Chemical Liaison Between Diabetes and Hypertension, Depression and Socio-economic Deprivation Impact in Both

Furau, Roxana; Popa, Amorin Remus; Socea, Bogdan; Dimitriu, Mihai; Precup, Cris; Furau, Gheorghe; Onel, Mircea; Romosan, R.; Gheroghiu, Diana Claudia; Gheroghiu, Nicolae; Furău, Cristian

doi:10.37358/rc.19.8.7468

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…The best indicator of vitamin D status in the body is considered to be serum 25-hydroxyvitamin D, 25-[OH]D [1][2]. This is known to be the renal and nonrenal synthesis precursor for 1,25dihydroxyvitamin D, 1,25-[OH]2D (calcitriol) which, opposed to the previous, has a greater biological half-life of three weeks and higher circulating levels [3][4][5][6][7]. Serum 1,2D is the biologically active form of vitamin D that is responsible for most of the vitamin D actions and it does not cross the placenta [2].…”

Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

“…Its action is focused on the three target organs, intestine, kidney, and bone, in which specific nuclear receptors (VDRs) are well expressed [3]. The studies and experiments conducted in vitro and in vivo have shown that vitamin D exerts other "non-calcium" actions also [1][2][3][4][5][6]. It was demonstrated that vitamin D receptors are located in the entire body tissues [1].…”

Section: Introductionmentioning

confidence: 99%

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Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Petroaie¹,

Popovici²,

Cosmescu³

et al. 2020

Rev. Chim.

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One of the essential roles of vitamin D is to maintain a good state of health, its actions being extremely complex. In the past years, the role and involvement of vitamin D have been intensively discussed in a variety of physiological or pathological conditions. To be effective, vitamin D requires binding to specific nuclear receptors (VDRs) that are found in multiple tissues. Therefore, there is a great interest in studies focused on vitamin D in order to evaluate the potential functions and relations with gestational diabetes mellitus (GDM). This disease is defined by glucose intolerance with onset or first recognition during pregnancy. It presents an increased risk of later progression to type 2 diabetes. Now, gestational diabetes represents a global public health problem due to its increasing incidence and possible severe complications of pregnancy. This article centralizes recent studies focused on a possible link between vitamin D deficiency and gestational diabetes, knowing that in pregnant women the insufficiency or deficiency of that vitamin is a common thing.

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Section: Metabolism Of Vitamin D During the Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Petroaie¹,

Popovici²,

Cosmescu³

et al. 2020

Rev. Chim.

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show abstract

“…Because the patient initially refused surgery, treatment with pasireotide was initiated at a dose of 0.6 mg twice daily. After 18 months she experienced spectacular weight loss of 32 kg, her blood pressure normalized, requi- a higher frequency of hyperglycemia 2,[6][7][8] . In a metaanalysis, mild side eff ects were observed in 39.3% of patients and severe side eff ects were observed in 15.2% of patients, respectively 1 .…”

Section: Case Presentationmentioning

confidence: 99%

Pasireotide after Surgery for Persistent Cushing’s Disease

Păduraru¹,

Scanteie²,

Bolocan³

et al. 2019

Rev. Med. Mod.

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Introduction: Cushing's disease (CD) is characterized by multiple complications, particularly due to the condition itself, but also as a result of curative treatment. Nowadays, transsphenoidal surgery is considered the fi rst-line therapy. Persistent hypercortisolism requires the initiation of medical therapy in order to limit the consequences of the disease. A common complication of pasireotide treatment is type 2 diabetes mellitus. We present a case of persistent Cushing's disease after transsphenoidal adenomectomy and pasireotide therapy, evaluated in several medical centers. Case presentation: A 27-year-old female was referred to our clinic for weight gain, hypertension, transient headache and recurrent depression. Clinical examination revealed plethoric moon face, purple striae, hirsutism with a Ferriman-Gallwey score of 14, acanthosis nigricans. The hormonal profi le showed high ACTH (adrenocorticotropic hormone) levels (of 110.6 pg/mL, normal: 7.2-63.3 pg/mL), high urinary free cortisol (UFC) (of 846.5 μg/24h, normal: 50-190 μg/24h) and serum cortisol, accompanied by non-suppression of cortisol after the 1 mg DXM (Dexamethasone) suppression test (of 26.6 μg/dL, normal: 18 μg/dL) and adequate suppression after the overnight 8 mg DXM test. Pituitary MRI (Magnetic Resonance Imaging) revealed a microadenoma measuring 4.3/4.4/6.2 mm. Transsphenoidal adenomectomy was recommended. After surgery, the patient developed multiple pituitary hormone defi ciency, without signifi cant remission of hypercortisolism. Pasireotide therapy was initiated, followed by inadequate control of hypercortisolism and the onset of type 2 diabetes mellitus, requiring oral antidiabetic agents and insulin. Conclusion: In persistent Cushing's disease, the challenge lies in identifying the optimal therapeutic methods in order to achieve a cure while, at the same time, limiting their side effects. Careful long-term follow-up by a multidisciplinary team is required.

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Chemical Liaison Between Diabetes and Hypertension, Depression and Socio-economic Deprivation Impact in Both

Cited by 2 publications

References 25 publications

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Is There a Relation Between 25-Hydroxyvitamin D Deficiency and Gestational Diabetess

Pasireotide after Surgery for Persistent Cushing’s Disease

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