Chemical modification of water-soluble dextrans

Lindenbaum, G. M.; Mirgorodskaya, O. A.; Moskvichev, B. V.

doi:10.1007/bf00779300

Cited by 2 publications

(1 citation statement)

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“…from studies of dextran‐conjugated uricase . However, although periodate oxidation of dextran may be controlled to some extent, inherent drawbacks associated with this method include instability of the dialdehyde intermediate, product heterogeneity due to the presence of multiple ring‐opening sites, and cross‐linking of the target protein if this contains multiple amino groups …”

Section: Carbohydrate Polymersmentioning

confidence: 99%

Half‐Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

2016

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Peptides and proteins constitute a vast pool of excellent drug candidates. Evolution has equipped these molecules with superior drug-like properties such as high specificity and potency. However, native peptides and proteins suffer from an inadequate pharmacokinetic profile, and their outstanding pharmacological potential can only be realized if this issue is addressed during drug development. To overcome this challenge, a variety of half-life extension techniques relying on covalent chemical modification have been developed. These methods include PEGylation, fusion to unstructured polypeptide-based PEG mimetics, conjugation of large polysaccharides, native-like glycosylation, lipidation, fusion to albumin or the Fc domain of IgG, and derivatization with bio-orthogonal moieties that direct self-assembly. This review provides an overview of available conjugation chemistries, biophysical properties, and safety data associated with these concepts. Moreover, the effects of these modifications on peptide and protein pharmacokinetics are demonstrated through key examples.

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Section: Carbohydrate Polymersmentioning

confidence: 99%