four local markets in Quito to measure the concentration of Cd and Pb (expressed in mg/kg of dry weight) in the vegetables by microwave-assisted acid digestion and atomic absorption spectrophotometry. Drosophila melanogaster flies were fed with contaminated vegetables to determine de trophic transfer factor of metals in the trophic chain. Our results showed the highest accumulation of Pb and Cd occurred in lettuce. In all cases, the Pb and Cd concentrations exceeded the maximum levels established by the Food and Agriculture Organization. However, the daily intake of metals and the health risk index showed no risk from daily consumption. Pb’s trophic transfer factor was excessively high in the tomato-fed flies, showing transference and accumulation in the flies. Cadmium concentration in tomato-fed flies was also the highest among the three vegetables. The trophic chain transfer of toxic metals from vegetables to Drosophila has been observed through a high accumulation of these metals in flies, and this suggests a negative impact on both human health and ecosystems.

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Chemical food contaminants in the initiation of cancer

Cited by 20 publications

References 33 publications

Concentrations of Mn, Fe, Cu, Zn, Cr, Cd, Pb, Ni in selected Nigerian tubers, legumes and cereals and estimates of the adult daily intakes

Concentrations of Mn, Fe, Cu, Zn, Cr, Cd, Pb, Ni in selected Nigerian tubers, legumes and cereals and estimates of the adult daily intakes

Persistent organic pollutants (POPs) in Africa: Egyptian scenario

Dietary intake and trophic transfer of cadmium and lead from three daily consumption vegetables in Quito, Ecuador

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