Chemical profiles with cardioprotective and anti-depressive effects of <i>Morus macroura</i> Miq. leaves and stem branches dichloromethane fractions on isoprenaline induced post-MI depression

Hamdan, Dalia I.; Hafez, Samia; Hаssаn, Wаfаа S.; Morsi, Mai; Khalil, Heba M. A.; Ahmed, Yasmine H.; Ahmed-Farid, Omar A.; El-Shiekh, Riham A.

doi:10.1039/d1ra08320a

Cited by 7 publications

(1 citation statement)

References 63 publications

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“…In our in vivo study, MI was induced by S/C injection of ISP at a dose of 85 mg/kg for two consecutive days. Then, the treatment strategies begin after the ISP challenge and continue for 19 days, according to our previous study [41]. MI and depressive-like behavior of the ISP intoxicated group were investigated at the end of the experiment.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats

et al. 2022

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Hypericum perforatum (HP) is characterized by potent medicinal activity. However, the poor water solubility of many HP constituents limits their therapeutic effectiveness. Self-nanoemulsifying self-nanosuspension loaded with HP (HP.SNESNS) was formulated to improve the bioefficacy of HP. It was prepared using 10% triacetin, 57% Tween 20, and 33% PEG 400 and then incorporated with HP extract (100 mg/mL). HP.SNESNS demonstrated a bimodal size distribution (258.65 ± 29.35 and 9.08 ± 0.01 nm) corresponding to nanosuspension and nanoemulsion, respectively, a zeta potential of -8.03 mV, and an enhanced dissolution profile. Compared to the unformulated HP (100 mg/kg), HP.SNESNS significantly improved cardiac functions by decreasing the serum myocardial enzymes, nitric oxide (NO), and tumor necrosis factor- α (TNF-α) as well as restoring the heart tissue's normal architecture. Furthermore, it ameliorates anxiety, depressive-like behavior, and cognitive dysfunction by decreasing brain TNF-α, elevating neurotransmitters (norepinephrine and serotonin), and brain-derived neurotrophic factor (BDNF). In addition, HP.SNESNS augmented the immunohistochemical expression of cortical and hippocampal glial fibrillary acidic protein (GFAP) levels while downregulating the cortical Bcl-2-associated X protein (Bax) expression levels. Surprisingly, these protective activities were comparable to the HP (300 mg/kg). In conclusion, HP.SNESNS (100 mg/kg) exerted antidepressant and cardioprotective activities in the post-MI depression rat model. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%