Chemical profile and biological properties of the endemic Turkish species Phyllocara aucheri

Varvouni, Elisavet-Foteini; Zengin, Gökhan; Graikou, Konstantia; Ganos, Christos; Mroczek, Tomasz; Chinou, İoanna

doi:10.1016/j.sajb.2020.11.003

Cited by 3 publications

(7 citation statements)

References 22 publications

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“…All phenolic metabolites have been identified recently from natural plant samples of Rindera graeca [ 8 ]. Most of the caffeic acid derivatives have been identified in multiple Boraginaceae species, while rosmarinic acid is a well-known chemotaxonomic marker of the family [ 7 , 8 , 9 ]. Rabdosiin, a dimer of rosmarinic acid, and its disodium salt, a nontrivial compound recently isolated from Alkanna sfikasiana [ 5 ] and detected in natural plant of R. graeca [ 8 ], has previously been studied for potential cytotoxic and antiviral activities [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…Rosmarinic acid, a metabolite with rich biological activity, is commonly found in plants of the Boraginaceae family, serving as a chemotaxonomic marker [ 7 , 8 , 9 ]. The metabolites quercetin-3-rutinoside-7-rhamnoside and rabdosiin disodium salt, previously identified from the natural plant, were also isolated.…”

Section: Resultsmentioning

confidence: 99%

“…In the framework of the studies of our scientific team on Mediterranean endemic Boraginaceae species [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ], the genus Rindera Pall. belonging to tribe Cynoglosseae of the borage plant family has attracted our scientific interest [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature, several biotechnological approaches have been used to enhance the production of phenolic compounds in in vitro cultures of plant organs, tissues, and cells [ 11 ], especially towards rosmarinic acid (RA) production, which is a well-known chemotaxonomic marker among Boraginaceae plants [ 7 , 8 , 9 ]. RA, as an ester of caffeic acid, is often followed by its derivatives, lithospermic acid (LA) and rabdosiin [ 5 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Profile and Screening of Bioactive Metabolites of Rindera graeca (A. DC.) Bois. & Heldr. (Boraginaceae) In Vitro Cultures

Graikou

Damianakos

Ganos

et al. 2021

Plants

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Rindera graeca is a rare endemic plant where in vitro culture has been used in order to investigate bioactive metabolites. Phytochemical study of the in vitro shoots and hairy roots led to the isolation of seven phenolic derivatives and the unusual furano-naphthoquinone rinderol. R. graeca was also analyzed for its pyrrolizidine alkaloids content by LC-MS, and it was found to contain echinatine together with echinatine and rinderine N-oxides. Rinderol, isolated only from in vitro hairy root culture for the first time in the genus, revealed promising bioactivities. It was evaluated in vitro against a panel of microorganisms, showing very strong activity specifically against Gram-positive bacteria (MIC values 0.98 × 10−2–1.18 µg/mL) as well as very interesting antiproliferative effect against the human non-small-cell bronchopulmonary carcinoma cell line NSCLC-N6-L16 and the epidermoid lung cancer cell line A549. These findings were compared with the chemical profile of the plant from nature, while this study is the first to report on the effects of R. graeca extracts obtained from in vitro culture, providing a valuable contribution to the scientific community towards this sustainable method of production of potential bioactive molecules.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Profile and Screening of Bioactive Metabolites of Rindera graeca (A. DC.) Bois. & Heldr. (Boraginaceae) In Vitro Cultures

Graikou

Damianakos

Ganos

et al. 2021

Plants

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“…In the framework of our research on Boraginaceae plants [ 3 , 4 , 11 , 12 , 13 ], we herein present the phytochemical study on the aerial parts of H. procumbens from Panama in order to evaluate its chemical composition, the total phenolic and flavonoid content, antioxidant activity, inhibitory potentials against key clinical enzymes involved in neurodegenerative diseases (cholinesterases AChE, BChE), in skin whitening (tyrosinase), and in diabetes (α-amylase, α-glucosidase).…”

Section: Introductionmentioning

confidence: 99%

Heliotropium procubens Mill: Taxonomic Significance and Characterization of Phenolic Compounds via UHPLC–HRMS- In Vitro Antioxidant and Enzyme Inhibitory Activities

et al. 2023

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The aim of the present study was the phytochemical analysis of the aerial parts of Heliotropium procumbens Mill., a herb from Boraginaceae plant family not previously studied. The methanol (ME) and aqueous extracts (WE) of the aerial parts were assayed for their total phenolic and flavonoid content and antioxidant properties, using free radical scavenging (DPPH, ABTS), reducing power (FRAP, CUPRAC), phosphomolybdenum and metal chelating assays. The extracts displayed considerable free radical scavenging activity against DPPH and ABTS radicals, with potential values of 46.88 and 68.31 mg TE/g extract for ME, and 93.43 and 131.48 mg TE/g extract for WE, respectively. Key clinical enzymes involved in neurodegenerative diseases AChE and BChE, diabetes (α-amylase and α-glucosidase) and skin whitening (tyrosinase) were also assayed. The phytochemical profile of the studied species was determined through UHPLC–HRMS, whereby 26 secondary metabolites were identified, three of which (luteolin-7-glucoside, lithospermic and rosmarinic acids) were isolated and structurally determined by NMR spectral means. H. procubens was found to harbor bioactive metabolites and could, hence, serve as a source of biological activities which could be further explored and exploited for potential applications.

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Anchusa Azurea var. Kurdica Köklerinin Farklı Özütlerinin Yaygın Kronik Hastalıkların Tedavisinde Kullanım Potansiyellerinin Belirlenmesi

Abdulqadir,

Şen,

Zengin

et al. 2024

Aksaray University Journal of Science and Engineering

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Günümüzde yaygın olarak görülen bazı kronik hastalıkların hala bilinen bir tedavisi yoktur. Bu nedenle bu hastalıkların tedavisi için yöntem ve ilaç geliştirme çalışmaları devam etmektedir. Sentetik ilaçlar tedavide başarılı bir şekilde kullanılsa bile, bazı yan etkileri nedeniyle bu ilaç geliştirme çalışmalarında doğal ürünlerin tercih edilmesi giderek yaygınlaşmaktadır. Bu çalışma Anchusa azurea var. kurdica köklerinin antioksidan ve enzim inhibisyon aktivitelerinin belirlenerek bitkinin diyabet, Alzheimer ve kanser gibi hastalıkların tedavisinde kullanılabilme potansiyelinin ortaya konulmasına odaklanmıştır. Burada kök kısımlarından farklı çözücüler ile elde edilen özütlerinin antioksidan aktiviteleri serbest radikal giderme aktivitesi (DPPH, ABTS), FRAP, CUPRAC, fosfomolibdat ve metal şelatlama aktivite testleri ile belirlenmiştir. Enzim inhibisyon aktiviteleri kolinesteraz (asetil ve bütiril), α-amilaz, α-glukozidaz ve tirozinaz enzimleri için araştırılmıştır. Ayrıca özütlerin toplam fenolik ve flavonoid içerikleri yanında fenolik bileşimleri de belirlenmiştir. Antioksidan aktivite testlerinde genel olarak metanol özütü diğerlerine kıyasla yüksek aktivite gösterirken, enzim inhibisyonunda etil asetat özütü daha aktif bulunmuştur. Metanol ekstraktındaki toplam fenolik içerik 22,12 mg GAE/g ekstrakt olarak bulunurken, flavonoid içeriği tüm ekstraktlarda oldukça düşük seviyelerde bulunmuştur. Özütlerin fenolik bileşimlerinde kuersetin ve rosmarinik asit yüksek oranda bulunan fenolik bileşenler olmuştur. Elde edilen verilere göre A. azurea var. kurdica kök özütleri iyi düzeyde antioksidan ve enzim inhibisyon aktivitesi göstermiştir. Sonuçlar bitkinin kronik hastalıklarının tedavisine yönelik ilaç geliştirme çalışmalarında hammadde olarak kullanım potansiyelinin yüksek olduğunu göstermiştir.

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Chemical profile and biological properties of the endemic Turkish species Phyllocara aucheri

Cited by 3 publications

References 22 publications

Chemical Profile and Screening of Bioactive Metabolites of Rindera graeca (A. DC.) Bois. & Heldr. (Boraginaceae) In Vitro Cultures

Chemical Profile and Screening of Bioactive Metabolites of Rindera graeca (A. DC.) Bois. & Heldr. (Boraginaceae) In Vitro Cultures

Heliotropium procubens Mill: Taxonomic Significance and Characterization of Phenolic Compounds via UHPLC–HRMS- In Vitro Antioxidant and Enzyme Inhibitory Activities

Anchusa Azurea var. Kurdica Köklerinin Farklı Özütlerinin Yaygın Kronik Hastalıkların Tedavisinde Kullanım Potansiyellerinin Belirlenmesi

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