Chemical Measurement and Analysis: from Phenomenon to Essence

Abstract

and has published more than 400 scientific papers. Her research interests focus on bioanalysis, single cell/single particle/single molecule measurement and imaging. Contents

Advances in electrochemiluminescence for single-cell analysis

“…As optical imaging instruments and techniques continue to improve, ultra-high sensitivity single-photon level optical detection devices (e.g., EMCCD) are being used in microscopy imaging systems. [103][104][105] Single-cell ECL microscopy (ECLM) holds significant potential for ultra-sensitive microscopy imaging that combines the advantages of chemiluminescence in detectability with improved resolution. A single-cell ECLM system consists of an electrochemical workstation, an electrochemical cell, a microscope with EMCCD and other optical components (e.g., objective, lens, etc.…”

Single‐Molecule Measurement of Carbonic Anhydrase in Cation Coordinated Environment Using MspA Nanopore†

“…[ 13‐15 ] Recently, those electrochemistry measurements are in a rapid developing pace, and have identified many biology blocks of great importance in living system. [ 16‐17 ] Feng and colleagues have created synthetic nanopore to mimic ionic channel which presents remarkable potassium‐selective transport. [ 18‐19 ] This work provides a new path to de novo design of protein channels with customized transmembrane traffic functions.…”

Stretchable Electrochemical Sensors: From Electrode Fabrication to Cell Mechanotransduction Monitoring†

“…With unique characteristics, such as rapid response, excellent sensitivity and high temporal‐spatial resolution, electrochemical sensing has been extensively used for the analysis of biomolecules ranging from ions, small molecules, nucleic acids to proteins both in vitro and in vivo . [ 1‐10 ] As regards electrochemical cytosensors, remarkable progresses have been made in electrochemical monitoring of life activities at bulk cells or single‐cell and even subcellular levels. In general, millimeter‐sized electrodes allow living cells to be cultured directly thereon, and this sensing mode combined with biorecognition strategies are widely employed to evaluate the metabolic activity of bulk cells.…”