Chemical Investigation of Wild Cannabis Sativa L. Roots

Vk, Sethi; Mp, Jain; Rs, Thakur

doi:10.1055/s-0028-1097617

Cited by 18 publications

(13 citation statements)

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“… 60 Future research should compare the phytochemistry of hemp roots with those from various drug chemovars to determine if there are differences in active compounds. Furthermore, reports of carvone and dihydrocarvone in significant amounts 20 and other potential monoterpenes in cannabis roots must be confirmed. Modern studies using the same terpenoids found in cannabis roots have shown anti-inflammatory and pain-relieving activities.…”

Section: Summary and Future Directionsmentioning

confidence: 98%

“…Sethi et al 20 collected wild cannabis roots from Jammy, India. From an initial 2 kg sample of dried powdered roots, the extraction assay revealed 15 mg of friedelin, 29 mg epifriedelanol, and 30 mg of beta-sitosterol.…”

Section: Active Compounds In Cannabis Rootsmentioning

confidence: 99%

“…Cannabis roots have also been shown to contain N -( p -hydroxy- β -phenylethyl)- p -hydroxy- trans -cinnamamide, at calculated concentration of 1.6 mg/kg, with analgesic activity in the mouse tail flick test at 25, 50, and 100 mg/kg via subcutaneous injection. 18 Carvone, as identified in cannabis root from India by Sethi et al, 20 also has antinociceptive activity. 37 , 38 In the acetic acid-induced writhing test, carvone-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg were administered through intraperitoneal (IP) injection.…”

Section: Modern Studies On Biochemical Activity Of Compounds Found Inmentioning

confidence: 99%

“…It is important to note that past studies have included analysis of roots of C. sativa from various regions of the world, including Mexico 24 , 25 , 29 and India. 20 The plant genus Cannabis is a member of the family Cannabaceae, and while some botanists argue for cannabis as a single species, others describe up to four, including C. sativa , Cannabis indica , Cannabis ruderalis , and Cannabis afghanica (or kafiristanica ). 58 , 59 It is clear there are many different chemotypes of cannabis, including THC predominant, CBD predominant, and mixed types.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

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Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain

Ryz¹,

Remillard²,

Russo³

2017

Cannabis and Cannabinoid Research

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Introduction: The roots of the cannabis plant have a long history of medical use stretching back millennia. However, the therapeutic potential of cannabis roots has been largely ignored in modern times.Discussion: In the first century, Pliny the Elder described in Natural Histories that a decoction of the root in water could be used to relieve stiffness in the joints, gout, and related conditions. By the 17th century, various herbalists were recommending cannabis root to treat inflammation, joint pain, gout, and other conditions. There has been a subsequent paucity of research in this area, with only a few studies examining the composition of cannabis root and its medical potential. Active compounds identified and measured in cannabis roots include triterpenoids, friedelin (12.8 mg/kg) and epifriedelanol (21.3 mg/kg); alkaloids, cannabisativine (2.5 mg/kg) and anhydrocannabisativine (0.3 mg/kg); carvone and dihydrocarvone; N-(p-hydroxy-β-phenylethyl)-p-hydroxy-trans-cinnamamide (1.6 mg/kg); various sterols such as sitosterol (1.5%), campesterol (0.78%), and stigmasterol (0.56%); and other minor compounds, including choline. Of note, cannabis roots are not a significant source of Δ9-tetrahydrocannabinol (THC), cannabidiol, or other known phytocannabinoids.Conclusion: The current available data on the pharmacology of cannabis root components provide significant support to the historical and ethnobotanical claims of clinical efficacy. Certainly, this suggests the need for reexamination of whole root preparations on inflammatory and malignant conditions employing modern scientific techniques.

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Section: Summary and Future Directionsmentioning

confidence: 98%

Section: Active Compounds In Cannabis Rootsmentioning

confidence: 99%

Section: Modern Studies On Biochemical Activity Of Compounds Found Inmentioning

confidence: 99%

Section: Summary and Future Directionsmentioning

confidence: 99%

See 2 more Smart Citations

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain

Ryz¹,

Remillard²,

Russo³

2017

Cannabis and Cannabinoid Research

View full text Add to dashboard Cite

show abstract

“…Cannabis roots have proven to harbor terpenoids, sterols [106], and alkaloids [107] [88] shows strong concordance in symptomatic relief claimed.…”

Section: History Of Medicinalmentioning

confidence: 99%

History of Cannabis and Its Preparations in Saga, Science, and Sobriquet

Russo

2007

ChemInform

118

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Cannabis sativa L. is possibly one of the oldest plants cultivated by man, but has remained a source of controversy throughout its history. Whether pariah or panacea, this most versatile botanical has provided a mirror to medicine and has pointed the way in the last two decades toward a host of medical challenges from analgesia to weight loss through the discovery of its myriad biochemical attributes and the endocannabinoid system wherein many of its components operate.This study surveys the history of cannabis, its genetics and preparations. A review of cannabis usage in Ancient Egypt will serve as an archetype, while examining first mentions from various Old World cultures and their pertinence for contemporary scientific investigation. Cannabis historians of the past have provided promising clues to potential treatments for a wide array of currently puzzling medical syndromes including chronic pain, spasticity, cancer, seizure disorders, nausea, anorexia, and infectious disease that remain challenges for 21st century medicine. Information gleaned from the history of cannabis administration in its various forms may provide useful points of departure for research into novel delivery techniques and standardization of cannabis-based medicines that will allow their prescription for treatment of these intractable medical conditions.

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History of Cannabis and Its Preparations in Saga, Science, and Sobriquet

Russo

2007

Chemistry & Biodiversity

459

204

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Cannabis sativa L. is possibly one of the oldest plants cultivated by man, but has remained a source of controversy throughout its history. Whether pariah or panacea, this most versatile botanical has provided a mirror to medicine and has pointed the way in the last two decades toward a host of medical challenges from analgesia to weight loss through the discovery of its myriad biochemical attributes and the endocannabinoid system wherein many of its components operate. This study surveys the history of cannabis, its genetics and preparations. A review of cannabis usage in Ancient Egypt will serve as an archetype, while examining first mentions from various Old World cultures and their pertinence for contemporary scientific investigation. Cannabis historians of the past have provided promising clues to potential treatments for a wide array of currently puzzling medical syndromes including chronic pain, spasticity, cancer, seizure disorders, nausea, anorexia, and infectious disease that remain challenges for 21st century medicine. Information gleaned from the history of cannabis administration in its various forms may provide useful points of departure for research into novel delivery techniques and standardization of cannabis-based medicines that will allow their prescription for treatment of these intractable medical conditions.

show abstract

Chemical Investigation of Wild Cannabis Sativa L. Roots

Cited by 18 publications

References 1 publication

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain

History of Cannabis and Its Preparations in Saga, Science, and Sobriquet

History of Cannabis and Its Preparations in Saga, Science, and Sobriquet

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