Chemical profile and pancreatic lipase inhibitory activity of <i>Sinobambusa tootsik</i> (Sieb.) Makino leaves

Qiu, Xiaolin

doi:10.7717/peerj.7765

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…This finding was in consonance with other findings that proved the aqueous ethanol and n-butanol fraction of M. stenopetala leaves had notable antihyperglycemic and dyslipidemic activity [ 4 ]. Reduced cholesterogenesis and fatty acid production by inhibition of pancreatic cholesterol esterase and pancreatic lipase, respectively, may possibly explain the reported antihyperlipidemic effect [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Andargie

Sisay

Molla

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Conventional antidiabetic drugs are linked with a number of contraindications and untoward effects. The root decoction of Solanum incanum L. has traditionally been used to treat diabetes. However, its safety and efficacy have not been scientifically authenticated yet. Hence, the study was conducted in mice to corroborate its antidiabetic potential and safety profile. Methods. Using normoglycemic, oral glucose-loaded, and streptozotocin-induced diabetic mice models, the hypoglycemic and antihyperglycemic activities of 80% methanolic root extract were investigated. On streptozotocin-induced diabetic mice, the effect of the test extract on diabetic lipid profile and body weight was also investigated. Further, the in vitro α-amylase inhibition activity was assessed. Results. The test extract was safe at a limit test dose of 2 g/kg. Dose-dependent α-amylase inhibition activity was seen with peak percentage inhibition of 75.95% at 700 μg/mL. In normoglycemic mice, the plant extract showed statistically significant hypoglycemic activity at 200 and 400 mg/kg ( P < 0.001 ) at 6 h and 4 and 6 h of treatment, respectively; in oral glucose-loaded mice, at both the test doses, the glucose level was also significantly dropped at 120 ( P < 0.01 ) and 60 and 120 min ( P < 0.001 ), respectively; whereas, in the third model, the test extract showed significant antihyperglycemic activity at 100 mg/kg ( P < 0.05 ) on the 14th day and at 200 ( P < 0.01 ) and 400 mg/kg ( P < 0.001 ) on the 7th and 14th day of treatment. Similarly, following repeated administration of the test extract at 200 and 400 mg/kg, the body weight was significantly improved on the 14th day ( P < 0.05 ) and on the 7th and 14th day ( P < 0.01 ), respectively, while diabetic dyslipidemia after 14 days ( P < 0.05 ). Conclusion. The study revealed that the test extract showed promising antihyperglycemic and antihyperlipidemic activity. Thus, the findings back up its use in Ethiopian remedies for diabetes.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Andargie

Sisay

Molla

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Pancreatic lipase inhibitory activities of secoiridoids were determined as previously reported [ 68 , 69 ]. Briefly, the enzyme solution was prepared by the reconstitution of porcine pancreatic lipase (Sigma-Aldrich, St. Louis, MO, USA) in 0.1 M Tris-HCl buffer (pH = 8).…”

Section: Methodsmentioning

confidence: 99%

Anti-Obesity and Gut Microbiota Modulation Effect of Secoiridoid-Enriched Extract from Fraxinus mandshurica Seeds on High-Fat Diet-Fed Mice

Guo

Zhao

et al. 2020

Molecules

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Previously we conducted a phytochemical study on the seeds of Fraxinus excelsior and isolated nine secoiridoid compounds with adipocyte differentiation inhibitory activity and peroxisome proliferator activated receptor alpha (PPARα) activation effects. However, the bioactive constituents and functions of Fraxinus mandshurica seeds have not been studied. In the present study, we investigated the secoiridoid compounds in F. mandshurica seed extract (FM) using column chromatography, 1H-NMR, 13C-NMR and HPLC-DAD methods. The pancreatic lipase inhibitory activities of isolated compounds were evaluated in vitro. Additionally, the anti-obesity and gut microbiota modulation effect of FM on high-fat diet-induced obesity in C57BL/6 mice were also studied in vivo. The results showed that 19 secoiridoids were isolated from FM and identified. The total content of secoiridoids in FM reached 181.35 mg/g and the highest content was nuzhenide (88.21 mg/g). All these secoiridoid compounds exhibited good pancreatic lipase inhibitory activity with inhibition rate ranged from 33.77% to 70.25% at the concentration of 100 μM. After obese mice were administrated with FM at 400 mg/kg.bw for 8 weeks, body weight was decreased by 15.81%. Moreover, FM could attenuate the lipid accumulation in serum and liver, relieve the damage in liver and kidney, and extenuate oxidative stress injury and inflammation caused by obesity in mice. FM could also modulate the structural alteration of gut microbiota in obese mice, increasing the proportion of anti-obesity gut microbiota (Bacteroidetes, Bacteroidia, S24-7 and Allobaculum), and reducing the proportion of obesogenic gut microbiota (Firmicutes and Dorea). This study suggests that F. mandshurica seeds or their secoiridoids may have potential for use as a dietary supplement for obesity management.

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“…The inhibition of C/EBP alpha, PPAR-gamma, and SREBP may be effective for obesity treatment [ 97 ]. The phytochemicals such as apigenin [ 98 ], guggul sterols [ 99 ], naringenin, genistein [ 100 ], hesperidin, myricetin, kaempferol, and rutin [ 101 ] have been proven effective in downregulating the differentiation of adipocytes ( Table 2 ). This inhibition of adipocyte differentiation by apigenin is linked with possible inhibition of interleukin 6, leptin production, and monocyte chemoattractant protein 1 (MCP-1).…”

Section: Obesity Regulating Mechanisms Of Natural Phytochemicalsmentioning

confidence: 99%

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

Kumar

Singh

Lakhawat

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.

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Chemical profile and pancreatic lipase inhibitory activity of Sinobambusa tootsik (Sieb.) Makino leaves

Cited by 9 publications

References 24 publications

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Anti-Obesity and Gut Microbiota Modulation Effect of Secoiridoid-Enriched Extract from Fraxinus mandshurica Seeds on High-Fat Diet-Fed Mice

Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches

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