Chemical interaction between PVDF and Li cations during LiCl crystallization in VMCr

Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

“…In addition, membrane separation technology coupled with crystallization has been successfully applied to produce coated drug particles with better morphology and narrower crystal size distribution. − In the membrane crystallization process, the spatial and temporal distributions of supersaturation were effectively regulated, and the control accuracy of crystallization was improved to achieve continuous production of high-purity products. , Membrane-assisted antisolvent crystallization via a hollow fiber membrane module was applied to drug preparation with improved crystal size distribution (CSD) by Zarkadas et al Through long-term research and development, hollow fiber membrane-assisted antisolvent crystallization (MAAC) was usually operated by adding an antisolvent in the tube side and crystallizing in the shell side to avoid membrane module clogging for continuous operation . In the authors’ previous work, MAAC was developed to add the antisolvent through the hollow fiber membrane interface, with higher microscopic mixing scale and higher mixing efficiency of the antisolvent and drug solution. − A simple pressure-driven model and the theory of interfacial liquid layer mass transfer in MAAC were proposed and confirmed.…”