Chemical markers from the peracid oxidation of isosafrole

Forensic Science

“…An on-site screening system for amphetaminetype stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer has been developed (449). Isomers of 2,4-dimethyl-3,5-bis(3,4-methylenedioxyphenyl)tetrahydrofuran (11) have been presented as chemical markers formed during the peracid oxidation of isosafrole (450). A LC-MS method for quantification of trimethoxyamphetamines in human urine after SPE with C 18 was developed and validated (451).…”

Manufacturing by-products from, and stereochemical outcomes of the biotransformation of benzaldehyde used in the synthesis of methamphetamine

“…Characterisation of the impurities was achieved by matching their retention times and mass spectra to those of chemical standards that were independently synthesised and their structures confirmed by NMR analysis. This approach has been used recently in the determination of chemical markers from the oxidation of safrole and isosafrole in the clandestine manufacture of MDMA [19,20]. In addition to this, the study aimed to determine the stereoselectivity of l-PAC 5 formed in the initial fermentation process and the stereochemistry of the subsequent reaction products through to the final methamphetamine 1.…”