Chemical Modification of Surfaces for Biochemical and Medical Sensor Applications

Ayala, Vanessa; Moosmann, Katrin; Prucker, Oswald; Rühe, Jürgen; Reindl, Leonhard M.

doi:10.1007/978-3-642-03887-7_98

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Biosensors are analytical devices which combine a biologically sensitive element with a physical transducer to selectively and quantitatively detect the trace of biomarkers such as DNA (Auer et al 2011;Lin et al 2010;Nirschl et al 2009), proteins (Kanno et al 2000;Nirschl et al 2009;Quan et al 2011;Quershi et al 2009;Sapsford and Ligler 2004;Zhao et al 2012a), and cells (Ayala et al 2009). There are different technologies that have been used for biosensors, such as electrochemical impedance spectrometry (EIS) (Ge et al 2014;Zhu et al 2014), surface plasmon resonance (SPR) (Cao et al 2006;Liedberg et al 1983), micro-cantilever (MCL) Lee et al 2007) and acoustic wave (Flewitt et al 2015;Guo et al 2015;Katardjiev and Yantchev 2012;Nirschl et al 2010;Voiculescu and Nordin 2012).…”

Section: Introductionmentioning

confidence: 99%

Film bulk acoustic resonators (FBARs) as biosensors: A review

Zhang

Luo

Flewitt

et al. 2018

Biosensors and Bioelectronics

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Biosensors play important roles in different applications such as medical diagnostics, environmental monitoring, food safety, and the study of biomolecular interactions. Highly sensitive, label-free and disposable biosensors are particularly desired for many clinical applications. In the past decade, film bulk acoustic resonators (FBARs) have been developed as biosensors because of their high resonant frequency and small base mass (hence greater sensitivity), lower cost, label-free capability and small size. This paper reviews the piezoelectric materials used for FBARs, the optimisation of device structures, and their applications as biosensors in a wide range of biological applications such as the detection of antigens, DNAs and small biomolecules. Their integration with microfluidic devices and high-throughput detection are also discussed.

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Section: Introductionmentioning

confidence: 99%

Film bulk acoustic resonators (FBARs) as biosensors: A review

Zhang

Luo

Flewitt

et al. 2018

Biosensors and Bioelectronics

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show abstract

“…A combination of biologically sensitive elements with physical transducers was used in biosensors to detect the trace of biomarkers such as DNA (Auer et al, 2011;Nirschl et al, 2009) proteins (Kanno et al, 2000;Quan et al, 2011;Zhao et al, 2012), and cells (Ayala et al, 2009).…”

Section: Transducer Elementsmentioning

confidence: 99%

Projeto, fabricação e aplicação de biossensores de glicose não enzimáticos.

Omidvar¹

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Diabetes is one of the four main noncommunicable diseases and has become one of the fastestgrowing diseases in the world. It will be the seventh leading cause of death worldwide by 2030.The International Diabetes Federation (IDF) has released a new report that demonstrates the global population with diabetes has reached 537 million, increasing 16% since their previous estimation in 2019.Unfortunately, there is no known cure for this chronic health condition; the only alternative to prevent complications for diabetes patients is constantly monitoring their blood glucose levels.Also, the safe range for blood glucose levels is very narrow (between 80-120 mg/dl). Therefore, the sensing method should be able to detect a slight change in concentration in this range. In order to measure the glucose level, biosensors are very practical. A biosensor is transducer capable of converting a biological response into a measurable signal.A novel, low-cost, sensitive microwave microfluidic glucose detecting biosensor incorporating molecularly imprinted polymer is presented. The sensing device is based on dual stub resonators to characterize water glucose solutions. The tip of one of the stubs is coated with MIP to increase the selectivity of the sensor and hence the sensitivity compared to the uncoated or non-imprinted polymer one. The sensor was fabricated on an FR4 substrate for low-cost purposes.In the presence of the MIP, the sensor load-ed with a glucose solution ranging from 50 mg/dL to 400 mg/dL was observed to experience an absorption frequency shift of 73 MHz when the solutions flow in a microfluidic channel passing sensing area, while the Lower Limit of Detection (LLD) of the sensor was discovered to be 2.4 ng/dL. The experimental results showed a high sensitivity of 1.3 MHz /(mg/dL) in terms of absorption frequency.

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Chemical Modification of Surfaces for Biochemical and Medical Sensor Applications

Cited by 2 publications

References 6 publications

Film bulk acoustic resonators (FBARs) as biosensors: A review

Film bulk acoustic resonators (FBARs) as biosensors: A review

Projeto, fabricação e aplicação de biossensores de glicose não enzimáticos.

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