Chemical profile and antifungal activity of plant extracts on Colletotrichum spp. isolated from fruits of Pimenta dioica (L.) Merr.

Silva, Aidé Velázquez; Yerena, Leticia Robles; Necha, Laura Leticia Barrera

doi:10.1016/j.pestbp.2021.104949

Cited by 12 publications

(4 citation statements)

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“…[22] The most abundant terpenes are eucalyptol (36) 43 %, myrcene (37) 35 %, isoeugenol (38) 8 % and α-ocimene (39) 4 %. [48] The oil generally consists of mono/sesqui-terpenes and phenylpropanoids: eugenol (24), methyl eugenol (40), myrcene (37) and 1,8-cineole (36). [4] More specifically the leaf oil of Cuban P. dioica consists majorly of eugenol ( 24), a phenyl propanoid, reaching up to 79.2 %, lesser amounts of mono-terpene are also present including 1,8-cineole (36) (1.1-4.6 %) and the sesquiterpeneoids β-caryophyllene (41) (1-8.7 %), αhumulene (42) (1.0-3.9 %) and caryophyllene oxide (43) (0.2-1.8 %).…”

Section: Essential Oilsmentioning

confidence: 99%

“…The leaves extract is very rich in compounds, it contains flavonoids, tannins triterpenes and galloyl glycosides [22] . The most abundant terpenes are eucalyptol ( 36 ) 43 %, myrcene ( 37 ) 35 %, isoeugenol ( 38 ) 8 % and α ‐ocimene ( 39 ) 4 % [48] . The oil generally consists of mono/sesqui‐terpenes and phenylpropanoids: eugenol ( 24 ), methyl eugenol ( 40 ), myrcene ( 37 ) and 1,8‐cineole ( 36 ) [4] .…”

Section: Phytochemistrymentioning

confidence: 99%

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Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

El‐Nashar,

Ali,

Salem

2023

Chemistry & Biodiversity

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Pimenta is a genus of flowering plants belonging to family Myrtaceae, native to the West Indies, Mexico, and South America. Numerous traditional uses were reported as anti‐inflammatory, analgesic, antipyretic, antirheumatic, antigout, sedative diuretic, sexual stimulant, arthritis and fatigue. This article aims to clarify the reported data about the genus Pimenta, providing a comprehensive overview of its botany, traditional uses, phytochemical profile, pharmacological activities for future exploration of plant‐based drugs and therapeutic approaches. The data were collected from several databases such as Web of Science, Pubmed and Proquest using the terms: "Pimenta", "Pimenta/ phytochemistry", and "Pimenta extracts/ biological activity".The phytochemicals of Pimenta species include tannins, saponins, flavonoids, phenylpropanoids, monoterpenes, sesquiterpenes and essential oils. Several Pharmacological biological activities have been reported for different species such as antihypertensive, antioxidant, antimicrobial, antiviral, histidine decarboxylase inhibition, hypoglycemic, anticancer, anti‐inflammatory, analgesic, antipyretic, acaricidal, anxiolytic, anti‐depressant and anti‐estrogenic. Several scientific reports have been published on various isolated phytochemicals and pharmacological properties of Pimenta species that confirm its ethnobotanical and traditional history. However, in vivo studies on different extracts and their phytoconstituents, alongside mechanistic analysis deserve more attention in future research to provide better guidance to utilize Pimenta as medicinal resources.

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Section: Essential Oilsmentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

El‐Nashar,

Ali,

Salem

2023

Chemistry & Biodiversity

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“…En este sentido, a pesar de que no se han encontrado reportes sobre la inhibición de hongos fitopatógenos con extractos de muérdago, existen datos sobre la actividad antifúngica de diferentes tipos de extractos vegetales para inhibir fitopatógenos, como los reportados por Velázquez et al (2021) que utilizaron extractos etanólicos de Pimenta dioica para inhibir al 100% diferentes cepas de Colletotrichum. Al respecto, Guerra et al (2020) reportaron una ICM de 54.9% de Fusarium oxysporum aplicando extractos de Stevia rebaudiana.…”

Section: Actividad Antifúngica In Vitrounclassified

Inhibición in vitro de hongos fitopatógenos utilizando extractos de muérdago mexicano (Psittacanthus calyculatus)

Xoca-Orozco

Cortez-Fonseca

Luna-López

et al. 2022

Ecosist. Recur. Agropec.

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Psittacanthus calyculatus es una planta hemiparásita que afecta diversas especies vegetales de gran importancia para el ecosistema. Existen diversos reportes sobre su capacidad antibacteriana debido a que contiene diversos compuestos con actividad antioxidante y antimicrobiana, sin embargo, sobre su actividad antifúngica es prácticamente nula la información disponible. Por lo que el objetivo del presente trabajo fue conocer la actividad antifúngica de extractos de muérdago ante la inhibición de Colletotrichum. gloeosporioides, Fusarium sp. y Curvularia sp. Para ello, se utilizó hoja y flor de muérdago obtenidos de dos hospederos: Prosopis laevigata y Eysenhardtia polystachya. Las muestras se lavaron, deshidrataron y molieron. Posteriormente se realizó una extracción sólido-líquido utilizando el metanol-acetona-agua. Se cuantificó el contenido de fenoles y flavonoides, además el perfil fitoquímico cualitativo. La evaluación de la actividad antifúngica se llevó a cabo con la técnica de dilución en placa con medio PDA. Se determinaron los parámetros de inhibición del crecimiento micelial, esporulación, germinación y se determinó el efecto fungicida o fungistático. Los resultados muestran inhibición mayor al 70% con extractos de hoja y flor, siendo Curvularia sp. el más susceptible con un 98% de inhibición. También hubo reducción de la esporulación y germinación de los fitopatógenos evaluados. Se determinó que la inhibición corresponde a un efecto fungistático. Los resultados revelan alta capacidadde inhibición in vitro de extractos de muérdago contra fitopatógenos de gran importancia para la agricultura.

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“…Moreover, Feruloylcholine (having a curcumin moiety) is also reported for its antimicrobial activity against Gram-positive (S. aureus and B. subtilis) and Gram-negative (S. Typhi and K. pneumoniae) [53]. Additionally, Silva et al recently reported the antifungal activity of Tetramethylquercetin [54]. These shortlisted seven compounds were subjected to molecular docking through MOE for detailed study, and it showed binding energies ranging from ~−5 to −7 Kcal/mol.…”

Section: Docking Of Shortlisted Natural Compoundsmentioning

confidence: 99%

Identification of a Novel Therapeutic Target against XDR Salmonella Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening

et al. 2021

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Typhoid fever is caused by a pathogenic, rod-shaped, flagellated, and Gram-negative bacterium known as Salmonella Typhi. It features a polysaccharide capsule that acts as a virulence factor and deceives the host immune system by protecting phagocytosis. Typhoid fever remains a major health concern in low and middle-income countries, with an estimated death rate of ~200,000 per annum. However, the situation is exacerbated by the emergence of the extensively drug-resistant (XDR) strain designated as H58 of S. Typhi. The emergence of the XDR strain is alarming, and it poses serious threats to public health due to the failure of the current therapeutic regimen. A relatively newer computational method called subtractive genomics analyses has been widely applied to discover novel and new drug targets against pathogens, particularly drug-resistant ones. The method involves the gradual reduction of the complete proteome of the pathogen, leading to few potential and novel drug targets. Thus, in the current study, a subtractive genomics approach was applied against the Salmonella XDR strain to identify potential drug targets. The current study predicted four prioritized proteins (i.e., Colanic acid biosynthesis acetyltransferase wcaB, Shikimate dehydrogenase aroE, multidrug efflux RND transporter permease subunit MdtC, and pantothenate synthetase panC) as potential drug targets. Though few of the prioritized proteins are treated in the literature as the established drug targets against other pathogenic bacteria, these drug targets are identified here for the first time against S. Typhi (i.e., S. Typhi XDR). The current study aimed at drawing attention to new drug targets against S. Typhi that remain largely unexplored. One of the prioritized drug targets, i.e., Colanic acid biosynthesis acetyltransferase, was predicted as a unique, new drug target against S. Typhi XDR. Therefore, the Colanic acid was further explored using structure-based techniques. Additionally, ~1000 natural compounds were docked with Colanic acid biosynthesis acetyltransferase, resulting in the prediction of seven compounds as potential lead candidates against the S. Typhi XDR strain. The ADMET properties and binding energies via the docking program of these seven compounds characterized them as novel drug candidates. They may potentially be used for the development of future drugs in the treatment of Typhoid fever.

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Chemical profile and antifungal activity of plant extracts on Colletotrichum spp. isolated from fruits of Pimenta dioica (L.) Merr.

Cited by 12 publications

References 38 publications

Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

Genus Pimenta: An Updated Comprehensive Review on Botany, Distribution, Ethnopharmacology, Phytochemistry and Biological Approaches

Inhibición in vitro de hongos fitopatógenos utilizando extractos de muérdago mexicano (Psittacanthus calyculatus)

Identification of a Novel Therapeutic Target against XDR Salmonella Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening

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