Chemical hydrophobisation of silica-based porous particles with n-Octadecyltrichlorosilane (ODTCS) by a solventless process in a fluidised-bed reactor

Saleh, Khashayar; Lazghab, Myriam; Guigon, Pierre

doi:10.1016/j.powtec.2008.04.088

Cited by 3 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dominant functional groups of the silica surfaces are siloxane (Si-O-Si) and silanol (-Si-OH) groups, which render these materials highly hygroscopic, and the presence of surface silanol groups also implies functionality to allow the better control of drug loading and release [12][13][14]. By functionalizing the surface, the new functional groups can develop strong interactions, which may lead to drug release retardation [15][16][17]. However, in an utterly different approach, the contribution of attractive drug-surface interactions is not necessarily increased, but the hydrophilicity of the silica carrier is decreased.…”

Section: Introductionmentioning

confidence: 99%

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

et al. 2021

View full text Add to dashboard Cite

Background: The drug release of antiparkinsonian drugs is an important issue during the formulation process because proper release kinetics can help to reduce the off periods of Parkinson’s disease. A 2-factor, 3-level (32) full-factorial design was conducted to evaluate statistically the influence of the hydrophobicity of mesoporous silica on drug release. Methods: Hydrophobization was evaluated by different methods, such as contact angle measurement, infrared spectroscopy and charge titration. After loading the drug (levodopa methyl ester hydrochloride, melevodopa hydrochloride, LDME) into the mesopores, drug content, particle size, specific surface area and homogeneity of the products were also analyzed. The amorphous state of LDME was verified by X-ray diffractometry and differential scanning calorimetry. Results: Drug release was characterized by a model-independent method using the so-called initial release rate parameter, as detailed in the article. The adaptability of this method was verified; the model fitted closely to the actual release results according to the similarity factor, independently of the release kinetics. Conclusions: The API was successfully loaded into the silica, resulting in a reduced surface area. The release studies indicated that the release rate significantly decreased (p < 0.05) with increasing hydrophobicity. The products with controlled release can reduce the off period frequency.

show abstract

Section: Introductionmentioning

confidence: 99%

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Finally, we choose to use carboxy‐terminal domains of collagen exposing hydroxyl groups usable for silanization 13, 14. For silanization we used either octadecyltrichlorosilane (OTS), which has been previously investigated for the chemical hydrophobization of silica surfaces, or octadecyltriethoxysilane (OTES) 15, 16. Silanization was first performed with OTS in dichloromethane (DCM); then silanization was repeated with other, more biocompatible solvents, such as ethanol for OTES and ethyl acetate or acetone for OTS.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 For silanization we used either octadecyltrichlorosilane (OTS), which has been previously investigated for the chemical hydrophobization of silica surfaces, or octadecyltriethoxysilane (OTES). 15,16 Silanization was first performed with OTS in dichloromethane (DCM); then silanization was repeated with other, more biocompatible solvents, such as ethanol for OTES and ethyl acetate or acetone for OTS. The effects of different surface modifications were investigated by contact angle measurement, Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM).…”

Section: Introductionmentioning

confidence: 99%

Root canal hydrophobization by dentinal silanization: Improvement of silicon‐based endodontic treatment tightness

et al. 2013

View full text Add to dashboard Cite

A new strategy to improve silicon‐based endodontic treatment tightness by dentine hydrophobization is presented in this work: root dentine was silanized to obtain a hydrophobic dentine‐sealer interface that limits fluid penetration. This strategy was based on the grafting of aliphatic carbon chains on the dentine through a silanization with the silane end groups [octadecyltrichlorosilane (OTS) and octadecyltriethoxysilane]. Dentine surface was previously pretreated, applying ethylenediaminetetraacetic acid and sodium hypochlorite, to expose hydroxyl groups of collagen for the silane grafting. Collagen fibers exposure after pretreatment was visible with scanning electron microscopy, and Fourier transform infrared (FTIR) spectroscopy showed their correct exposition for the silanization (amide I and II, with 1630, 1580, and 1538 cm‐1 peaks corresponding to the vibration of CO and CN bonds). The grafting of aliphatic carbon chains was confirmed by FTIR (peaks at 2952 and 2923 cm‐1 corresponding to the stretching of CH bonds) and by the increasing of the water contact angle. The most efficient hydrophobization was obtained with OTS in ethyl acetate, with a water contact angle turning from 51° to 109°. Gas and liquid permeability tests showed an increased seal tightness after silanization: the mean gas and water flows dropped from 2.02 × 10‐8 to 1.62 × 10−8 mol s‐1 and from 10.8 × 10−3 to 5.4 × 10−3 µL min−1, respectively. These results show clear evidences to turn hydrophilic dentine surface into a hydrophobic surface that may improve endodontic sealing. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.

show abstract

Effect of operating conditions on the hydrophobisation of silica-based porous particles in a fluidised-bed reactor: Temperature effect

Bénali

Aillet

Saleh

2012

Advanced Powder Technology

View full text Add to dashboard Cite

Chemical hydrophobisation of silica-based porous particles with n-Octadecyltrichlorosilane (ODTCS) by a solventless process in a fluidised-bed reactor

Cited by 3 publications

References 29 publications

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

Root canal hydrophobization by dentinal silanization: Improvement of silicon‐based endodontic treatment tightness

Effect of operating conditions on the hydrophobisation of silica-based porous particles in a fluidised-bed reactor: Temperature effect

Contact Info

Product

Resources

About