Chemical Profile and Cytotoxic Activity of Leaf Extracts from<i>Senna</i>spp. from Northeast of Brazil

Silva, Juliana G. A.; Silva, Alexander A.; Coutinho, Isabel D.; Pessoa, Cláudia; Cavalheiro, Alberto José; Silva, Maria Goretti de Vasconcelos

doi:10.5935/0103-5053.20160073

Cited by 11 publications

(13 citation statements)

References 24 publications

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“…After, was added MSTFA (200 μL), and water bath at 37 °C for 30 min. 23 The extracts were then filtered and stored for 24 h at 4 °C prior to chromatographic analysis.…”

Section: Extraction and Derivatizationmentioning

confidence: 99%

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Guedes¹,

Filho²,

Silva³

et al. 2020

J. Braz. Chem. Soc.

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Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds.

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“…After, was added MSTFA (200 μL), and water bath at 37 °C for 30 min. 23 The extracts were then filtered and stored for 24 h at 4 °C prior to chromatographic analysis.…”

Section: Extraction and Derivatizationmentioning

confidence: 99%

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Guedes¹,

Filho²,

Silva³

et al. 2020

J. Braz. Chem. Soc.

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“…The phytochemical investigations on Astragalus creticus lead to the isolation of a tannin, one fatty acid, one terpene, four flavonoids and two sterols. The purified compounds were reported previously from various plants like Ethyl gallate from Acacia leucophloea and Rhynchosia phaseoloides (Calderon et al 2006;Leela and Saraswathy 2013), 1-Triacontanoic acid from Desmodium sambuense and Senna trachypus (Li et al 2010;Silva et al 2016), Kaemferol-7-O--Dglucopyranoside from Cassia renigera and Securigera securidaca (Behbahani et al 2014;Singh et al 2011) of family Fabaceae. The rest of the compounds were already Antimicrobial resistance is increasing day by day (Mayers et al 2017).…”

Section: Discussionmentioning

confidence: 91%

Untitled

2021

Pak. J. Pharm. Sci

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This study was carried out to isolate the secondary metabolites and to evaluate the antibacterial, antifungal, antioxidant, phytotoxic, anti-leishmanial and α-glucosidase activities of dichloromethane and methanol extracts of whole plant of Astragalus creticus. Preliminary phytochemical screening indicated flavonoids, saponins, tannins and cardiac glycosides in this plant. Phytochemical evaluation of methanol extract resulted in isolation and characterization of Ethyl gallate, 1-triacontanoic acid, quercimeritrin, kaempferol-7-O-β-D-glucopyranose, myricetin, kaempferol, betulinic acid, stigmasterol and Daucosterol. The structures of the compounds were determined by Mass and NMR spectroscopy. The methanol extract exhibited better activity against Staphylococcus aureus (58.75%) while dichloromethane extract was found to be very active against Bacillus subtilis (56.30%).The methanol extract demonstrated highly significant phytotoxic (92.68% at 1000µg/ml) and antioxidant (64.55±0.43%) potential while both extracts identified best inhibition of α-glucosidase enzyme. The plant extracts showed non-significant antifungal and anti-leishmanial activities. To our knowledge, it's a first research study on Astragalus creticus that indicate a great biological and phytochemical potential in it.

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“…A previous study has identified neophytadiene in cytotoxic fractions of Senna spp. (Leguminosae, Caesalpinioideae) tested against human colon and human glioblastoma cell lines [34]. Interestingly, the increase of neophytadiene concentration in fraction DA-FH (15.3 %) compared to DA-FF (3.9 %) led to higher cytotoxic effects in Vero cells.…”

Section: Resultsmentioning

confidence: 99%

GC-MS Analysis, Bioactivity-based Molecular Networking and Antiparasitic Potential of the Antarctic Alga Desmarestia antarctica

Santos

Rangel

Teixeira

et al. 2020

Planta Medica International Open

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Leishmaniasis, malaria, and neosporosis are parasitic diseases that affect humans and animals, causing public health problems and billions in economic losses. Despite the advances in the development of new drugs, the severe side effects of available leishmaniasis treatments, the Plasmodium spp. resistance to antimalarial drugs, and the lack of a specific treatment against neosporosis lead us to the search for new anti-protozoan molecules from underexplored sources such as the Antarctic marine environment. Herein, we describe for the first time the chemical profile of Desmarestia antarctica crude extract and fractions using GC-MS and LC-MS/MS (molecular networking) approaches, and evaluate their antiparasitic activity against Leishmania amazonensis, Neospora caninum, and multi-drug-resistant Plasmodium falciparum. Furthermore, the cytotoxicity in 3T3 BALB/c fibroblasts and Vero cells was evaluated. D. antarctica fraction E ( IC50 of 53.8±4.4 μg mL− 1 and selectivity index of 3.3) exhibited anti-promastigote activity and was fourfold more selective to L. amazonensis rather than to the host cells. D. antarctica fraction D (IC50 of 1.6±1.3 μg mL− 1 and selectivity index of 27.8), D. antarctica fraction F (IC50 of 3.1±2.1 μg mL− 1 and selectivity index of 23.1), and D. antarctica fraction H (IC50 of 3.1±2.0 μg mL− 1 and selectivity index of 12.9) presented the highest antiparasitic effects against N. caninum with no cytotoxic effects. Also, D. antarctica fraction D presented a significant antiplasmodial inhibitory effect (IC50 of 19.1±3.9 μg mL− 1 and selectivity index of 6.0). GC-MS analysis indicated palmitic acid, myristic acid, fucosterol, phthalic acid, di(2-methylbutyl) ester, loliolide, and neophytadiene as the main components in the active fractions. In addition, this is the first report of a biological screening of macroalgae secondary metabolites against N. caninum parasites.

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Chemical Profile and Cytotoxic Activity of Leaf Extracts fromSennaspp. from Northeast of Brazil

Cited by 11 publications

References 24 publications

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Untitled

GC-MS Analysis, Bioactivity-based Molecular Networking and Antiparasitic Potential of the Antarctic Alga Desmarestia antarctica

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