Chemical profiling and biological activity analysis of cone, bark and needle of Pinus roxburghii collected from Nepal

Thapa, Rupak; Upreti, Anil; Pandey, Bishnu Prasad

doi:10.5455/jice.20171013045424

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GC-MS is a Gas Chromatography-Mass Spectrometry a combined technique to separate and quantify the compounds from any sample for characterization purposes. This present study was carried out by using data from a GC-MS study that was performed by (Satyal et al, 2013;Bhardwaj et al, 2022;Thapa et al, 2018).…”

Section: Selection Of Phytocompoundsmentioning

confidence: 99%

Integrative in silico analysis of Pinus Roxburghii phytochemicals for drug discovery

Prajapati,

Patel

2023

Drug Dicov

View full text Add to dashboard Cite

The aim of the present study is to investigate in silico analysis of Pinus Roxburghii plant's photo component for the disease of non-small-cell lung cancer (NSCLC).We observed that many people have problems like lung cancer, and they were treated with synthetic medicine, which is already made from chemical compounds, and so for this study, we are targeting the plant which is in INDIAN Tropical forests. That plant's bark contains various chemicals that have been used to prevent a disease like lung cancer. In this work, we use various In Silico tools for many testing we use PubChem Database to obtain the details of the chemical components of the plants like chemical structures, properties, and other relevant data for small molecules, etc., with the help of PubChem we download the ligand and protein of the disease. After that, we use I gem Dock for docking the ligand and protein interaction. Then, we use VEGA QSAR for mutagenicity, carcinogenicity, Toxicity, etc. Then, ADMET/ADME tools are used to predict compounds' absorption, distribution, metabolism, excretion, and toxicity. After that, we use the Lipinski rule of five. After performing all these methods, I found that the plant's Bark compound is highly able to interact with the Disease protein it is shown the inhibition is the same as Drugs that are available in the market.

show abstract

Section: Selection Of Phytocompoundsmentioning

confidence: 99%