Chemical Porphyria in Japanese Quail

Biomarker Assessment of the Effects of Petroleum Refinery Contamination on Channel Catfish

“…In addition, a stimu-fish from ST-7 sediment cages. The significant increase in levels of Hb were correlated with the increased ALAD activ-lation of ALAD activity was observed in this study, similar to the stimulation of ALAD reported by Stirk (1973) in ity, similar to reports by DeMatteis and Lim (1994). sampling in this pond.…”

Cytological and Biochemical Effects of a Mixture of 20 Pollutants on Isolated Rainbow Trout (Oncorhynchus mykiss) Hepatocytes

“…structures (Strik and Koeman, 1979). In vitro studies with DDT revealed di!erent ultrastructural e!ects in HeLa, human amnion, canine venereal tumor, canine kidney, and rat nephroma cells including chromatin marginalization and condensation in nuclei, irregularities in arrangement of mitochondrial cristae, lipid accumulation, and the presence of multivesicular bodies and autophagic vacuoles (Williams and Chung, 1987).…”

Uroporphyria development in cultured chick embryo fibroblasts long‐term treated with chloramphenicol and ethidium bromide

“…That mitochondria can be involved in the development of uroporphyria is a possibility that has been evoked by other investigators [2,3,17]. However, no direct correlation has yet been established between the impairment of mitochondrial functions and the generally accepted idea that uroporphyria induced in mammals and birds by xenobiotics is caused by decreased activity of uroporphyrinogen decarboxylase.…”

“…Among the xenobiotics tested, polyhalogenated aromatic hydrocarbons (PHA) are known to cause a massive production of uroand heptacarboxyporphyrins in the liver of treated animals (review [2]). This type of porphyria is a time-dependent process which usually takes at least a week in birds [3]. It resembles a syndrome known in man as porphyria cutanea tarda, characterized by a massive accumulation of uroporphyrin in the liver and a marked uroporphyrinuria [4,5].…”