Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

Shang, Zhuo; Li, Xiaoming; Li, Meng; Li, Chun‐Shun; Gao, Shiqiang; Huang, Chun; Wang, Bin‐Gui

doi:10.1007/s00343-012-1075-1

Cited by 59 publications

(50 citation statements)

References 26 publications

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“…Xanthocillin X resulted in the most promising secondary metabolites extracted from this fungus for displaying an antiproliferative activity against liver, prostate, and breast cancer cell lines. Similar effects were observed with meleagrin on the prostate cancer cell line [155,156]. In addition, Aspergillus dimorphicus SD317, isolated from deep-sea sediments of South China Sea, whose genus identified in DHABs (i.e., L'Atalante, Thetis and Urania), produced anti-tumour agent Wentilactone A and B [157].…”

Section: Fungi In Dhabs As Potential Producers Of Biomolecules For Phsupporting

confidence: 59%

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

et al. 2019

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Deep-sea hypersaline anoxic basins (DHABs) are one of the most hostile environments on Earth. Even though DHABs have hypersaline conditions, anoxia and high hydrostatic pressure, they host incredible microbial biodiversity. Among eukaryotes inhabiting these systems, recent studies demonstrated that fungi are a quantitatively relevant component. Here, fungi can benefit from the accumulation of large amounts of organic material. Marine fungi are also known to produce bioactive molecules. In particular, halophilic and halotolerant fungi are a reservoir of enzymes and secondary metabolites with valuable applications in industrial, pharmaceutical, and environmental biotechnology. Here we report that among the fungal taxa identified from the Mediterranean and Red Sea DHABs, halotolerant halophilic species belonging to the genera Aspergillus and Penicillium can be used or screened for enzymes and bioactive molecules. Fungi living in DHABs can extend our knowledge about the limits of life, and the discovery of new species and molecules from these environments can have high biotechnological potential.

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Section: Fungi In Dhabs As Potential Producers Of Biomolecules For Phsupporting

confidence: 59%

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

et al. 2019

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“…This finding may facilitate further studies to gain a better understanding of broad‐spectrum antibacterial metabolite production in this fungus. It is also important that inoculation time of bacterial competitors had affected production and activity of fungal metabolites . Nevertheless and interestingly, the role of co‐cultivation in promoting the broad‐spectrum antibacterial activity was also supported by another fungus A. carneus (SF114B) in the present study (Table ).…”

Section: Resultssupporting

confidence: 67%

“…Two fungal genera, Penicillium and Aspergillus , are known to produce a large variety of compounds with a wide range of biological and pharmacological activities . It is well known that P. atrovenetum , P. commune , and P. restrictum have been reported as producers of anticancerogenic and antimicrobial compounds with considerable inhibition to Gram‐positive and ‐negative bacteria . Similarly, the results suggested the strong antimicrobial activity of many marine fungi (11 isolates).…”

Section: Resultsmentioning

confidence: 97%

Marine Fungi Against Aquaculture Pathogens and Induction of the Activity via Co‐Culture

Özkaya

Peker

Camas

et al. 2017

CLEAN Soil Air Water

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Ethyl acetate extracts from 70 strains of marine-derived fungi, isolated from sponges, were screened against four fish pathogenic bacteria. Sixteen of the fungal isolates exhibited antibacterial activity against at least one pathogen. All the strains showed antibacterial activity against Vagococcus salmoninarum. Three isolates showed strong inhibition against all test pathogens and they may therefore be remarkable as a broadspectrum antimicrobial. Nine isolates showed antibacterial activity against Lactococcus garvieae, six were against Vibrio anguillarum, and four isolates inhibited the growth of Yersinia ruckeri. Co-culture of the fungus with the mix of the pathogen bacteria led to the induction of bioactivity in two isolates. Aspergillus iizukae produced strong and broadspectrum antibacterial activity against pathogens with minimum inhibitory concentrations of 0.8-406 mg mL À1 . The screening results confirmed the sponge associated fungi as a source of environmentally friendly antimicrobials that may contribute the sustainable development of aquaculture. In addition, co-culture technique is a promising strategy to increase antimicrobial activity that can stimulate the production of novel compounds, and increases the antimicrobial activities of marine derived fungi.

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“…The isolated compounds 1-4 were evaluated for their cytotoxic activity against five selected human cancer cell lines (Table 2) In addition to LAMA-1, the structures of other known compounds 2-4 ( Figure 1) were elucidated by comparing their detailed NMR spectral data with those in the literature. These compounds were identified as ergosterol (2) [28][29][30], epidioxyergosterol (3), [30,31], and kojic acid (4) [32][33][34][35].…”

Section: Cytotoxic Activity Of Isolated Compounds 1-4mentioning

confidence: 99%

“…Here, we report the isolation, structure elucidation, and cytotoxic profiles of the purified compounds, including a cerebroside molecular species (1), together with the known reported compounds ergosterol (2) [28][29][30], epidioxyergosterol (3) [30,31], and kojic acid (4) [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

et al. 2020

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Chemical investigation of the ethyl acetate extract of Penicillium chrysogenum strain S003, a fungus isolated from Red Sea deep sediment, led to the isolation of a cerebroside molecular species LAMA (1) along with three other known compounds, ergosterol (2), epidioxyergosterol (3), and kojic acid (4). The structures of the isolated compounds were elucidated by interpretation of spectral data, including detailed 1D and 2D NMR (One and two dimensional Nuclear Magnetic Resonance) and mass spectrometry. The cytotoxic activities of isolated compounds 1–4 against five human carcinoma cells were evaluated using sulforhodamine B (SRB) assay. Compounds 2 and 3 displayed promising cytotoxic profiles against lung cancer (A-549), prostate (DU-145), breast adenocarcinoma (MCF-7), and hepatocellular (HepG2) cell lines, with IC50 values of 21.26, 19.3; 1.50, 6.10; 16.95, 13.6; and 2.89, 3.07 µM, respectively, while they were inactive against HeLa cells. Compounds 1 and 4 showed weak cytotoxic profiles against all cell lines under investigation.

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Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

Cited by 59 publications

References 26 publications

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

Marine Fungi Against Aquaculture Pathogens and Induction of the Activity via Co‐Culture

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

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