Chemical Nature of Metals and Metal-Based Materials in Inactivation of Viruses

Tian, Haozhong; He, Bin; Yin, Yongguang; Shi, Jianbo; Hu, Ligang; Jiang, Guibin

doi:10.3390/nano12142345

Cited by 7 publications

(9 citation statements)

References 193 publications

(297 reference statements)

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“…Metal nanoparticles as photocatalysts have attracted a lot of research interest recently. Among those metal-based materials, copper nanoparticles (Cu NPs) are considered to be a promising photocatalyst and have been proved to have a good bactericidal effect because their narrow band gap can realize visible light absorption. , Kumar et al applied a shellac/CuNPs hybrid nanocoating to surgical masks, thus enhancing the surface hydrophobicity of the masks. Meanwhile, the developed coating surface exhibited superior photocatalytic antimicrobial activity, endowing the mask with reusable and self-disinfecting capabilities (Figure A) …”

Section: Classification Of Photocatalytic Antimicrobialsmentioning

confidence: 99%

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Ran,

Wang

et al. 2023

Chem. Rev.

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Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires the search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on the photoresponsive materials have become a new trend in the inactivation of pathogenic microorganisms due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective and promising antimicrobial strategy in recent years. In the process of photocatalytic treatment, photocatalytic materials are excited by different wavelengths of lights to produce reactive oxygen species (ROS) or other toxic species for the killing of various pathogenic microbes, such as bacteria, viruses, fungi, parasites, and algae. Therefore, this review timely summarizes the latest progress in the PCAT field, with emphasis on the development of various photocatalytic antimicrobials (PCAMs), the underlying antimicrobial mechanisms, the design strategies, and the multiple practical antimicrobial applications in local infections therapy, personal protective equipment, water purification, antimicrobial coatings, wound dressings, food safety, antibacterial textiles, and air purification. Meanwhile, we also present the challenges and perspectives of widespread practical implementation of PCAT as antimicrobial therapeutics. We hope that as a result of this review, PCAT will flourish and become an effective weapon against pathogenic microorganisms and antibiotic resistance.

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Section: Classification Of Photocatalytic Antimicrobialsmentioning

confidence: 99%

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Ran,

Wang

et al. 2023

Chem. Rev.

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“…Metals such as copper and zinc possess several properties including redox, photocatalytic, and structural stability, along with antibacterial and antiviral properties [142], that suggest that their use as antiviral agents in virus-contaminated swine feeds is worth exploring. Copper ions, alone or in copper complexes, have potent antibacterial and antiviral activity [143].…”

Section: Copper and Zincmentioning

confidence: 99%

“…Wei et al [145] compared the antiviral effects of zinc chloride and zinc sulfate when applied to swine testicle cells infected with TGEV and showed that although these zinc salts had no effect on TGEV-cell binding, antiviral effects were observed through the inhibition of virus penetration or exit or the intracellular phase of the TGEV life cycle. Although the chemical structures of metals such as copper and zinc affect their ability to inactivate viruses, their redox capability appears to be a key chemical component affecting antiviral activity [142]. Furthermore, the use of copper and zinc nanoparticles may not only provide direct antiviral activity but may also provide therapeutic effects on animals infected with viruses [142].…”

Section: Copper and Zincmentioning

confidence: 99%

“…Although the chemical structures of metals such as copper and zinc affect their ability to inactivate viruses, their redox capability appears to be a key chemical component affecting antiviral activity [142]. Furthermore, the use of copper and zinc nanoparticles may not only provide direct antiviral activity but may also provide therapeutic effects on animals infected with viruses [142]. Nanoparticles of zinc provide the advantage of greater growth-promoting, antibacterial, and immune responses at lower doses compared with conventional sources [148].…”

Section: Copper and Zincmentioning

confidence: 99%

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Biosecurity and Mitigation Strategies to Control Swine Viruses in Feed Ingredients and Complete Feeds

Shurson

Urriola

Schroeder

2023

Animals

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No system nor standardized analytical procedures at commercial laboratories exist to facilitate and accurately measure potential viable virus contamination in feed ingredients and complete feeds globally. As a result, there is high uncertainty of the extent of swine virus contamination in global feed supply chains. Many knowledge gaps need to be addressed to improve our ability to prevent virus contamination and transmission in swine feed. This review summarizes the current state of knowledge involving: (1) the need for biosecurity protocols to identify production, processing, storage, and transportation conditions that may cause virus contamination of feed ingredients and complete feed; (2) challenges of measuring virus inactivation; (3) virus survival in feed ingredients during transportation and storage; (4) minimum infectious doses; (5) differences between using a food safety objective versus a performance objective as potential approaches for risk assessment in swine feed; (6) swine virus inactivation from thermal and irradiation processes, and chemical mitigants in feed ingredients and complete feed; (7) efficacy of virus decontamination strategies in feed mills; (8) benefits of functional ingredients, nutrients, and commercial feed additives in pig diets during a viral health challenge; and (9) considerations for improved risk assessment models of virus contamination in feed supply chains.

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“…Using self-disinfecting face masks , or surfaces is a convenient and effective approach to control the spread of infections while reducing exposure to disinfectant products, which may cause health problems . Currently available self-disinfecting methods ,− rely on external factors such as heat or light or may not offer rapid disinfection, making them inconvenient or impractical for on-demand use. Hence, achieving rapid and effective antipathogenic performance is essential when developing self-disinfecting coatings.…”

Section: Introductionmentioning

confidence: 99%

Utilizing Rapid Hydrogen Peroxide Generation from 6-Hydroxycatechol to Design Moisture-Activated, Self-Disinfecting Coating

Razaviamri,

Singh,

Manuel

et al. 2024

ACS Appl. Mater. Interfaces

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A coating that can be activated by moisture found in respiratory droplets could be a convenient and effective way to control the spread of airborne pathogens and reduce fomite transmission. Here, the ability of a novel 6-hydroxycatechol-containing polymer to function as a self-disinfecting coating on the surface of polypropylene (PP) fabric was explored. Catechol is the main adhesive molecule found in mussel adhesive proteins. Molecular oxygen found in an aqueous solution can oxidize catechol and generate a known disinfectant, hydrogen peroxide (H2O2), as a byproduct. However, given the limited amount of moisture found in respiratory droplets, there is a need to enhance the rate of catechol autoxidation to generate antipathogenic levels of H2O2. 6-Hydroxycatechol contains an electron donating hydroxyl group on the 6-position of the benzene ring, which makes catechol more susceptible to autoxidation. 6-Hydroxycatechol-coated PP generated over 3000 μM of H2O2 within 1 h when hydrated with a small amount of aqueous solution (100 μL of PBS). The generated H2O2 was three orders of magnitude higher when compared to the amount generated by unmodified catechol. 6-Hydroxycatechol-containing coating demonstrated a more effective antimicrobial effect against both Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria when compared to unmodified catechol. Similarly, the self-disinfecting coating reduced the infectivity of both bovine viral diarrhea virus and human coronavirus 229E by as much as a 2.5 log reduction value (a 99.7% reduction in viral load). Coatings containing unmodified catechol did not generate sufficient H2O2 to demonstrate significant virucidal effects. 6-Hydroxycatechol-containing coating can potentially function as a self-disinfecting coating that can be activated by the moisture present in respiratory droplets to generate H2O2 for disinfecting a broad range of pathogens.

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Chemical Nature of Metals and Metal-Based Materials in Inactivation of Viruses

Cited by 7 publications

References 193 publications

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Biosecurity and Mitigation Strategies to Control Swine Viruses in Feed Ingredients and Complete Feeds

Utilizing Rapid Hydrogen Peroxide Generation from 6-Hydroxycatechol to Design Moisture-Activated, Self-Disinfecting Coating

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