Chemical Profile and Antioxidant Capacity of Propolis from Tetragonula, Lepidotrigona, Lisotrigona and Homotrigona Stingless Bee Species in Vietnam

Popova, Milena; Trusheva, Boryana; Chimshirova, Ralitsa; Antonová, Daniela; Gechovska, Kamelia; Le, Thanh Nguyen; Liên, Nguyễn Thị Kim; Phuong, Diep Thi Lan; Bankova, Vassya

doi:10.3390/molecules27227834

Cited by 8 publications

(7 citation statements)

References 52 publications

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“…These 2 plants were commonly found as resin sources for stingless bee propolis in Vietnam and in other countries. 6,7,9,10,19,33…”

Section: Resultsmentioning

confidence: 99%

“…These 2 plants were commonly found as resin sources for stingless bee propolis in Vietnam and in other countries. 6,7,9,10,19,33 The finding of jatrogossol A (10) indicates Jatropha sp. (Euphorbiaceae) 28 could be one of the plant sources.…”

Section: Compound Identification and Plant Sourcesmentioning

confidence: 99%

“…The ethanol (EtOH) extract of T. iridipennis propolis showed antioxidant, antimicrobial, and anticancer activities. [15][16][17][18][19] We have analyzed the chemical composition of several T. iridipennis propolis samples by gas chromatography/mass spectrometry to reveal the presence of sugars, sugar alcohols, fatty acids, aromatic acids, phenolic lipids, and triterpenes. 19 Further chemical and biological studies are needed to explore the chemical constituents and plant sources for propolis and to identify bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis

Phuong,

Cong,

Phuong

et al. 2023

Natural Product Communications

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Objective: Propolis of Tetragonula iridipennis, which is one of the most popular stingless bees found in Vietnam, has been used to promote health and prevent disease. This study aims to identify the chemical constituents of T iridipennis propolis and their cytotoxic activity. Methods: The propolis sample was extracted with ethanol. The crude extract was isolated by combined chromatographic methods. The structures of isolated compounds were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. The cytotoxicity was evaluated by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide method. The protein interactions of active compounds were explored by molecular docking study. Results: Sixteen known compounds, including 11 triterpenes, 3 xanthones, a sterol, and a flavonoid were isolated and identified. The propolis ethanol extract displayed good cytotoxicity against A-549 and KB cancer cell lines. 24 S,25-Dihydroxytirucall-7-en-3-one was the most active compound with IC50 values ranging from 18.75 ± 0.21 to 19.62 ± 0.36 µg/mL. Conclusions: Sixteen known constituents were identified from T. iridipennis propolis, of which 8 compounds were discovered for the first time. The propolis of T iridipennis has multiple sources of plant resin, among that Ailanthus triphysa (Simaroubaceae) was identified as a new plant source. A molecular docking study revealed that cytotoxic effects of 24 S,25-dihydroxytirucall-7-en-3-one, α-mangostin, 6-methoxy–bispyrano xanthone, and 3-isomangostin related to the inhibition of all 3 targets epidermal growth factor receptor, human epidermal growth factor receptor 2, and mammalian target of rapamycin (mTOR), while other isolated triterpenes exert their cytotoxicity by the inhibition of mTOR protein activity.

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“…These 2 plants were commonly found as resin sources for stingless bee propolis in Vietnam and in other countries. 6,7,9,10,19,33…”

Section: Resultsmentioning

confidence: 99%

Section: Compound Identification and Plant Sourcesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis

Phuong,

Cong,

Phuong

et al. 2023

Natural Product Communications

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“…In the realm of organic constituents, noteworthy elements include terpenes and steroids, as well as sugars and amino acids, along with various flavonoids. Notable among the flavonoids are caffeic, cinnamic, p-coumaric, and chicoric acids, as well as quercetin, pinocembrin, baicalin, galangin, and chrysin, owing to their significant antiglycation [ 37 , 38 , 39 ], cardioprotective [ 40 , 41 , 42 , 43 , 44 ], neuroprotective [ 45 , 46 , 47 , 48 , 49 , 50 ], cytostatic [ 51 , 52 , 53 ], radioprotective [ 54 , 55 , 56 , 57 ], antimicrobial [ 58 , 59 , 60 , 61 , 62 , 63 ], anticancer [ 64 , 65 , 66 , 67 , 68 , 69 , 70 ], antioxidant [ 71 , 72 , 73 , 74 , 75 , 76 ], immunomodulatory [ 77 , 78 , 79 , 80 , 81 , 82 , 83 ], antidiabetic [ 84 , 85 , 86 , 87 , 88 , ...…”

Section: Propolismentioning

confidence: 99%

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Scorza,

Goncalves,

Finsterer

et al. 2024

Cells

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Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis’ properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis’ role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.

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“…These bees produce propolis, which has high economic value (Priawandiputra et al 2020). Its propolis contains antioxidant and antibacterial compounds potentially used for medical treatment (Sanpa et al 2015;Popova et al 2022). This bee has a stingless morphological structure that makes it easy and widely cultivated by beekeepers in Indonesia (Buchori et al 2022).…”

Section: H a Y At I H A Y At Imentioning

confidence: 99%

The Toxicity Test of Synthetic Insecticides on Tetragonula laeviceps (Apidae: Meliponini)

Hasanah,

Mubin,

Sartiami

et al. 2023

HAYATI J Biosci

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Intense insecticide application is thought to cause a decline in bee colonies worldwide. Bees are effective pollinators in increasing the production of agricultural commodities. The stingless bee Tetragonula laeviceps (Apidae: Meliponini) is widely cultivated and found around plantations. The insecticides used in the toxicity test were imidacloprid 200 g/L, fipronil 50 g/L, lambda-cyhalothrin 25 g/L, profenofos 500 g/L, and chlorantraniliprole 50 g/L followed by a semi-field test using imidacloprid, fipronil, and profenofos insecticides on the cucumber plant. The LC50 value showed that exposure to imidacloprid, fipronil, and profenofos insecticides caused toxic effects on T. laeviceps by contact and orally. Lambda-cyhalothrin was found harmful on contact exposure, in contrast, chlorantraniliprole was harmful through oral. Classification of insecticide toxicity based on LD50 contact for imidacloprid, fipronil, lambda-cyhalothrin, and profenofos were very toxic and needed a risk assessment. However, chlorantraniliprole was classified as moderately toxic and low risk. In semi-field test results, imidacloprid and fipronil insecticides caused a significant decrease in the leave-return and bee-visiting activity on cucumber flowers. These insecticides also produced a low average yield of fruit weight. Insecticide application can affect the role of T. laeviceps as the pollinator which impacts the production of agricultural commodities.

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Chemical Profile and Antioxidant Capacity of Propolis from Tetragonula, Lepidotrigona, Lisotrigona and Homotrigona Stingless Bee Species in Vietnam

Cited by 8 publications

References 52 publications

Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis

Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

The Toxicity Test of Synthetic Insecticides on Tetragonula laeviceps (Apidae: Meliponini)

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