Chemical Profile, Antioxidative, and Gut Microbiota Modulatory Properties of Ganpu Tea: A Derivative of Pu-erh Tea

Zheng, Yonghua; Zeng, Xuan; Chen, Tingting; Peng, Wei; Su, Weiwei

doi:10.3390/nu12010224

Cited by 39 publications

(30 citation statements)

References 47 publications

(54 reference statements)

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“…Catechins are the predominant active compounds of tea and can inhibit catechol‐O‐methyltransferase, an enzyme to degrade noradrenalin (Samavat et al, 2016), and promotes the expression of peroxisome proliferator activated receptor/phosphatidylinositol 3‐kinase pathway to reduce insulin resistance and free fatty acid level by activating the expression of protein kinase A in its downstream. Another mechanism of cardiovascular protection is to modulate T cell differentiation and altered gut microbiota (Pei, Liu, & Bolling, 2020; Zheng, Zeng, Chen, Peng, & Su, 2020). Besides, Yamagata and colleagues illustrated that epigallocatechin gallate (EGCG) found in green tea acts as an antioxidant, inducing nitric oxide release and preventing the production of reactive oxygen species (ROS) to inhibit inflammation (Yamagata, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Liu

Wan

Huang

et al. 2020

Phytotherapy Research

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The metabolic syndrome (MetS) is one of the major health hazards and an epidemic worldwide. There is no known best remedy has been defined yet. In the current investigation, we designed a meta-analysis of randomized clinical trials (RCTs) to evaluate the beneficial effects of tea consumption in alleviating metabolic syndromes. Herein, we accumulated the relevant literature available on PubMed and EMBASE databases from January, 2000 to August, 2019. RCTs bearing impact factor of at least 1 or more were studied for the effect of tea consumption on MetS. This metaanalysis suggested that tea consumption has beneficial effects on diastolic blood pressure (DBP), and this finding was characterized of all types of tea in the current study and also for body mass index (BMI) value. Furthermore, this analysis also found that black tea consumption has protective effects on systolic SBP, green tea reduces the incidence of diabetes and lower the level of low-density lipoprotein (LDL) cholesterol. These functions required BMI value at least 28 or higher. The meta data led us to conclude that tea consumption have protective effects on MetS, however, different types of tea might have different protective mechanisms on MetS, but, exact mechanisms are not yet clear and needs to be explored.

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Section: Discussionmentioning

confidence: 99%

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Liu

Wan

Huang

et al. 2020

Phytotherapy Research

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“…Total bacterial DNA were extracted and amplified as previously described (Zheng et al, 2020). After PCR amplification, sequencing was performed on an Illumina Hiseq 2500 platform by Biomarker Technologies Co. Ltd. (Beijing, China).…”

Section: Gut Microbiota Analysis Using 16s Rrna Gene Sequencingmentioning

confidence: 99%

Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium Against Reserpine-Induced Spleen Deficiency in Rats

et al. 2020

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Citri Reticulatae Pericarpium (CRP), dried peels of Citrus reticulata Blanco and its cultivars, is an important traditional Chinese medicine for the treatment of spleen deficiency-related diseases. To date, the mechanism of CRP alleviating spleen deficiency has not been well investigated. This study aimed to explore corresponding mechanisms with integrating pharmacology and gut microbiota analysis. Firstly, the therapeutic effects of CRP against spleen deficiency were evaluated in reserpine-treated rats. CRP was found to effectively relieve the typical symptoms of spleen deficiency, including poor digestion and absorption capacity, and disorder in gastrointestinal hormones, immune cytokines and oxidative stress. Secondly, high throughput 16S rRNA gene sequencing revealed that CRP could not only up-regulate some short-chain fatty acids producing and anti-inflammatory bacteria but also down-regulate certain spleen deficiency aggravated related bacteria, eventually led to the rebalance of gut microbiota in spleen deficiency rats. In addition, a total of 49 compounds derived from CRP were identified in rat urine using ultra-high performance liquid chromatography-quadrupole-time of flight tandem mass spectrometry. Network pharmacology analysis showed that apigenin, luteolin, naringenin, hesperidin, hesperetin, homoeriodictyol, dihydroxytetramethoxyflavone, and monohydroxy-tetramethoxyflavone were the core bioactive components for CRP against spleen deficiency. Further Gene Ontology analysis and pathway enrichment suggested that therapeutic effects of CRP against spleen deficiency involved multiple pathways such as tumor necrosis factor signaling, hypoxia-inducible factor-1 signaling and Toll-like receptor signaling pathway. These results would help to understand the mechanism of CRP alleviating spleen deficiency and provide a reference for further studies.

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“…This increase was associated with diets rich in polyphenols. Byproducts of bacterial metabolism play a vital role in maintaining and maintaining colon metabolism (Zheng et al, 2020).…”

Section: Chemical Compounds Responsible For the Bioactive Profilementioning

confidence: 99%

Pu-erh tea: Fermentative process as a potentialized of sensory aspects and bioactive profile – a review

Devos

Barth

Dettmer

et al. 2021

RSD

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Pu-erh is a fermented Chinese tea with characteristics of mild, woody flavor and dark red color. The preparation of the tea starts from leaves of Camellia sinensis in natura that undergo a drying in the sun. Its classification is given in two categories: a raw tea similar to green tea and a matured tea that is fermented. Matured tea has a higher market value due to the processes involved in manufacturing, especially in terms of aging. Pu-erh has numerous benefits for human health, which are closely related to the bioactive profile of the main chemical components of tea, being polyphenols, theabrownins, flavonols, polysaccharides, amino acids and alkaloids. The increasing introduction of Pu-erh tea in the diet of consumers results in the need to explore information associated with consumption through analysis of the available literature, addressing current scientific evidence. Therefore, the present review sought to elucidate the fermentative process of Pu-erh tea production, its chemical composition, its sensory aspects and health benefits.

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Chemical Profile, Antioxidative, and Gut Microbiota Modulatory Properties of Ganpu Tea: A Derivative of Pu-erh Tea

Cited by 39 publications

References 47 publications

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium Against Reserpine-Induced Spleen Deficiency in Rats

Pu-erh tea: Fermentative process as a potentialized of sensory aspects and bioactive profile – a review

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