Chemical profile and bioactive properties of the essential oil isolated from Clinopodium serpyllifolium (M.Bieb.) Kuntze growing in Palestine

Ali‐Shtayeh, Mohammed S.; Jamous, Rana M.; Abu-Zaitoun, Salam Y.; Akkawi, Rola J.; Kalbouneh, Samer R.; Bernstein, Nirit; Dudai, Nativ

doi:10.1016/j.indcrop.2018.08.038

Cited by 19 publications

(14 citation statements)

References 40 publications

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“…Determination of EO composition was performed using gas chromatography-mass spectrometry (GC-MS) following the conditions reported in [16, 27]. The identification of the constituents was based on comparison of their relative retention indices and spectra with spectra of NIST 98, QuadLib1607 GC-MS, and Adams libraries [34].…”

Section: Methodsmentioning

confidence: 99%

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Biological Properties and Bioactive Components ofMentha spicataL. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer’s Disease, Dermatophytosis, and Drug-Resistant Infections

Ali‐Shtayeh¹,

Jamous²,

Abu-Zaitoun³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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In the present study, the medicinal aromatic plant Mentha spicata has been investigated as a source of essential oil (EO) and pharmaceuticals. The quantity and composition of EO from M. spicata cultivated in Palestine were analyzed seasonally over a three-year period. A significantly higher EO content was produced in summer and fall months (2.54–2.79%). Chemical analysis of EO revealed 31 compounds with oxygenated monoterpenes (90%) as the most abundant components followed by sesquiterpene and monoterpene hydrocarbons (6 and 3%, respectively). M spicata can be characterized as a carvone chemotype (65%). EO and carvone have shown strong inhibitory activities against the principal enzymes associated with Alzheimer's disease (AD) and overweight diseases (cholinesterase and porcine pancreatic lipase) and also shown strong antidermatophytic activity against Microsporum canis, Trichophyton rubrum, T. mentagrophytes, and Epidermophyton floccosum. The pancreatic lipase inhibition and the synergism showed the potential activity of M. spicata EO and carvone and that their combinations with standard drugs can be useful for the treatment of obesity and overweight. The results also demonstrated that, in addition to their significant inhibitory activity against biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA), M. spicata EO and carvone had a strong inhibitory effect on metabolic activity and biomass of the preformed biofilm. The current study supports the utilization of M. spicata EO as a traditional medicine and opens perceptions to find more potent substances in the EO for the management of obesity, AD, and dermatophytosis and for combating drug-resistant bacterial infections.

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Section: Methodsmentioning

confidence: 99%

“…The effects of seasons on the biochemical features of some EOs of the Lamiaceae family have been described in the literature [16, 27]. However, no information is available on how seasonal variations would affect the EO content, composition, and yields of the major oil constituents of spearmint cultivated in Palestine.…”

Section: Introductionmentioning

confidence: 99%

Biological Properties and Bioactive Components ofMentha spicataL. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer’s Disease, Dermatophytosis, and Drug-Resistant Infections

Ali‐Shtayeh¹,

Jamous²,

Abu-Zaitoun³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…BERC-BX603) has been deposited at BERC Herbarium, Til, Nablus, Palestine. 250 gm of the fresh aboveground plant parts were subjected to hydrodistillation using a modified Clevenger apparatus until there was no significant increase in the amount of EO collected [18].…”

Section: Plant Materials and Essential Oil Extractionmentioning

confidence: 99%

“…Oil. Gas chromatographymass spectrometry (GC-MS) was performed to determine the EO composition by using the conditions reported by Ali-Shtayeh et al [18]. Identification of the compounds was performed by comparing their relative retention indices (RI) with those of authentic compounds (e.g., carvacrol, terpinolene, ε-caryophyllene, and β-bisabolene) or by comparing their mass spectral fragmentation patterns with Wiley 7 MS library (Wiley, New York, NY, USA) and NIST98 (Gaithersburg, MD, USA) mass spectral database.…”

Section: Gc-ms Analysis Of Essentialmentioning

confidence: 99%

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Ali‐Shtayeh¹,

Abu-Zaitoun²,

Dudai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Lavandula pubescens Decne (LP) is one of the three Lavandula species growing wildly in the Dead Sea Valley, Palestine. The products derived from the plant, including the essential oil (EO), have been used in Traditional Arabic Palestinian Herbal Medicine (TAPHM) for centuries as therapeutic agents. The EO is traditionally believed to have sedative, anti-inflammatory, antiseptic, antidepressive, antiamnesia, and antiobesity properties. This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16–0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.08 μL/mL) effects. The EO also demonstrated high antibacterial activity with the highest susceptibility observed for Staphylococcus aureus with 95.7% inhibition. The EO was shown to exhibit strong inhibitory activity against Candida albicans (MIC 0.47 μL/mL). The EO was also shown to possess strong antidermatophyte activity against Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum (EC50 0.05–0.06 μL/mL). The high antioxidant, enzyme inhibitory, and antimicrobial potentials of the EO can, therefore, be correlated with its high content of monoterpenes, especially carvacrol, as shown by its comparable bioactivities indicators results. This study provided new insights into the composition and bioactivities of LP EO. Our finding revealed evidence that LP EO makes a valuable natural source of bioactive molecules showing substantial potential as antioxidant, neuroprotective, antihyperlipidemic, and antimicrobial agents. This study demonstrates, for the first time, that LP EO might be useful for further investigation aiming at integrative CAM and clinical applications in the management of dermatophytosis, Alzheimer’s disease, and obesity.

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“…Medicinal aromatic plants are cultivated to obtain specialty products including oils and pharmaceuticals (Ali-Shtayeh et al 2018). Nigella sativa, annual herbaceous plant, is generally known as black caraway seed and black cumin which belongs to Ranunculaceae family (Forouzanfar et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Çörek Otu Tohumu Yağının Kimyasal İçeriği ve Biyolojik Aktivite Spektrumu

Sıcak

Eliuz

2019

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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In this study, it was aimed to investigate the chemical composition and biological activities including antioxidant, anticholinesterase, antimicrobial and urease activity of Nigella sativa seed oil growing in Muğla (Köyceğiz). The oil of plant was obtained using Soxhlet apparatus. Thirty-one components of the oil were determined by Gas Chromatography-Mass Spectrometry (GC-MS). The major components of oil were detected as palmitic acid (10.48%), linoleic acid (8.05%), o-cyemene (7.11%), 3,5-dimethyl cyclohexanol (6.68%), thymoquinone (6.44%), p-tert-buthyl catechol (6.28%) and 8-methyl-1undecene (3.28%). The findings obtained from biological activity assays showed that Nigella sativa oil was a promising candidate that can be used in the discovery of new drugs and the preparation of new natural drug preparations.

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Chemical profile and bioactive properties of the essential oil isolated from Clinopodium serpyllifolium (M.Bieb.) Kuntze growing in Palestine

Cited by 19 publications

References 40 publications

Biological Properties and Bioactive Components ofMentha spicataL. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer’s Disease, Dermatophytosis, and Drug-Resistant Infections

Biological Properties and Bioactive Components ofMentha spicataL. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer’s Disease, Dermatophytosis, and Drug-Resistant Infections

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Çörek Otu Tohumu Yağının Kimyasal İçeriği ve Biyolojik Aktivite Spektrumu

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