Chemical Mixtures in the Environment: Exposure Assessment

Rice, Glenn; MacDonell, Margaret

doi:10.1002/9783527630196.ch2

Cited by 1 publication

(2 citation statements)

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“…Combined exposures depend not only on the characteristics of the sources, but also on those of the populations of receptors. Each individual in these populations will have a unique relationship to their sources of exposure [23,24]. Thus, a decision tree needs to be designed for evaluation of populations of exposed receptors and not around a specific source (or sources).…”

Section: Combined Exposures Reaching Thismentioning

confidence: 99%

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A decision tree for assessing effects from exposures to multiple substances

et al. 2012

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Background: The Cefic Mixtures Industry Ad-hoc Team (MIAT) has investigated how risks from combined exposures can be effectively identified and managed using concepts proposed in recent regulatory guidance, new advances in risk assessment, and lessons learned from a Cefic-sponsored case study of mixture exposures. Results: A series of tools were created that include: a decision tree, a system for grouping exposures, and a graphical tool (the MCR-HI plot). The decision tree allows the division of combined exposures into different groups, exposures where one or more individual components are a concern, exposures that are of low concern, and exposures that are a concern for combined effects but not for the effects of individual chemicals. These tools efficiently use available data, identify critical data gaps for combined assessments, and prioritize which chemicals require detailed toxicity information. The tools can be used to address multiple human health endpoints and ecological effects.

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Section: Combined Exposures Reaching Thismentioning

confidence: 99%

“…Combined exposures The measurements of the doses of multiple chemicals that reach an individual or an ecological receptor from one or more sources by one or more routes at the same time or within a period of time sufficiently short that the substances simultaneously evoke effects on the organism [24].…”

Section: Definitionsmentioning

confidence: 99%