Chemical Pollutants and the Mechanisms of Reactive Oxygen Species Generation in Aquatic Organisms

Regoli, Francesco

doi:10.1002/9781444345988.ch22

Cited by 10 publications

(13 citation statements)

References 51 publications

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“…Firstly, the GQ and BJ populations showed remarkable expression of superoxide dismutase (SOD), which is the first line of defense against reactive oxygen species resulted from metal over-load [49]. The second approach was probably by improving energy production for metal sequestration/detoxification, as indicated by the significant increases of enolase and malate dehydrogenase precursor in the BJ oysters [50,51].…”

Section: Protein Identification In the Oystersmentioning

confidence: 99%

Proteome pattern in oysters as a diagnostic tool for metal pollution

Liu

Wang

2012

Journal of Hazardous Materials

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Section: Protein Identification In the Oystersmentioning

confidence: 99%

Proteome pattern in oysters as a diagnostic tool for metal pollution

Liu

Wang

2012

Journal of Hazardous Materials

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“…Kidney Cd accumulation was associated with an induction of the liver g6pdh gene and a corresponding increase in G6PDH enzyme activity, in the spring. This enzyme is involved in the pentose phosphate pathway and has recently been used as an oxidative stress-related biomarker in a study evaluating the impacts of environmental stressors on fish (Regoli, 2011). It regulates…”

Section: Livermentioning

confidence: 99%

“…the glutathione response to chemical exposure through its involvement in NADPH biosynthesis, which in turn serves as a reducing equivalent in the activity of glutathione reductase (Regoli, 2011). The catalytic response typically follows the transcriptomic response (Nikinmaa and Rytkönen, 2011).…”

Section: Livermentioning

confidence: 99%

Temporal variations in kidney metal concentrations and their implications for retinoid metabolism and oxidative stress response in wild yellow perch (Perca flavescens)

et al. 2018

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The objective of this study was to determine if temporal variations in tissue metal concentrations are related to biomarkers of retinoid metabolism and oxidative stress responses in juvenile yellow perch (Perca flavescens). To this end, kidney metal (Cd, Cu and Zn) concentrations were measured in fish sampled in spring and fall 2012 in four lakes representing a wide range of water and sediment metal contamination in the Rouyn-Noranda (Quebec) region. Lakes Opasatica and Hélène were considered as reference lakes while lakes Dufault and Marlon were metal-contaminated. Kidney concentrations of Cd, Cu and Zn varied widely between spring and fall in fish from both clean and metal-contaminated lakes. An inter-lake difference in renal metal concentrations was only observed for Cd, with fish from Lake Marlon consistently displaying higher concentrations. In the spring, the concentrations of liver dehydroretinol, dehydroretinyl palmitate and total vitamin A esters were higher in fish sampled in the most contaminated lake. Strong temporal variations in the concentrations of these metabolites, as well as in the percentage of liver free dehydroretinol and the epidermal retinol dehydrogenase 2 transcription levels, were observed in fish living in the most metal-impacted lake, with generally higher values in the spring. In contrast to liver, in muscle, no clear seasonal variations in the concentrations of dehydroretinol, dehydroretinyl stearate or in the percentage of free dehydroretinol were observed in fish captured in the most contaminated lake. Temporal variations of traditional biomarkers of oxidative stress response were also observed in the most metal-impacted lake. For example, the transcription level of the gene encoding Cu/Zn superoxide dismutase-1 in liver and muscle catalase activity of perch sampled in the most contaminated lake were higher in spring than in fall. Positive relationships were found between kidney Cd concentrations and the transcription level of the gene encoding glucose 6-phosphate dehydrogenase, and all forms of retinoid concentrations in liver in spring, except with the percentage of free dehydroretinol where the correlation was negative. Our results translate to a state of stress caused by Cd and illustrate that temporal variations in tissue metal concentrations affect retinoid metabolism and antioxidant capacities in juvenile wild yellow perch. Overall this study contributes to highlight the importance of considering temporal variations when investigating the consequences of metal contamination on the physiology of wild fish.

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“…The antioxidant system (AOS) main tains stationary levels of reactive oxygen metabolites (Zenkov et al, 2001;Regoli, 2012). Resistance of the organism to external factors, as well as the ability to adapt to their effects, is largely determined by this sys tem and primarily by the activity of antioxidant enzymes (Ilyukha, 2001).…”

Section: Introductionmentioning

confidence: 99%

Responses of hepatic biochemical markers in bream Abramis brama L. to dietary administered polychlorinated biphenyls

Morozov

Yurchenko

2016

Contemp. Probl. Ecol.

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An experimental study of the effects of dietary administered polychlorinated biphenyls (PCBs) on bream (Abramis brama L.) is reported in the present article. Responses of xenobiotic biotransformation sys tem (ethoxyresorufin O deethylase and glutathione S transferase activities), antioxidant system (superox ide dismutase and catalase activities), and lipid peroxidation system (levels of conjugated dienes and malonic dialdehyde) are investigated. A PCB dose of 2 mg/kg feed does not cause irreversible physiological transfor mations in bream after 14 days of administration. The defense systems appear to efficiently suppress the effects of the xenobiotic and maintain stable and low intensity of the destructive processes at the exposure conditions used.

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Chemical Pollutants and the Mechanisms of Reactive Oxygen Species Generation in Aquatic Organisms

Cited by 10 publications

References 51 publications

Proteome pattern in oysters as a diagnostic tool for metal pollution

Proteome pattern in oysters as a diagnostic tool for metal pollution

Temporal variations in kidney metal concentrations and their implications for retinoid metabolism and oxidative stress response in wild yellow perch (Perca flavescens)

Responses of hepatic biochemical markers in bream Abramis brama L. to dietary administered polychlorinated biphenyls

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