Chemical Modification of Polysaccharides and Applications in Strategic Areas

Marques, Nívia do Nascimento; Alves, Keila dos Santos; Vidal, Rosangela Regia Lima; Maia, Ana Maria da Silva; Curti, Priscila Schroeder; Balaban, Rosângela de Carvalho

doi:10.1007/978-3-030-31403-3_17

Cited by 6 publications

(5 citation statements)

References 146 publications

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“…Regardless of the materials selected, further modifications may be required to create new and suitable properties. For instance, customizing the chemical structure of materials to obtain desired bulk properties has been sought through various strategies, including chemical modifications. ,, An exploration of altering the physical and biological characteristics of PSAs has also been conducted to fine-tune their properties.…”

Section: Discussionmentioning

confidence: 99%

Tailor-Made Polysaccharides for Biomedical Applications

Khodadadi Yazdi,

Seidi,

Hejna

et al. 2024

ACS Appl. Bio Mater.

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Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either in their pure form or in blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various biomedical applications by incorporating unique molecular structures and targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, and functionalization, have been explored to control their mechanical properties, electrical conductivity, hydrophilicity, degradability, rheological features, and stimuli-responsiveness. For instance, custom-made PSAs are known for their worldwide biomedical applications in tissue engineering, drug/gene delivery, and regenerative medicine. Furthermore, the remarkable advancements in supramolecular engineering and chemistry have paved the way for mission-oriented biomaterial synthesis and the fabrication of customized biomaterials. These materials can synergistically combine the benefits of biology and chemistry to tackle important biomedical questions. Herein, we categorize and summarize PSAs based on their synthesis methods, and explore the main strategies used to customize their chemical structures. We then highlight various properties of PSAs using practical examples. Lastly, we thoroughly describe the biomedical applications of tailor-made PSAs, along with their current existing challenges and potential future directions.

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Section: Discussionmentioning

confidence: 99%

Tailor-Made Polysaccharides for Biomedical Applications

Khodadadi Yazdi,

Seidi,

Hejna

et al. 2024

ACS Appl. Bio Mater.

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“…These include starch, chitin, and cellulose. [10,13,[31][32][33] However, many others with potentially revolutionary properties remain underutilized.…”

Section: Biopolymersmentioning

confidence: 99%

“…[8,9] Biopolymers and their derivatives by chemical modifications are promising candidates for electrospun fibers. [10] Polysaccharides are renewable, biodegradable, and abundant natural polymers, and include the most abundant polymers on Earth (cellulose and chitin). [11,12] Polysaccharides have, on average, three hydroxyls in each repeating unit, providing a large number of sites for chemical modifications.…”

Section: Introductionmentioning

confidence: 99%

Expanding the Repertoire of Electrospinning: New and Emerging Biopolymers, Techniques, and Applications

Madruga

Kipper

2021

Adv Healthcare Materials

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Electrospinning has emerged as a versatile and accessible technology for fabricating polymer fibers, particularly for biological applications. Natural polymers or biopolymers (including synthetically derivatized natural polymers) represent a promising alternative to synthetic polymers, as materials for electrospinning. Many biopolymers are obtained from abundant renewable sources, are biodegradable, and possess inherent biological functions. This review surveys recent literature reporting new fibers produced from emerging biopolymers, highlighting recent developments in the use of sulfated polymers (including carrageenans and glycosaminoglycans), tannin derivatives (condensed and hydrolyzed tannins, tannic acid), modified collagen, and extracellular matrix extracts. The proposed advantages of these biopolymer-based fibers, focusing on their biomedical applications, are also discussed to highlight the use of new and emerging biopolymers (or new modifications to well-established ones) to enhance or achieve new properties for electrospun fiber materials.

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“…Gheorghita et al 2021 [20] highlight polysaccharides in the pharmaceutical industries and as encapsulation materials for controlled drug delivery systems, including probiotics, focusing on their development and benefits. Bioplastic materials have several weaknesses in terms of their mechanical and barrier properties that have resulted in several studies on composite systems [21]. Hong et al in 2021 [22] present a review of bioplastics materials applied for food packaging, other possible materials, such as plastics, paper, metal, and glass, are also discussed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Chanar Gum Films

Lazo

Melo

Auad

et al. 2022

Colloids and Interfaces

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New polysaccharides are being intensely studied as sources of edible materials, with potential application in food packaging systems, eco-materials and the pharmaceutical industry. This investigation aimed to develop biopolymer films based on the polysaccharides obtained from chañar (CH) fruit (Geoffrea decorticans). The resulting polysaccharides, from hydrothermal extraction (CHT) and acid extraction (CHA) were hydrodynamically characterized, with density, viscosity, and diffusion coefficient measurements to obtain their properties in an aqueous solution (intrinsic viscosity, shape factor, partial specific volume, hydration value, molecular weight, and hydrodynamic radius). The polysaccharides films (CHTF and CHAF) were characterized with SEM/EDX, DSC, TGA-DTG, FTIR, DRX, mechanical tests, water vapor permeation, colorimetry, antioxidant capacity, and biodegradability, to determine potential applications based on these properties. The results indicated that the extraction method affects the hydrodynamic properties of the obtained polysaccharide. They differ in molecular weight, and RH of CHT was greater than CHA. Both gums were quasi-spherical, and the νa/b value of CHT was more than CHA. The films properties did not present significant differences in most cases. SEM micrographs illustrate that CHAF presents a much rougher surface. The results of the mechanical analysis show that CHTF has better mechanical properties, it has higher elongation at break and tensile strength, with a Young Modulus of 2.8 MPa. Thermal analysis indicates good thermal stability of the films until about 150 °C. The degradation study shows that CH films are biodegradable in a 35 day range. The study of this properties is critical to demonstrate the functionality of biopolymers and their application. The obtained results represent an advantage and evidence that chañar is an interesting source for extract polysaccharides with film forming properties.

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Chemical Modification of Polysaccharides and Applications in Strategic Areas

Cited by 6 publications

References 146 publications

Tailor-Made Polysaccharides for Biomedical Applications

Tailor-Made Polysaccharides for Biomedical Applications

Expanding the Repertoire of Electrospinning: New and Emerging Biopolymers, Techniques, and Applications

Synthesis and Characterization of Chanar Gum Films

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