Macrolide Antibiotics 2003
DOI: 10.1016/b978-012526451-8/50004-7
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Chemical Modification of Macrolides

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Cited by 8 publications
(3 citation statements)
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“…These milbemycins differ in methyl (A 3 ) or ethyl (A 4 ) substituent at the C-25 atom, and their mixture is directly used as acaricides (Milbemectin) in crop protection. The acaricides also serve as starting materials for semisynthetic production of milbemycin 5-hydroxyimino derivatives, resulting in a commercial product, Milbemycin oxime, suitable for veterinary purposes [ 3 ]. Taking into account acceptable pharmacokinetic and safety properties, milbemycin derivatives are also considered as potential drugs in human medicine [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…These milbemycins differ in methyl (A 3 ) or ethyl (A 4 ) substituent at the C-25 atom, and their mixture is directly used as acaricides (Milbemectin) in crop protection. The acaricides also serve as starting materials for semisynthetic production of milbemycin 5-hydroxyimino derivatives, resulting in a commercial product, Milbemycin oxime, suitable for veterinary purposes [ 3 ]. Taking into account acceptable pharmacokinetic and safety properties, milbemycin derivatives are also considered as potential drugs in human medicine [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…Products of the B‐series, characterized for possessing a 5'‐hydroxy group, are markedly more active than those of the A‐series, which contain a 5'‐methoxy group instead (Pitterna et al ., ; Wei et al ., ; Zhang et al ., ; Yoon et al ., ). However, it has been demonstrated that 1‐ and 2‐series products exert a similar activity against many parasites (Sunazuka et al ., ). In 1981, the antibiotic was refined by a reduction in the 22,23‐olefin of the most active avermectins, namely, B 1a and B 1b.…”
Section: Introductionmentioning
confidence: 99%
“…These scaffolds are present in many naturally occurring alkaloids. [12][13][14][15][16][17][18][19] The Fischer indolization reaction is an efficient way to construct fused indoline ringsystems, although several alternate methods have also been developed to access these biologically important motifs. 19,20 A variant of this reaction, the Garg interrupted Fischer indolization, has the advantage of producing three new bonds, two heterocyclic rings and two stereogenic centers, in one reaction.…”
Section: Introductionmentioning
confidence: 99%