Chemical Imaging Optimization of Light Addressable Potentiometric Sensor on Amplitude‐Phase Mode

Abstract

Light‐addressable potentiometric sensor (LAPS) is one of the label‐free chemical imaging sensors and attractive for its flexible imaging capability coming from its unique addressing mechanism. Imaging quality of LAPS is limited by illumination intensity and stability of light source. In this study, the amplitude‐phase mode, which combines the advantages of constant‐bias mode and phase mode, is proposed. The role of amplitude‐phase mode in suppressing illumination interference and improving imaging quality has been theoretically proven. Better spatial resolution and the more realistic imaging effect are realized by LAPS in amplitude‐phase mode. The amplitude‐phase mode LAPS provides a feasible implementation for improving LAPS spatial resolution under a reducing illumination intensity.